Prognosis of fetuses with ventriculomegaly: An observational retrospective study

Chang, Qing; Peng, Yanjie; Huang, Quan; Zhong, Ming; Huang, Liping; Li, Jing; Chen, Cuihua

doi:10.1002/pd.5503

Cited by 14 publications

(15 citation statements)

References 26 publications

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“…However, there are many studies on the postnatal follow-up of isolated VM. [31][32][33] In conclusion, this study found that antenatal MRI is beneficial in cases with isolated VM and is especially helpful in cases with moderate VM, anterior placenta, mothers with higher BMI, and in the diagnosis of high-grade intracranial hemorrhage accompanying mild or moderate VM. We recommend performing an antenatal MRI for all fetuses with isolated VM.…”

Section: Discussionmentioning

confidence: 60%

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Contribution of fetal magnetic resonance imaging in the evaluation of neurosonographically detected cases of isolated mild and moderate cerebral ventriculomegaly

Adiyaman¹,

Öztekin

Kuyucu³

et al. 2022

J of Obstet and Gynaecol

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Aim This study aimed to present the contribution of prenatal magnetic resonance imaging (MRI) in the diagnosis of fetuses that were previously identified as isolated mild and moderate cerebral ventriculomegaly (VM) by ultrasound (US). Methods The data between February 2013 and August 2020 were collected for women who were diagnosed with isolated mild or moderate fetal VM by US and subsequently underwent a fetal MRI. Results Among 321 women, 21 (6.5%) had a clinically important additional finding after MRI. Twelve of 276 (4.3%) fetuses with mild VM and 9 of 45 (20%) with moderate VM had turned out to have additional central nervous system abnormalities. Additional findings were detected more in fetuses with moderate VM, mothers with an anterior‐located placenta, and mothers with higher body mass indexes (BMIs) with statistical significance (p = 0.001, p = 0.013, p = 0.036, respectively). The most common additional MRI finding was grade 3 or 4 germinal matrix hemorrhage, which was detected in 11 of 21 fetuses (52.3%). Conclusions Considering the countries' health policies, prenatal MRI would contribute mostly to the diagnosis of fetuses with moderate VM, pregnancies with anterior‐located placenta, and mothers with high BMIs. According to our data, we believe that MRI will be valuable, especially in the diagnosis of grade 3 and 4 intracranial hemorrhage group.

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Section: Discussionmentioning

confidence: 60%

“…Therefore, we were unable to determine the postnatal outcomes of isolated VM. However, there are many studies on the postnatal follow‐up of isolated VM 31–33 …”

Section: Discussionmentioning

confidence: 99%

Contribution of fetal magnetic resonance imaging in the evaluation of neurosonographically detected cases of isolated mild and moderate cerebral ventriculomegaly

Adiyaman¹,

Öztekin

Kuyucu³

et al. 2022

J of Obstet and Gynaecol

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“…Progression of ventriculomegaly was defined as ventricular enlargement greater than 2 mm compared with the initial measurement. Stable ventriculomegaly was defined as an enlargement of less than 2 mm, and regressive ventriculomegaly was defined as a decrease of 2 mm or more or as a ventricular diameter of less than 10 mm [8,13].…”

Section: Ultrasoundmentioning

confidence: 99%

Asymmetric cortical development and prognosis in fetuses with isolated mild fetal ventriculomegaly: an observational prospective study

Zhu

Chen

Hou

et al. 2021

BMC Pregnancy Childbirth

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Background Assessments of cortical development and identifying factors that may result in a poor prognosis for fetuses with isolated mild ventriculomegaly (IMVM) is a hot research topic. We aimed to perform a constant, detailed assessment of cortical development in IMVM fetuses using ultrasound and determine whether asymmetric cortical development occurred. Moreover, we aimed to estimate the prognosis of IMVM fetuses and compare the difference in the prognosis of IMVM fetuses presenting symmetric and asymmetric cortical maturation. Methods IMVM was diagnosed by regular ultrasound, neurosonography and fetal MRI. Genetic and TORCH examinations were conducted to exclude common genetic abnormalities and TORCH infection of fetuses. Ultrasound examinations were conducted at an interval of 2–3 weeks to record sulcus development in IMVM fetuses using a scoring system. The neonatal behavioral neurological assessment (NBNA), the Ages and Stages Questionnaire, Third Edition (ASQ-3) and the Bayley Scales of Infant Development, First Edition (BSID-I) were performed after birth. Results Forty fetuses with IMVM were included: twenty showed asymmetric cortical maturation and twenty showed symmetric cortical maturation. For IMVM fetuses presenting asymmetric cortical maturation, the mean gestational age (GA) at the first diagnosis of relatively delayed development was 24.23 weeks for the parieto-occipital sulcus, 24.71 weeks for the calcarine sulcus, and 26.43 weeks for the cingulate sulcus. All the sulci with delayed development underwent ‘catch-up growth’ and developed to the same grade as the sulci of the other hemisphere. The mean GA at which the two sides developed to the same grade was 29.40 weeks for the parieto-occipital sulcus, 29.30 weeks for the calcarine sulcus and 31.27 weeks for the cingulate sulcus. The NBNA, ASQ-3 and BSID-I scores of all patients were in the normal range. Conclusions IMVM fetuses may show mild asymmetric cortical maturation in the second trimester, but the relatively delayed sulci undergo ‘catch-up growth’. The neurodevelopment of IMVM fetuses presenting asymmetric cortical maturation and ‘catch-up growth’ is not statistically significantly different from IMVM fetuses presenting symmetric cortical maturation.

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“…Progression of ventriculomegaly was de ned as ventricular enlargement of greater than 2 mm compared with the initial measurement. Stable ventriculomegaly was de ned as an enlargement of less than 2 mm, and regressive ventriculomegaly was de ned as a decrease of 2 mm or more or as a ventricular diameter of less than 10 mm 9,14 .…”

Section: Ultrasoundmentioning

confidence: 99%

Cortical Development Assessed by Ultrasound in Fetuses with Isolated Mild Fetal Ventriculomegaly: Asymmetric Cortical Growth, 'catch-up growth' Pattern and Postnatal Neurodevelopment Outcome

Zhu

Chen

Hou

et al. 2020

Preprint

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Background: Assessment of cortical development and identifying factors that may result in a poor prognosis for fetuses with isolated mild ventriculomegaly (IMVM) is a hot research topic. We aimed to perform a constant detailed assessment of cortical development in IMVM fetuses by ultrasound and determine whether asymmetric cortical development occurs in IMVM fetuses. Moreover, we aimed to estimate the prognosis of IMVM fetuses and compare the difference of prognosis of IMVM fetuses with symmetric and asymmetric cortical maturation.Methods: IMVM was diagnosed by regular ultrasound, neurosonography, fetal MRI, and genetic and TORCH examinations. Ultrasound examinations were carried out with an interval of 2-3 weeks to record sulcus development in IMVM fetuses using a scoring system. The neonatal behavioral neurological assessment (NBNA), the Ages and Stages Questionnaire, Third Edition (ASQ-3) and the Bayley Scales of Infant Development (BSID-I) were used after birth.Results: Forty IMVM fetuses were included, twenty showed asymmetric cortical maturation, and twenty showed symmetric cortical maturation. The mean gestational age (GA) at the first diagnosis of relatively delayed development was 24.23weeks for the parieto-occipital sulcus, 24.71weeks for the calcarine sulcus, and 26.43weeks for the cingulate sulcus. The mean GA that two sides developed to the same grade was 29.40weeks for the parieto-occipital sulcus, 29.30weeks for the calcarine sulcus and 31.27weeks for the cingulate sulcus. The NBNA, ASQ-3 and BSID-I scores of all patients were in the normal range.Conclusion: IMVM fetuses may show mild asymmetric cortical maturation in the second trimester, but the relatively delayed sulci would undergo 'catch-up growth'. The neurodevelopment of IMVM fetuses with asymmetric cortical maturation and 'catch-up growth' is not statistically significantly different from that of IMVM fetuses with symmetric cortical maturation.

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Prognosis of fetuses with ventriculomegaly: An observational retrospective study

Cited by 14 publications

References 26 publications

Contribution of fetal magnetic resonance imaging in the evaluation of neurosonographically detected cases of isolated mild and moderate cerebral ventriculomegaly

Contribution of fetal magnetic resonance imaging in the evaluation of neurosonographically detected cases of isolated mild and moderate cerebral ventriculomegaly

Asymmetric cortical development and prognosis in fetuses with isolated mild fetal ventriculomegaly: an observational prospective study

Cortical Development Assessed by Ultrasound in Fetuses with Isolated Mild Fetal Ventriculomegaly: Asymmetric Cortical Growth, 'catch-up growth' Pattern and Postnatal Neurodevelopment Outcome

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