Prognosis of Male Breast Cancer: A Systematic Review of the Literature

Abstract

Authors PB and CRC managed the literature searches, collected the data, performed the statistical analysis, checked the analyses, drafted and revised the manuscript. Authors AB and LCST conceived the idea and its analytic strategy, checked data extraction and analyses, interpreted the findings, drafted and revised the manuscript. All authors read and approved the final manuscript.

Male Breast Cancer: Treatment Trends, Reported Outcomes, and Suggested Recommendations

“…MBC patients, when treated by surgery, had an increase in postoperative survival (surgery hazard ratio (HR)=0.49, p< 0.001) as compared with alternative treatments [ 12 ]. However, every surgical procedure presents its own set of risks and possible acute and chronic complications, which are not well elaborated in the literature on MBC [ 13 ]. Based on available data collected from 2007-16, 4.6% of men reported postsurgical complications within 30 days following any surgical breast cancer management, with 3.2% of those being wound complications (superficial surgical site infection (SSI) 2.4%, deep SSI 0.5%, organ space SSI 0.2%, wound disruption 0.1%) [ 14 ].…”

“…The lack of MBC specific clinical trials [ 17 ], screening guidelines [ 7 ], and trial-based standard of care treatment options [ 18 ], along with limited reports on treatment-associated complications [ 13 ], makes choosing the optimal treatment difficult for patients and treating physicians [ 19 ]. Surveys show that 36% of recently diagnosed men wanted more male-specific breast cancer information on surgical treatment options, sentinel node biopsies, prophylactic mastectomies, and non-surgical treatments [ 19 ].…”