Prognosis in Colorectal Carcinoma

Brandão, Otília; Sobrinho-Simões, Manuel; Serrão, Daniel; Moutinho-Ribeiro, Manuel; Azevedo, C. A. de

doi:10.1016/s0344-0338(85)80013-3

Cited by 15 publications

(3 citation statements)

References 15 publications

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“…The prognostic significance of the invasion of blood vessels, lymph vessels and peripheral nerves has been previously emphasized [7]. Our results suggest that, with increase in the immunohistochemical grading, there is high ability of tumor to invade surrounding structures.…”

Section: Discussionsupporting

confidence: 63%

See 1 more Smart Citation

Carcinoembryonic Antigen Immunoreactivity Patterns in Colorectal Cancer: Correlation with Morphologic Parameters

Anđelinović¹,

Bakotin²,

Dujić³

et al. 1991

Ann Saudi Med

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Section: Discussionsupporting

confidence: 63%

“…The tumors were, according to their macroscopic appearance, described as exophytic (N = 28), ulcero-exophytic (N = 26) and ulcerated and/or infiltrative (N = 46) [7].…”

Section: Methodsmentioning

confidence: 99%

Carcinoembryonic Antigen Immunoreactivity Patterns in Colorectal Cancer: Correlation with Morphologic Parameters

Anđelinović¹,

Bakotin²,

Dujić³

et al. 1991

Ann Saudi Med

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“…Poorly differentiated adenocarcinomas are thought to behave more aggressively than well or moderately dif ferentiated adenocarcinomas [5]. Moreover, in a previous study, moderately differentiated carcinoma was shown to have a higher malignant potential in comparison with well differentiated carcinoma [6], Supporting this theory, some clinicopathological studies have reported that the survival of colorectal-cancer patients correlates significantly with the histologic differentiation of the tumors [2][3][4]. The his tologic diagnosis of colorectal carcinoma is usually based on the dominant part of the tumor [8], However, the selec tion of the dominant portion does not necessarily result in the selection of the portion reflecting the biological behav ior of the tumor.…”

Section: Discussionmentioning

confidence: 92%

The Clinical Significance of the Histologic Subclassification of Colorectal Carcinoma

Teixeira

Tanaka²,

Haruma³

et al. 1993

Oncology

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According to the histologic features at the deepest level of tumor invasion (the tumor apex), we classified colorectal carcinomas as follows: well differentiated (W), moderately differentiated (M), and mucinous (Muc). By assessing its glandular configuration and cellular arrangement, the M type was further subdivided in to two different groups: moderately well differentiated (Mw) and moderately poorly differentiated (Mp) carcinomas. In our sample there were 56 W, 53 Mw, 20 Mp and 13 Muc tumors. The malignant potential of each tumor was evaluated by examining for the presence or absence of lymphatic invasion, venous invasion, lymph node metastases and liver metastases. In comparison with the other tumors, the Mp tumors proved to harbor the highest malignant potential, exhibiting a higher incidence of lymphatic invasion (95%, 19/20 of the cases), venous invasion (75%, 15/20 of the cases), lymph node metastases (80%, 16/20 of the cases), and liver metastases (40%, 8/20 of the cases). Colorectal carcinomas are composed of multiple cell populations with different biological and malignant properties, and through the histologic sub-classification we could identify that Mp tumors have the highest potential to invade normal tissue and metastasize.

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Carcinomatous lymphatic permeation. Prognostic significance in patients with rectal carcinoma—A long term prospective study

Shirouzu¹,

Isomoto²,

Morodomi³

et al. 1995

Cancer

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Background. The question of whether lymphatic permeation in rectal carcinoma is an index of prognosis remains controversial. Methods. A long term prospective study of lymphatic permeation of 288 rectal carcinomas was performed. The degree of lymphatic permeation was divided into four stages (Ly0 through Ly3). The median follow‐up for the surviving patients was 84 months (range, 23 to 151 months). Results. In patients with UICC Stage I or II disease, there was no correlation between the Ly0 and Ly1‐3 groups' recurrence or survival rates. In patients with Stage IIIa disease, the rate of postoperative recurrence was significantly higher in the Ly1 or Ly2 + Ly3 groups compared with the Ly0 group. The 10‐year survival and disease free survival rates in patients with Stage IIIa disease were both 90.0% in the Ly0 group, 63.6% and 62.5% in the Ly1 group, and 52.0% and 45.5% in the Ly2 + Ly3 groups, respectively. A significant difference was noted in the survival rates between the Ly0 and Ly2 + Ly3 groups (P < 0.05), and was noted in the disease free survival rates between the Ly0 and Ly1 (or Ly2 + Ly3) groups (P < 0.05, P < 0.005). In patients with Stage IIIb disease, there were trends toward higher recurrence, lower survival, or disease free survival rates in the Ly2 + Ly3 groups compared with the Ly1 group (P < 0.1). Conclusions. The degree of lymphatic permeation is an important prognostic factor in patients with Stage III disease, especially in those with Stage IIIa disease. It should be classified as a clinical subgroup.

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Prognosis in Colorectal Carcinoma

Cited by 15 publications

References 15 publications

Carcinoembryonic Antigen Immunoreactivity Patterns in Colorectal Cancer: Correlation with Morphologic Parameters

Carcinoembryonic Antigen Immunoreactivity Patterns in Colorectal Cancer: Correlation with Morphologic Parameters

The Clinical Significance of the Histologic Subclassification of Colorectal Carcinoma

Carcinomatous lymphatic permeation. Prognostic significance in patients with rectal carcinoma—A long term prospective study

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