Prognosis of Breast Cancer Patients Underwent Surgery in a Developing Country

Abstract

Background: We aim to review different factors associated with the relapse and the mortality in breast cancer patients in restricted-resource settings over a five-year period. Method: A retrospective cohort study including 133 women underwent breast cancer surgery was performed at the Surgical Oncology Unit of the Conakry University Hospital in Guinea. Socio-demographical characteristics, clinical information, treatment and data on relapse and survival were retrieved from medical files. Predictor factors of relapse were analyzed by using univariate and multivariate logistic regression. Factors associated with mortality were analyzed by Kaplan Meier survival and Cox models. Results: Breast cancer surgery was conservative in 13 cases (9.8%) and radical in 120 cases (90.2%). Five-year relapse was 33.8% ± 8.0% and the predictor factors of this relapse were age and stage III (p = 0.005). The overall 5-year mortality was 42.1% and the risk factors independently associated with death were body mass index (p = 0.01), origin of patients (p = 0.02), radiotherapy (p = 0.01) and cancer relapse (p = 0.001). Conclusion: The proportions of relapse and death were higher in breast cancer patients. The age and the stage of cancer at the time of surgery were the predictor factors of relapse. Body mass index, origin of patients, radiotherapy and cancer relapse were associated with death.

Molecular profile of breast cancers in Guinean oncological settings

“…This target therapy has been made possible through the use of monoclonal antibodies and hormone therapy. In our country, immunohistochemistry (IHC) is not available and there are very little data on the molecular profile of breast cancer [4, 9]. This study aimed to determine the first trends in the molecular profile of breast cancers followed at the surgical oncology unit of Donka National Hospital.…”

Female breast cancer in sub‐Saharan Africa: A PRISMA‐S‐compliant systematic review of surgery

“…The stage at diagnosis was reported in 7/13 studies 25–27,30,33–36 ; histopathology data were found in all the studies except two, 25,35 and hormonal status in 5 out of 13 studies 26,27,30,33,34 . Data about the CT use were in all the studies except one 29 .…”

“…The group of “FBC surgical excision/reconstruction” studies was composed of 12 publications. The 5‐year overall survival (OS) or mortality rate were described in only one 25 ; two studies reported OS with a follow‐up less than 5 years, 26,27 and one reported the metastasis‐free survival data 26 …”

“…Bilateral therapeutic mammoplasty in most of the patients (222/251) was reported by Grubnick et al (2013); BCS was traced in two studies of South Africa 28 . BCS (or BCT) was reported in studies performed in Guinea, 25 South Africa, 28–32 Zambia, 33 and in an international multicenter study conducted in Ghana, Kenya, and Nigeria 34 …”

“…Neoadjuvant CT (NACT) was traceable in six studies reporting data about CTs 26–28,31,32,33 and in two studies as adjuvant CT 26,27 . Two studies indicated the use of CT generically 25,37 . The use of HT was reported in two 27,34 and the use of RT in six studies 25–27,30,34,36 …”