Prognosis of sudden low-tone loss other than acute low-tone sensorineural hearing loss

Fushiki, Hiroaki; Junicho, Makiko; Kanazawa, Yuji; Aso, Shin; Watanabe, Yukio

doi:10.3109/00016480903311245

Cited by 28 publications

(22 citation statements)

References 14 publications

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“…Increasing evidence suggests that oxidative stress is involved in the development of endolymphatic hydrops and that cellular damage and apoptotic cell death might contribute to the sensorineural hearing loss found in later stages of MD [42]. Oxidation-reduction (redox) based regulation of gene expression appears to be a fundamental regulatory mechanism in cell biology.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress, Redox Homeostasis and Cellular Stress Response in Ménière’s Disease: Role of Vitagenes

et al. 2010

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Ménière's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on post-mortem examination. Increasing evidence suggests that oxidative stress is involved in the development of endolymphatic hydrops and that cellular damage and apoptotic cell death might contribute to the sensorineural hearing loss found in later stages of MD. While excess reactive oxygen species (ROS) are toxic, regulated ROS, however, play an important role in cellular signaling. The ability of a cell to counteract stressful conditions, known as cellular stress response, requires the activation of pro-survival pathways and the production of molecules with anti-oxidant, anti-apoptotic or pro-apoptotic activities. Among the cellular pathways conferring protection against oxidative stress, a key role is played by vitagenes, which include heat shock proteins (Hsps) as well as the thioredoxin/thioredoxin reductase system. In this study we tested the hypothesis that in MD patients measurable increases in markers of cellular stress response and oxidative stress in peripheral blood are present. This study also explores the hypothesis that changes in the redox status of glutathione, the major endogenous antioxidant, associated with abnormal expression and activity of carbonic anhydrase can contribute to increase oxidative stress and to disruption of systemic redox homeostasis which can be associated to possible alterations on vulnerable neurons such as spiral ganglion neurons and consequent cellular degeneration. We therefore evaluated systemic oxidative stress and cellular stress response in patients suffering from Meniere's disease (MD) and in age-matched healthy subjects. Systemic oxidative stress was estimated by measuring protein oxidation, such as protein carbonyls (PC) and 4-hydroxynonenal (HNE) in lymphocytes of MD patients, as well as ultraweak luminescence (UCL) as end-stable products of lipid oxidation in MD plasma and lymphocytes, as compared to age-matched controls, whereas heat shock proteins Hsp70 and thioredoxin (Trx) expression were measured in lymphocytes to evaluate the systemic cellular stress response. Increased levels of PC (P < 0.01) and HNE (P < 0.05) have been found in lymphocytes from MD patients with respect to control group. This was paralleled by a significant induction of Hsp70, and a decreased expression of Trx (P < 0.01), whereas a significant decrease in both plasma and lymphocyte ratio reduced glutathione GSH) vs. oxidized glutathione (GSSG) (P < 0.05) were also observed. In conclusion, patients affected by MD are under condition of systemic oxidative stress and the induction of vitagenes Hsp70 is a maintained response in counteracting the intracellular pro-oxidant status generated by decreased content of GSH as well as expression of Trx. The search for novel and more potent inducers of vitagenes will facilitate the development of pharmacological strategies to increase the intrinsic capacity of vulnerable ganglion cells to maximize antid...

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress, Redox Homeostasis and Cellular Stress Response in Ménière’s Disease: Role of Vitagenes

et al. 2010

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“…Some studies have also observed hearing loss recurrence [ 13 ] and percentage of recovery [ 4 ] after differing treatments. Fuse, et al [ 12 ] categorized hearing loss improvements using an audiometric definition, reporting that many ALHL patients achieved complete recovery between 7 and 10 days after administration of steroid.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnostic criteria for ALHL are not clearly defined, and different studies on ALHL appear to have established their own audiometric definition of ALHL [ 3 4 8 13 14 ]. For our study, we modified the audiometric definition of ALHL proposed by the Study Group for the Acute Profound Deafness Research Committee of the Ministry of Health, Labor and Welfare of Japan [ 3 ], as follows: 1) purely sensorineural hearing impairment with intact tympanic membranes; 2) no history of ocular, vestibular or brain injury; 3) 70 dB or greater sum of pure-tone audiogram hearing loss at three lower frequencies (125, 250, and 500 Hz) and 60 dB or less sum of hearing loss at three higher frequencies (2, 4, and 8 kHz); 4) no history of episodic vertigo or spontaneous nystagmus.…”

Section: Methodsmentioning

confidence: 99%

“…Several studies have compared the efficacy of various treatments-steroid alone, diuretic alone, or steroid and diuretic combined-for ALHL patients [ 3 4 12 13 14 ]. Some studies have categorized and compared treatment outcomes [ 3 12 ], while others have concentrated on ALHL prognosis, such as hearing loss recurrence [ 13 ] or percentage of recovery [ 4 ], after different treatments. However, few studies have compared improvements in hearing thresholds at each lower frequency (125, 250, and 500 Hz) after the administration of different treatments.…”

Section: Introductionmentioning

confidence: 99%

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Short-Term Outcomes of Acute Low-Tone Sensorineural Hearing Loss According to Treatment Modality

Chang

Yum

et al. 2016

J Audiol Otol

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Background and ObjectivesWe compared improvements in hearing thresholds in acute low-tone sensorineural hearing loss (ALHL) patients after two different treatments: steroid alone and steroid and diuretic combined. We analyzed how the duration between the onset of symptoms and the initiation of treatment affected hearing loss improvement and investigated the relation between presence of vertigo in ALHL patients and ALHL progression to Ménière's disease (MD).Subjects and MethodsWe retrospectively analyzed the medical records of 47 ALHL patients aged 21 to 76 years. Patients received either orally administered steroid alone (n=12) or steroid and diuretic combined (n=35). We compared improvements in the two groups' hearing thresholds at three lower frequencies (125, 250, and 500 Hz) after participants had received one month of each respective treatment.ResultsOur two treatments did not show any statistical difference in hearing loss improvement after one month. Forty percent of ALHL patients with vertigo developed MD, which was a significantly higher rate than the 12.5% of ALHL patients without vertigo who developed MD. The shorter duration between the onset of symptoms and the initiation of treatment significantly increased improvement in the sum of lower frequency hearing threshold after one month.ConclusionsThe current study suggests that steroid and diuretic administered together and steroid alone similarly improve the hearing threshold in ALHL patients after one month. We concluded that patients should initiate ALHL treatment as soon as they experience symptoms. ALHL patients should also be notified of their higher risk of developing MD.

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“…Second, group II patients may be associated with acute low-tone hearing loss without vertigo (ALTHL). The generally used audiometric definition of ALTHL is that the sum of the hearing levels at 125, 250, and 500 Hz should be greater than 70 dB and that the sum of the hearing levels at 2, 4, and 8 kHz, 60 dB or less [ 14 ]. Fushiki et al [ 14 ] reported that the mean age of patients with ALTHL was 37.8 years, which is younger than that of patients with low-tone SSNHL not belonging to the ALTHL group.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Sudden Sensorineural Hearing Loss With Minimal Hearing Impairment

Lee

Cho

2015

Clin Exp Otorhinolaryngol

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ObjectivesThe aim of the study was to determine the characteristics of patients who did not match the audiometric criteria of idiopathic sudden sensorineural hearing loss (SSNHL) but complained of acute hearing loss.MethodsBy thorough medical chart reviews, historical cohort study was performed with consecutive data of 589 patients complaining of acute unilateral sensorineural hearing loss without identifiable causes between 2005 and 2013. Those patients demonstrating a hearing loss of at least 30 dB at three consecutive frequencies based on pure tone audiometry were classified as group I; the others were classified as group II. Patients' characteristics, final hearing, and hearing improvement rate (HIR) between the two groups were compared.ResultsGroup II exhibited distinctive characteristics, including an early age of onset of the hearing loss (P<0.01), an absence of accompanying diabetes (P<0.01) and hypertension (P<0.01), and better unaffected hearing and final hearing compared with group I (P<0.001). However, the HIR of the patients in the two groups was not significantly different (P>0.05).ConclusionPatients who did not meet the audiological criteria of SSNHL exhibited distinctive characteristics compared to SSNHL patients.

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Prognosis of sudden low-tone loss other than acute low-tone sensorineural hearing loss

Cited by 28 publications

References 14 publications

Oxidative Stress, Redox Homeostasis and Cellular Stress Response in Ménière’s Disease: Role of Vitagenes

Oxidative Stress, Redox Homeostasis and Cellular Stress Response in Ménière’s Disease: Role of Vitagenes

Short-Term Outcomes of Acute Low-Tone Sensorineural Hearing Loss According to Treatment Modality

Idiopathic Sudden Sensorineural Hearing Loss With Minimal Hearing Impairment

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