Prognosis of patients with haematological malignancies admitted to the intensive care unit: Sequential Organ Failure Assessment (SOFA) trend is a powerful predictor of mortality

Prognostic factors in critically ill patients with hematologic malignancies admitted to the intensive care unit

“…These results are consistent with previous studies, which suggested that IMV is a strong predictor of mortality in patients with hematologic malignancies [5][6][7]11,12,19]. Other factors thought to be associated with high mortality when admitted to the ICU include old age, the presence of hemodynamic instability, neutropenia, number of failing organs, and the presence of graft-versushost disease after allogeneic HSCT [5,[7][8][9][10][11][12][14][15][16].…”

“…Preferably, these decisions should be based on the prognoses tailored to individual patients. Although several studies have identified prognostic factors aiming to maximize survival and limit unnecessary suffering and costs, few of those studies were published in the last 5 years [5,13,14,16]. Moreover, the survival in mechanically ventilated patients after HSCT has shown an improvement with advances in the treatment and outcome of patients admitted to the ICU [17].…”

“…Unfortunately, more intense cancer treatment has led to increasing numbers of therapyassociated complications, which may be life threatening and often necessitate transfer to an intensive care unit (ICU). Although favorable ICU survival rates have been reported in critically ill patients with cancer in recent decades [3,4], they remain very low in patients with hematologic malignancies, in whom ICU mortality rates are 30% to 82% and in-hospital and long-term mortality rates are even higher [5][6][7][8][9][10][11][12][13][14][15].…”

Cross-validation of a Sequential Organ Failure Assessment score–based model to predict mortality in patients with cancer admitted to the intensive care unit

“…The score was originally developed in 1996 by Vincent et al [1] to evaluate organ failure in patients with sepsis, and it was later adopted by Peres Bota et al [2] in 2002 to predict mortality in critically ill patients in shock from different etiologies. Since then, many researchers have adopted [3][4][5][6][7] or advocated [8,9] for the use of the score to predict mortality of patients admitted to ICUs. In a systematic review of the literature on SOFA-based models by using the SCOPUS database, Minne et al [10] reported on 18 additional studies that specifically had evaluated SOFA score-based models to predict mortality in the ICU.…”

Infecções relacionadas à assistência em saúde e gravidade clínica em uma unidade de terapia intensiva

“…Estes dados revelam a importância do estabelecimento de medidas para prevenção das IRAS já que esta impacta diretamente no quadro do paciente e na ocorrência de óbitos. Além disso, a literatura revela que pacientes que apresentam índice de severidade clínica mais elevado frequentemente evoluem ao óbito (19)(20) .…”