Prognostic Efficacy of High-Sensitivity C-Reactive Protein to Albumin Ratio in Patients with Acute Coronary Syndrome

Abstract

Aim: The present study aimed to examine the correlation between high-sensitivity CRP to albumin ratio (CAR) and in-hospital and short-term major adverse cardiac events (MACEs) in patients with acute coronary syndrome (ACS). Materials & methods: We analyzed 652 consecutive patients who had been hospitalized for ACS. The MACEs were defined as cardiogenic shock, reinfarction, acute heart failure and all-cause death. Results: The incidence rate of MACEs was significantly higher in the high CAR (≥0.114) group than in the low CAR (<0.114) group. Multivariate analysis revealed that CAR, hs-CRP and albumin were independent predictors for increased risk for MACEs. Conclusion: The CAR was independently correlated with in-hospital and short-term MACEs and can be used for risk stratification in patients with ACS.

Predictive Value of C-Reactive Protein to Albumin Ratio in ST-Segment Elevation Myocardial Infarction Patients Treated With Primary Percutaneous Coronary Intervention

“…7,8 However, there are limited data on the correlation between CAR and major adverse cardiac events (MACEs) in STEMI patients undergoing primary percutaneous coronary intervention (pPCI). 9 In the present study, we investigated the predictive performance of CAR for 6-month MACEs in STEMI patients after pPCI. We also evaluated its incremental prognostic value for MACEs beyond the original GRACE score for 6 months postdischarge.…”

Predictive utility of the C-reactive protein to albumin ratio in early allograft dysfunction in living donor liver transplantation: A retrospective observational cohort study

“…CRP and ALB have been studied widely in various clinical settings and have been recognized as valuable prognostic markers for outcomes across various diseases, including sepsis, neoplasia, critical illness after intensive care unit (ICU) admission, and hospital-acquired acute kidney injury [28–32]. The CRP/ALB ratio, a combined index of the ALB and CRP levels, is known to be related more consistently to prognosis than is CRP or ALB alone, and it may accurately reflect the degree of inflammation or nutritional deficiency [13,14,33,34]. However, as the pathological mechanisms of ESLD (i.e., hepatic insufficiency and/or malnutrition) may negatively influence CRP and ALB production, cirrhotic patients have always been excluded from previous studies [13,14,25].…”

Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

“…The CAR is a marker that is calculated by the ratio of these acute phase markers; and is believed to be more sensitive in predicting inflammatory events. In some CVD (such as stable angına pectoris and acute coronary syndromes), CAR values were higher than in control groups and disease severity was associated with CAR values ( 7 , 8 , 9 ). In our study, ischemia group in MPS had significantly higher CAR values than those without ischemia.…”

“…The CRP to albumin ratio (CAR) is a new marker, which is calculated by the ratio of these acute phase reactants. CAR is thought to be better at predicting inflammatory events ( 7 , 8 , 9 ). This study was aimed to investigate the predictability of ischemia from inflammatory markers, before performing MPI in stable CAD patients.…”