Prognostic Analysis of Schistosomal Rectal Cancer

Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer

“…The T stage and CA19-9 levels were independent prognostic factors of survival (46). In addition, Wang et al (47) analyzed 30 patients with schistosomal rectal cancer and showed that schistosomiasis was significantly associated with OS and schistosomiasis was an independent prognostic factor which predicted a less favorable disease-free survival and OS based on multivariate analysis.…”

Schistosoma japonicum–Associated Colorectal Cancer: A Review

“…11,22,26,27 The lesions not uncommonly exhibit multicentric and multifocal distribution, and are significantly larger in size relative to non-schistosomal CRC. 27,30,31,33,34 Age and gender ratios. Worldwide, the peak incidence of sporadic CRC occurs in the sixth and seventh decades of life; only 2-8% of CRC cases occur in people younger than 40 years.…”

“…It has been reported that the 5-year survival rate for patients with CRC complicated with schistosomiasis japonica was 45.6% of 430, which was significantly lower than that in those without schistosomiasis (50.9% of 2,717). 11 Wang et al 33 reviewed 30 patients with S. japonicum-associated rectal cancer and concluded that schistosomiasis was the only independent prognostic factor for worse disease-free survival and overall survival. In a subsequent analysis of 74 SACC patients by the same authors, it was demonstrated that the site of deposition of S. japonicum eggs in the colonic wall significantly correlated with the overall survival, although it did not independently predict survival.…”

Relationship between salt-inducible kinase 2 (SIK2) and lymph node metastasis in colorectal cancer patients complicated with chronic schistosomiasis

“…[ Key words ] Colorectal cancer; Schistosomiasis; Lymph node metastasis; Salt-inducible kinase 2; Schistosome egg 3-磷酸脱氢酶(glyceraldehyde-3-phosphate dehydrogenase，GAPDH)；3，3'-二氨基联苯 胺(3，3'-Diaminobenzidine，DAB)；AMP 活化蛋白激酶(AMP-activated protein kinase， AMPK) 结直肠癌是临床最常见的肿瘤之一，近年来 我国结直肠癌的发病率和病死率呈上升趋势 [1][2] 。 结直肠癌的发生是多种因素共同作用的结果，性 别、年龄、居住环境、遗传等都与肿瘤的发生具有 重要的相关性 [3][4] 。研究报道，我国长江流域发生 的慢性血吸虫病与结直肠癌具有重要联系，血吸 虫卵长期积聚在肠黏膜组织中引起慢性炎症，容 易导致肠黏膜发生癌变 [5] 。同时，有研究表明，慢 性血吸虫病可以促进结直肠癌发展，影响肿瘤生 长以及转移 [6] 。虽然目前有大量临床研究已经证 明慢性血吸虫病与结直肠癌存在相关性，但其发 生机制仍未明确 [7] 。最新研究报道，SIK2 可以通 过 Hippo-YAP 信号通路调控结直肠癌增殖和转 移 [8] ，而该信号通路对血吸虫诱发的肝脏纤维化 具有重要调控作用 [9] 。基于以上证据，本研究结 合结直肠癌患者的临床资料和病理诊断结果，探 究慢性血吸虫病影响结直肠发生发展的过程是否 与 SIK2 相关。 [10][11][12] ，也有研究认为 DNA 错配 修复基因hMLH1和hMSH2 的缺失是慢性血吸虫病 诱发结直肠癌的关键因素 [13][14] 。虽然目前关于慢 性血吸虫病与结直肠癌关系的研究很多，但两者 之间的确切关系以及机制仍然存在很大争议。 SIK 属于 AMPK 家族的一员 [15] ，具有 SIK1、SIK2、 SIK3 三种亚型，其中 SIK2 是一种新发现的肿瘤标 志物，在肿瘤组织中高表达，并在多种肿瘤的发 生、发展、侵袭、转移中扮演着重要角色 [16][17][18] 。本 研究旨在探究慢性血吸虫病对结直肠癌发生发展 的影响是否与 SIK2 的表达存在一定的相关性。…”