Prognostic evaluations of small size lung cancers by 18F-FDG PET/CT and thin-section CT

Kishimoto, Mitsumasa; Iwano, Shingo; Ito, Shinji; Katô, Katsuhiko; Ito, Rintaro; Naganawa, Shinji

doi:10.1016/j.lungcan.2014.09.006

Cited by 25 publications

(28 citation statements)

References 19 publications

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“…Non-solid tumours usually represent well-differentiated adenocarcinomas. 3 Second, we used a fixed iodinated contrast agent volume rather than a patient body weight-determined contrast agent volume in this study, while contrast media of three iodine concentrations (300, 320 and 370 mgI) were assigned by body weight. This can result in lower enhancement in patients with heavier weight $60 kg.…”

Section: Discussionmentioning

confidence: 99%

“…For pre-operative evaluation, 18 F-fludeoxyglucose (FDG) positron emission tomography/ CT (PET/CT) associated with tumour glucose metabolism has been widely used to determine invasiveness and to make prognostic predictions in patients with lung cancer. [3][4][5][6] Contrast-enhanced CT has also been used for functional imaging to evaluate intratumoral necrosis, vascularity and fibrosis, which are associated with invasiveness and prognosis. [7][8][9][10][11][12] In the past, both non-contrast and contrast CT were required to quantify contrast enhancement of a tumour.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation

Iwano¹,

Ito²,

Umakoshi³

et al. 2015

BJR

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation

Iwano¹,

Ito²,

Umakoshi³

et al. 2015

BJR

Self Cite

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“…Given the difference in treatment strategies, accurate staging of SCLC is crucial. However, data concerning the use of 18 F-FDG PET/CT for SCLC staging [25,28,29,[82][83][84][85][86][87], radiotherapy planning [82,83], therapy response evaluation [88][89][90], and prognosis [89][90][91][92][93][94] are limited.…”

Section: Sclcmentioning

confidence: 99%

Present and future roles of FDG-PET/CT imaging in the management of lung cancer

et al. 2016

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Integrated positron emission tomography/computed tomography (PET/CT) using 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) has emerged as a powerful tool for combined metabolic and anatomic evaluation in clinical oncologic imaging. This review discusses the utility of (18)F-FDG PET/CT as a tool for managing patients with lung cancer. We discuss different patient management stages, including diagnosis, initial staging, therapy planning, early treatment response assessment, re-staging, and prognosis.

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“…In the study by Tsurugai et al, metabolic values like SUVmax on FDG‐PET/CT was a significant imaging biomarker that was relevant to the prognosis of patients with lung cancers of 3 cm in diameter. Multivariate regression analysis demonstrated that SUVmax was superior to the C / T ratio for predicting postoperative recurrence, particularly for solid type lung cancer . In an another study with early stage NSCLC treated with stereotactic body radiation, while DFS was significantly related with C / T ratio, OS did not show any difference according to 0.50 cut‐off value of C / T ratio in multivariate analyses .…”

Section: Discussionmentioning

confidence: 92%

Prognostic significance of preoperative consolidation to maximum tumour diameter ratio and SUVmax in pathological stage I lung adenocarcinoma

Kabalak¹,

Yılmaz²,

Ertürk³

et al. 2019

Clinical Respiratory J

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Objectives: Consolidation/tumour (C/T) ratio means the maximum diameter of the consolidation is divided by the maximum diameter of the tumour and it is predictive for pathologic subtypes and prognosis after resection of the tumour. The purpose of this study is to clarify impact of C/T ratio along with maximum standardized uptake value (SUV) in pathological stage I lung adenocarcinoma. Methods: Only patients with pathological stage I lung adenocarcinoma diagnosed by resection were included. Prognostic impact of C/T ratio and SUVmax were analysed by using regression analyses. Results: Totally 156 patients (121 males, 35 females) were evaluated retrospectively. Overall survival (OS) and progression free survival (PFS) were higher in patients with C/T ratio ≥0.5 (OS: 46.3 ± 23.7 vs 30.4 ± 14.6, P = 0.002 and PFS: 43.0 ± 25.4 vs 27.8 ± 15.8, P = 0.005). But PFS and OS curves did not reveal any significant differences with Kaplan-Meier method (P = 0.45 and P = 0.055 respectively). Resection type (limited vs anatomic) and C/T ratio were predictors for OS in multivariate analyses (resection type: HR: 2.21 (1.01-4.83), P = 0.045 and C/T ratio: HR: 0.44 (0.20-0.98), P = 0.045). For PFS, resection type and SUVmax had prognostic significance (resection type: HR: 3.56 (1.64-7.74), P = 0.001 and SUVmax: HR: 1.31 (0.82-2.99), P = .002). Conclusion: In pathological stage 1 lung adenocarcinomas, SUVmax and surgery type are important predictors for recurrence rates. For early stage, adenocarcinomapatients with high SUVmax value, tumour size ≥3 cm and high grade subtype, C/T ratio should not be considered significant alone on survival and recurrence. K E Y W O R D SConsolidation/tumour ratio, lung adenocarcinoma, prognosis, recurrence, SUVmax 72 | AKIN KABALAK et AL.

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Prognostic evaluations of small size lung cancers by 18F-FDG PET/CT and thin-section CT

Cited by 25 publications

References 19 publications

Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation

Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation

Present and future roles of FDG-PET/CT imaging in the management of lung cancer

Prognostic significance of preoperative consolidation to maximum tumour diameter ratio and SUVmax in pathological stage I lung adenocarcinoma

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