Prognostic and Predictive Value of Serum b-Type Natriuretic Peptide in Early Mortality and Morbidity of Children with Congenital Heart Disease after Open Heart Surgery

Arafa, Reda Sanad; Azab, Sherif; Sheta, Sahar; Kamal, Howyda M.; Nassar, Mithal

doi:10.21608/bjas.2020.136104

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low-risk open heart surgery in children is linked to higher preoperative NT-proBNP levels, which have been linked to postoperative problems such pleural effusion and infection. Additional research has connected elevated levels of NT-proBNP in children with congenital heart disease (CHD) to either left or right ventricular volume overload or dysfunction (13) . Studies in a range of adolescent cardiac illnesses demonstrate that natriuretic peptide levels rise in relation to the intensity of symptoms and the extent of remodeling .…”

Section: Table (7): Association Between Change Between Pre and Post-o...mentioning

confidence: 99%

Prognostic Value of NT-proBNP and 3 Months Readmission or Mortality after Congenital Heart Surgery

Zahran¹,

Zahran²,

Elghaffar³

2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: The use of NT-proBNP in predicting outcomes after juvenile congenital heart surgery is uncertain. Objective: We wanted to determine whether the novel biomarker NT-proBNP might be used to identify babies at increased risk of readmission or death after congenital heart surgery. Patients and Methods: This was a cross-sectional study done from April 2021 to January 2022, at Pediatric Intensive Care Units at Alhusien and Bab Alsharia University Hospitals. Our study included 100 patients in the pediatric and adolescent age group. Biomarkers were assessed using an enzyme-linked immunosorbent assay with patterned arrays and electrochemiluminescence detection. The manufacturer's specifications were respected while repurposing pre-owned kits and equipment. Results: Soluble suppression of tumorigenicity 2 pre and postoperative values were significantly associated with readmission. Postoperative NT-ProBNP values were significantly associated with readmission. Only preoperative soluble suppression of tumorigenicity 2 with cut-off value of 1.46 showed significant association with readmission with sensitivity and specificity of 84.6 and 79.3% respectively. Postoperative NT-ProBNP and soluble suppression of tumorigenicity 2 with cut-off values of 904.12 and 1.46 respectively showed significant association with readmission with sensitivity and specificity of 95.5% and 97.7% respectively for NT-ProBNP and sensitivity and specificity 84.6% and 74.7% respectively for soluble suppression of tumorigenicity 2. No laboratory parameter change showed significant association with readmission. Conclusion: Postoperative NT-proBNP levels were strongly related with readmission after juvenile congenital heart surgery, with good sensitivity and specificity.

show abstract

Section: Table (7): Association Between Change Between Pre and Post-o...mentioning

confidence: 99%

Prognostic Value of NT-proBNP and 3 Months Readmission or Mortality after Congenital Heart Surgery

Zahran¹,

Zahran²,

Elghaffar³

2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

show abstract

Prognostic and Predictive Value of Serum b-Type Natriuretic Peptide in Early Mortality and Morbidity of Children with Congenital Heart Disease after Open Heart Surgery

Cited by 1 publication

References 0 publications

Prognostic Value of NT-proBNP and 3 Months Readmission or Mortality after Congenital Heart Surgery

Prognostic Value of NT-proBNP and 3 Months Readmission or Mortality after Congenital Heart Surgery

Contact Info

Product

Resources

About