Prognostic Analysis of Gastric Signet Ring Cell Carcinoma and Hepatoid Adenocarcinoma of the Stomach: A Propensity Score-Matched Study

Yang, Yu Shih; Li, Yuxuan; Du, Xiaohui

doi:10.3389/fonc.2021.716962

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…This is particularly advantageous when the comparator groups are initially very different from each other and can achieve good balance and minimize the variances as shown in previous studies 15,16 . Several studies adopted this method to analyze the effect of sex, cancer type, monitoring or treatment on the outcome between groups with significant differences in baseline characteristics [16][17][18][19][20] . By employing this method, we could analyze the hazard ratio for the outcomes between two groups of CKD causes after adjusting for potential confounders.…”

Section: Discussionmentioning

confidence: 99%

Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD

Ryu

Hong²,

Park³

et al. 2023

Sci Rep

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The causes of chronic kidney disease (CKD) affects its outcomes. However, the relative risks for adverse outcomes according to specific causes of CKD is not well established. In a prospective cohort study from KNOW-CKD, a cohort was analyzed using overlap propensity score weighting methods. Patients were grouped into four categories according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), or polycystic kidney disease (PKD). From a total of 2070 patients, the hazard ratio of kidney failure, the composite of cardiovascular disease (CVD) and mortality, and the slope of the estimated glomerular filtration rate (eGFR) decline according to the cause of CKD were compared between causative groups in a pairwise manner. There were 565 cases of kidney failure and 259 cases of composite CVD and death over 6.0 years of follow-up. Patients with PKD had a significantly increased risk for kidney failure compared to those with GN [Hazard ratio (HR) 1.82], HTN (HR 2.23), and DN (HR 1.73). For the composite outcome of CVD and death, the DN group had increased risks compared to the GN (HR 2.07), and HTN (HR 1.73) groups but not to the PKD group. The adjusted annual eGFR change for the DN and PKD groups were − 3.07 and − 3.37 mL/min/1.73 m2 per year, respectively, and all of these values were significantly different than those of the GN and HTN groups (− 2.16 and − 1.42 mL/min/1.73 m2 per year, respectively). In summary, the risk of kidney disease progression was relatively higher in patients with PKD compared to other causes of CKD. However, the composite of CVD and death was relatively higher in patients with DN-related CKD than in those with GN- and HTN-related CKD.

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Section: Discussionmentioning

confidence: 99%

Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD

Ryu

Hong²,

Park³

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Subsequent investigations established that HAS may also manifest without elevated AFP levels ( 6 ), suggesting that elevated serum AFP serves as a hallmark of HAS but lacks absolute specificity. HAS is distinguished by its aggressive behavior and dismal prognosis in comparison to GA and HCC ( 3 , 7 – 9 ), with median survival ranging from 10 months to 18 months ( 10 , 11 ). Diagnosis often occurs at advanced stages, given the non-specific nature of clinical symptoms and imaging features.…”

Section: Introductionmentioning

confidence: 99%

Liver metastasis from hepatoid adenocarcinoma of the stomach: a case report and literature review

Zhu,

Li,

Qian

2024

Front. Oncol.

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Hepatoid adenocarcinoma of the stomach (HAS) represents a rare malignant neoplasm sharing morphological and immunophenotypic similarities with hepatocellular carcinoma (HCC). Pathological morphology serves as the cornerstone for diagnosis, often accompanied by elevated alpha-fetoprotein (AFP) levels, nonspecific clinical symptoms, and imaging features reminiscent of gastric adenocarcinoma (GA). Liver metastases from HAS can mimic the enhancement patterns of HCC, posing challenges in differentiation from high-risk HCC cases. Conversely, HAS typically exhibits poorer prognostic outcomes compared to HCC and GA. This report presents a case of HAS with liver metastasis alongside a comprehensive literature review covering its pathology, molecular mechanisms, clinical presentations, and treatment modalities. Special focus is given to imaging characteristics and the utilization of radiomics for early-stage detection. The integration of imaging findings with laboratory results aids in HAS diagnosis, while radiomics provides novel insights for precise discrimination. In conclusion, the identification of distinct imaging markers distinguishing HAS from HCC and GA shows promise in facilitating optimal treatment strategies and improving patient outcomes.

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Analysis of enhanced CT imaging signs and clinicopathological prognostic factors in hepatoid adenocarcinoma of stomach patients with radical surgery: a retrospective study

Yan,

Ju,

Hou

et al. 2023

BMC Med Imaging

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Background To investigate the association between CT signs and clinicopathological features and disease recurrence in patients with hepatoid adenocarcinoma of stomach (HAS). Methods Forty nine HAS patients undergoing radical surgery were retrospectively collected. Association between CT and clinicopathological features and disease recurrence was analyzed. Multivariate logistic model was constructed and evaluated for predicting recurrence by using receiver operating characteristic (ROC) curve. Survival curves between model-defined risk groups was compared using Kaplan–Meier method. Results 24(49.0%) patients developed disease recurrence. Multivariate logistic analysis results showed elevated serum CEA level, peritumoral fatty space invasion and positive pathological vascular tumor thrombus were independent factors for disease recurrence. Odds ratios were 10.87 (95%CI, 1.14–103.66), 6.83 (95%CI, 1.08–43.08) and 42.67 (95%CI, 3.66–496.85), respectively. The constructed model showed an area under ROC of 0.912 (95%CI,0.825–0.999). The model-defined high-risk group showed poorer overall survival and recurrence-free survival than the low-risk group (both P < 0.001). Conclusions Preoperative CT appearance of peritumoral fatty space invasion, elevated serum CEA level, and pathological vascular tumor thrombus indicated poor prognosis of HAS patients.

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Prognostic Analysis of Gastric Signet Ring Cell Carcinoma and Hepatoid Adenocarcinoma of the Stomach: A Propensity Score-Matched Study

Cited by 4 publications

References 27 publications

Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD

Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD

Liver metastasis from hepatoid adenocarcinoma of the stomach: a case report and literature review

Analysis of enhanced CT imaging signs and clinicopathological prognostic factors in hepatoid adenocarcinoma of stomach patients with radical surgery: a retrospective study

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