Prognosis of the adenocarcinoma of the cervix uteri: A comparative study

Kleine, W.; Rau, Karin; Schwoeorer, Dietmar; Pfleiderer, Albrecht

doi:10.1016/0090-8258(89)90032-2

Cited by 81 publications

(11 citation statements)

References 19 publications

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“…This may be related to limited number of node-positive patients with adenocarcinoma of cervix. In some studies, similarly, a higher incidence of lymph node metastasis and decreased survival in adenocarcinoma compared to squamous cell carcinoma was reported when stage and tumor size were controlled (13,15,25) . In analysis of patients with metastatic lymph nodes, which included 111 with squamous cell carcinoma and 17 with adenocarcinoma, any statistically significant difference was found in survival between two cell types.…”

Section: Discussionmentioning

confidence: 86%

“…It is controversial whether or not patients with adenocarcinoma has poorer prognosis than patients with squamous cell carcinoma in stage IB cervical cancer. Several retrospective series suggest that survival was equivalent for patients with both cell types (4)(5)(6)(7)(8)(9)(10) ; while others noted that adenocarcinoma was related with poorer prognosis (3,(11)(12)(13)(14)(15) . In 1996, Gynecologic Oncology Group reported that survival was equivalent for patients with squamous cell carcinoma and adenocarcinoma of cervix; but adenosquamous carcinoma is associated with poorer prognosis (16) .…”

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confidence: 99%

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A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

Al¹,

Baykal²,

Demirtas³

et al. 2004

Int J Gynecol Cancer

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Objectives: The objective of this study was to compare clinical and pathologic variables and prognosis of FIGO stage IB adenocarcinoma and squamous cell carcinoma of uterine cervix.MethodsA retrospective review was performed of 521 patients with stage IB squamous cell carcinoma and adenocarcinoma of cervix who treated primarily by type 3 hysterectomy and pelvic and/or para-aortic lymphadenectomy at Hacettepe University Hospitals between 1980 and 1997.ResultsAge, tumor size, grade, depth of invasion, lymph node metastasis, parametrial, vaginal, and lymphvascular space involvement (LVSI) were not different between two cell types except number of the lymph nodes involved. Metastasis to three or more lymph nodes was significantly higher in adenocarcinoma. Overall and disease-free survival were 87.7%, 84.0% versus 86.4%, 83.1% for squamous cell carcinoma and adenocarcinoma, respectively (P > 0.05). The rate and site of recurrence were not different between two cell types. Multivariate analysis of disease-free and overall survival revealed independent prognostic factors as tumor size, LVSI, number of involved lymph node, and vaginal involvement.ConclusionPrognosis of FIGO stage IB cervical cancer patients who were treated by primarily radical surgery was found to be same for those with adenocarcinoma and squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 86%

mentioning

confidence: 99%

A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

Al¹,

Baykal²,

Demirtas³

et al. 2004

Int J Gynecol Cancer

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“…However, survival was not correlated with clinical stage (borderline significance), a finding that was consistent with a previous report. 3 Stepwise regression analysis revealed that the expression of p21 WAF1/CIP1 and negative lymph node metastasis were the best predictors of a favorable prognosis, and that the expression of p21 WAF1/CIP1 was almost as important as lymph node status in this respect. p21 WAF1/CIP1 , which is an inhibitor of G1 cdks, suppresses the cell cycle and inhibits DNA synthesis.…”

Section: Discussionmentioning

confidence: 95%

“…1 A poorer prognosis for cervical adenocarcinoma than for squamous cell carcinoma has been emphasized by some authors because of 1) the difficulty of diagnosing early glandular lesions, and 2) the lower sensitivity of the former to radiotherapy. 1,3 However, others have claimed that patients with these two types of cervical carcinoma have almost equal prognoses. 2,4 It has also been reported that the prognoses of patients with cervical adenocarcinoma are associated with the size of the tumor, the presence of pelvic lymph node metastases, the stage of the disease, and the grade of the tumor.…”

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confidence: 99%

Expression of p21WAF1/CIP1 in adenocarcinoma of the uterine cervix

Toki

Konishi

et al. 1998

Cancer

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“…Although it is controversial whether there is a difference in survival between women with squamous cell carcinoma and those with adenocarcinoma of the cervix, 15,16 it seems that the most significant difference in prognosis between the 2 types of cervical cancer occurs in patients with surgically detected pelvic lymph node metastasis. 5, 6 Nakanishi et al 6 analyzed the literature regarding prognosis of patients with cervical cancer treated surgically and concluded that the difference in prognosis between adenocarcinoma and squamous cell carcinoma depends on the ratio of node-positive cases with adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Adjuvant Chemotherapy for Node-Positive Cervical Adenocarcinoma

Takeshima

Utsugi

Hasumi

et al. 2009

Int J Gynecol Cancer

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We examined the effectiveness of postoperative adjuvant chemotherapy for node-positive cervical adenocarcinoma. During the period from 1994 to 2002, 98 consecutive patients with clinical stage I and II cervical adenocarcinoma were treated surgically without having undergone any prior treatment. Surgical procedures included radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy. Postoperatively, 21 patients were found to have lymph node metastasis, and all were treated with chemotherapy in the absence of radiotherapy. All patients were followed up for at least 5 years. Recurrence developed in 9 of the 21 patients, all 9 died of the disease. Six of the 9 recurrences were extrapelvic lesions. Five-year disease-free survival and overall survival were 57% and 67%, respectively. Recurrence was more common in patients with 6 or more positive nodes than in those with fewer than 3 positive nodes. These data suggest the potential role of postoperative chemotherapy for treatments of cervical adenocarcinoma. However, the effectiveness of chemotherapy alone in node-positive cervical adenocarcinoma was likely not as high as that in squamous cell carcinoma. Despite our use of postoperative chemotherapy in the absence of pelvic radiation, the disease recurred predominantly at distant sites.

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Prognosis of the adenocarcinoma of the cervix uteri: A comparative study

Cited by 81 publications

References 19 publications

A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma

Expression of p21WAF1/CIP1 in adenocarcinoma of the uterine cervix

Postoperative Adjuvant Chemotherapy for Node-Positive Cervical Adenocarcinoma

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