Prognostic and survival analysis of 837 Chinese colorectal cancer patients

Yuan, Ying; Li, Mo-Dan; Hu, Hanguang; Dong, Caixia; Chen, Jiaqi; Li, Xiaofen; Li, Jingjing; Shen, Houfa

doi:10.3748/wjg.v19.i17.2650

Cited by 51 publications

(53 citation statements)

References 44 publications

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“…The result of this study is consistent with the finding of our study. In a study from China in 2013, the 3year survival rate was reported 0.74 (Yuan et al, 2013). The 5-year survival rate in our study (Yeole et al, 2001) and in Malaysia in 2010 (Ghazali et al, 2010), the 5-year survival rate was reported 33.6 and 34.3 respectively.…”

Section: Discussionsupporting

confidence: 39%

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Maajani

Khodadost

Fattahi

et al. 2019

Asian Pac J Cancer Prev

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2015). CRC is one of the most common cancers in Iran, which has increased in recent years. The incidence of this cancer in Iran is lower than other developed countries; however, in-recent decades, this rate has increased significantly. According to national reports of Iran cancer registration in 2009, colorectal cancer is the third most common cancer in women and the fourth most common cancer in men

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Section: Discussionsupporting

confidence: 39%

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Maajani

Khodadost

Fattahi

et al. 2019

Asian Pac J Cancer Prev

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“…In most studies, the advanced age of patients with colorectal cancer, operated in emergency, was a risk factor (13)(14)(15), as in our study. Other studies have reported a poor prognosis in young patients with colorectal neoplasm.…”

Section: Discussionsupporting

confidence: 65%

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Constantin¹,

Firescu²,

Voicu³

et al. 2020

chr

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Introducere: În anul 2018 cancerul de colon se afla pe locul al 5-lea ca mortalitate prin cancer, iar cancerul rectal pe locul al 10-lea. Supravieţuirea la distanţă a bolnavilor cu cancer colorectal operat în urgenţă, rămâne nesatisfăcătoare, decesul fiind datorat recidivelor locale şi a metastazelor. Scopul: Evaluarea unor corelaţii ale supravieţuirii globale cu caracteristici clinico-paraclinice, tumorale sau de tratament pentru identificarea factorilor de prognostic la pacienţii cu cancer colorectal operat în urgenţă. Material şi Metode: Am efectuat o analiză retrospectivă la 431 pacienţi cu cancer colorectal operat în urgenţă în perioada 2008-2017, cu excluderea celor 40 de pacienţi cu decese postoperatorii, cu o perioadă de urmărire de cel puţin un an. S-au efectuat corelaţii ale unor caracteristici clinico-paraclinice, tumorale sau de tratament cu supravieţuirea globală. Rezultate: În analiza statistic univariată de supravieţuire, se obţine o asociere semnificativă statistic cu: vârsta > 61 ani (p_value = 0.000049), antecedentele chirurgicale abdominal (p_value = 0,031725), bolile cardiace (p_value = 0,000007), fibrilaţia atrială (p_value = 0,007496), diagnosticul la internare (p_value = 0,034352), caşexia (p_value = 0,000000), oligoanuria (p_value = 0,000000), anemia (p_value = 0,000006) dezechilibrul hidroelectrolitic (p_value = 0,000001), localizarea tumorală (p_value = 0,000030), invazia în organele vecine (p_value = 0,000000), aspectul de pelvis îngheţat (p_value = 0,000000), carcinomatoza peritoneală (p_value = 0,000000), metastazele hepatice (p_value=0,000000), tipul de intervenţie chirurgicală (p_value = 0,000000), limfodisecţia (p_value = 0,000001), biopsia hepatică (p_value = 0,043483), reintegrarea tranzitului intestinal (p_value = 0,000000), intervenţiile seriate (p_value = 0,000000), pTNM (p_value = 0,000000), gradingul (p_value = 0,007069). Analiza de regresie multivariată Cox a arătat că: vârsta > 61 ani-HR=1.026, 95%CI(1.012, 1.039) (p_value = 0.000139), caşexia-HR = 1.358, 95%CI(1.046, 1.764) (p_value = 0,021617), carcinomatoza peritoneală-HR = 2.346, 95%CI(1.163, 4.732) (p_value = 0,017253), stadiul bolii-HR=36.745, 95%CI = (14.778, 91.366) (p_ value = 0,000000), tipul de intervenţie-HR = 0.187, 95%CI(0.045, 0.779) (p_ value = 0,021281) şi intervenţiile seriate-HR = 0.282, 95% CI(0.144,0.551) (p_ value = 000213) sunt factori de prognostic independenţi. Concluzii: Factorii de prognostic pentru bolnavii cu cancere colorectale operate în urgenţă sunt: vârsta > 61 ani, prezenţa antecedentelor chirurgicale abdominale şi a tarelor cardiace asociate, în special a fibrilaţiei atriale, diagnosticul de iminenţă de perforaţie diastatică, caşexia, oligoanuria, anemia şi dezechilibrul hidro-electrolitic prezente la internare, tumorile rectale, invazia tumorală în organe vecine, aspectul de "pelvis îngheţat", prezenţa metastazelor hepatice sau a carcinomatozei peritoneale, tumorile nediferenţiate, stadiul III sau IV, practicarea unei derivaţii interne sau neefectuarea limfodisecţiei. Vârsta peste 61 de ...

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“…Notably, despite the limitation of the sample size, tobacco exposure, diagnostic stage and the selected NKR genotypes were all found to be significantly associated with the number of metastatic lymph nodes, which is well known to be one of the most important prognostic factors in CRC (14,15). SNPs in receptor-encoded genes can affect a number of aspects of receptor function (16), and may also result in an increased susceptibility to disease or produce variable responses to therapeutic agents (17).…”

Section: Discussionmentioning

confidence: 99%

Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients

Fang¹,

Fu²,

Chen³

et al. 2015

Oncology Letters

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Abstract.To analyze the single nucleotide polymorphisms (SNPs) of two subtypes of neurokinin (NK) receptors, NK1R and NK2R (also known as TAC1R and TAC2R), in colorectal cancer (CRC), peripheral blood samples were collected from 199 CRC patients. Direct-sequencing was performed to identify the NK1R rs10198644 and NK2R rs4644560 SNPs. Genotype results were correlated with clinical factors. The allele frequencies of NK1R rs10198644 GC, CC and GG were 52, 17 and 31%, respectively, while that of NK2R rs4644560 GC, CC, and GG were 36, 50 and 14%, respectively. Patients with NK2R rs4644560 GC exhibited more positive lymph nodes than those with CC (mean, 2.2 vs. 1.3; P=0.016). Further analysis highlighted that the number of positive lymph nodes was also increased in the NK2R rs4644560 GC/NK1R rs10198644 GG group compared with the NK2R rs4644560 GG/NK1R rs10198644 GG group (mean, 2.2 vs. 0.9; P=0.04). These data suggested that the NK2R rs4644560 GC polymorphism alone or combination with NK1R rs10198644 GG may be a promising prognostic marker of lymph node metastasis in CRC patients.

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Prognostic and survival analysis of 837 Chinese colorectal cancer patients

Abstract: The overall survival of CRC patients has improved between 1996 and 2006. LNR is a powerful factor for estimating the survival of stage III CRC patients.

Cited by 51 publications

References 44 publications

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients

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