Prognostic association of demographic and clinical factors with the change rates of symptoms and depression among patients with hepatocellular carcinoma

Chen, Jyh-Jou; Huang, Sheng‐Shiung; Li, In-Fun; Lin, Kuan-Pin; Tsay, Shiow‐Luan

doi:10.1007/s00520-019-04776-3

Cited by 8 publications

(8 citation statements)

References 41 publications

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“…66 67 68 Several studies that have addressed symptom burden as a stand-alone measure in HCC do provide some insight into levels at which introduction of palliative and supportive care may be beneficial, as detailed in the following. 69 70 71…”

Section: Evidence For Outcome Measures That Palliative and Supportive...mentioning

confidence: 99%

“…[66][67][68] Several studies that have addressed symptom burden as a stand-alone measure in HCC do provide some insight into levels at which introduction of palliative and supportive care may be beneficial, as detailed in the following. [69][70][71] In a Taiwanese prospective cohort study by Chen et al, 128 patients with HCC were recruited to undergo assessment of symptoms using the Edmonton Symptom Assessment Scale (ESAS) and depression using the Hospital Anxiety and Depression Scale (HADS) multiple times over a 6-month period. 69 This study showed that as BCLC stage progressed, patients were more likely to have symptoms, with older individuals having a higher symptom burden when compared with those who were younger.…”

Section: Symptoms In Hcc Patientsmentioning

confidence: 99%

“…[69][70][71] In a Taiwanese prospective cohort study by Chen et al, 128 patients with HCC were recruited to undergo assessment of symptoms using the Edmonton Symptom Assessment Scale (ESAS) and depression using the Hospital Anxiety and Depression Scale (HADS) multiple times over a 6-month period. 69 This study showed that as BCLC stage progressed, patients were more likely to have symptoms, with older individuals having a higher symptom burden when compared with those who were younger. An additional finding of the study showed that patients who were current smokers had higher rates of symptoms than their nonsmoker counterparts at similar BCLC stages.…”

Section: Symptoms In Hcc Patientsmentioning

confidence: 99%

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Early Implementation of Palliative and Supportive Care in Hepatocellular Carcinoma

2022

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Early palliative and supportive care referral is standard of care for many malignancies. This paradigm results in improvements in patients’ symptoms and quality of life and decreases the costs of medical care and unnecessary procedures. Leading oncology guidelines have recommended the integration of early referral to palliative and supportive services to care pathways for advanced malignancies. Currently, early referral to palliative care within the hepatocellular carcinoma (HCC) population is not utilised, with gastroenterology guidelines recommending referral of patients with Barcelona Clinic Liver Carcinoma (BCLC) D to these services. This review addresses this topic through analysis of existing data within the oncology field, as well as literature surrounding palliative care intervention in HCC. Early palliative and supportive care in HCC and its impact on patients, caregivers and health services, allows clinicians and researchers to identify management options that improve outcomes within existing service provisions.

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Section: Evidence For Outcome Measures That Palliative and Supportive...mentioning

confidence: 99%

Section: Symptoms In Hcc Patientsmentioning

confidence: 99%

Section: Symptoms In Hcc Patientsmentioning

confidence: 99%

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Early Implementation of Palliative and Supportive Care in Hepatocellular Carcinoma

2022

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“…In addition to physical symptoms, psychological symptoms are common in patients with cancer, including depression and sleep disturbance; however, they are often underassessed and undertreated 22 . Depressive symptoms are more common in patients with more advanced HCC and has been associated with longer survival 23,24 . A systematic review identified that patients with HCC have worse physical, emotional, and functional health‐related quality of life (QOL) compared with the general population 25 .…”

Section: Symptoms Experienced By Hepatocellular Carcinoma Patientsmentioning

confidence: 99%

Palliative care in hepatocellular carcinoma

Laube

Sabih

Strasser

et al. 2020

J of Gastro and Hepatol

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Hepatocellular carcinoma is a common cancer with a poor prognosis, associated with high economic costs and a significant burden of disease. While it is often asymptomatic in the early stages, patients may experience great discomfort from advanced disease, treatment adverse effects, or decompensation of underlying cirrhosis. Palliative care has the potential to markedly improve quality of life, physical, and psychological symptoms in patients with end‐stage liver disease, and has been shown to prolong survival in some nonhepatocellular carcinoma malignancies. However, this service is underutilized in hepatocellular carcinoma, and referrals are frequently late due to factors such as stigmatization, inadequate resources, lack of education for nonpalliative care physicians and inadequate modeling for integration of palliative and supportive care within liver disease services. In the future, education workshops, population‐based awareness campaigns, increased funding and improved models of care, may improve the uptake of palliative care and subsequently optimize patient care, particularly towards the end of life.

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“…Numerous studies have reported high depression incidence in cancer patients. A Taiwanese prospective study involving 128 newly diagnosed HCC patients found that advanced Barcelona Clinic liver cancer stage, radiofrequency ablation therapy, or liver resection was most closely associated with worsening physical and psychological symptoms over time [ 4 ]. Anxiety disorders and depression have also been associated with a significantly increased overall survival rate in HCC patients in a retrospective study involving 7304 patients treated for HCC from 1996 to 2010 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between hepatocellular carcinoma and depression via online database analysis

Han

Zhou

2021

Bioengineered

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There may be a mutually reinforcing relationship between hepatocellular carcinoma (HCC) and depression, but the mechanism is unknown. This study used bioinformatics to evaluate the relationship between HCC and depression at the genetic level. Genes associated with HCC and depression were obtained from pubmed2ensemble. Overlapping genes were annotated by gene ontology (GO) function and enriched by Kyoto Encyclopedia of Genes and Genomes (KEGG) signal pathway. The cluster-1 genes obtained by Cytoscape were analyzed by GEPIA for expression and overall survival in HCC and, finally, introduced target genes to DGIdb to get associated drugs. A total of 199 genes were found to be in common between HCC and depression. GO term enrichment analysis on DAVID found the top-6 biological processes to be mainly associated with cell death and apoptosis. The top-6 cellular component terms are extracellular. The top-6 of molecular function terms are mainly associated with receptor binding. The top-6 pathways enriched by KEGG are mainly related to inflammatory response. IGF1, VEGFA, and SERPINE1 had statistical differences in expression and 10-year survival rate. There are total 45 drugs that act on VEGFA and SERPINE1. Based on our findings, we hypothesize that the mechanism of the interaction between HCC and depression may be related to cell death or apoptosis. Further studies are needed to verify this hypothesis.

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Prognostic association of demographic and clinical factors with the change rates of symptoms and depression among patients with hepatocellular carcinoma

Cited by 8 publications

References 41 publications

Early Implementation of Palliative and Supportive Care in Hepatocellular Carcinoma

Early Implementation of Palliative and Supportive Care in Hepatocellular Carcinoma

Palliative care in hepatocellular carcinoma

Relationship between hepatocellular carcinoma and depression via online database analysis

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