Prognostic factors and assessment of staging systems for head and neck soft tissue sarcomas in adults

Damme, Jean Philippe van; Schmitz, Sandra; Machiels, Jean‐Pascal; Galant, Christine; Grégoire, Vincent; Lengelé, Benoît; Hamoir, Marc

doi:10.1016/j.ejso.2010.05.020

Cited by 46 publications

(49 citation statements)

References 26 publications

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“…Five-year overall survival is better in low-grade tumor and is improved by negative margins. Van Damme et al reported 92 months' median disease-free survival after R0 resection, versus 14 months after R1 and 13 months after R2 [31]. The influence of tumor size is less clear.…”

Section: Survival and Prognostic Factorsmentioning

confidence: 91%

“…HNSTS shows low rates of adenopathy at diagnosis: 7% for Van Damme et al [31], 8.5% for Tran et al [16], and 10% for De Bree et al [26], with debated impact on local control and survival. Most authors therefore do not recommend systematic lymph-node surgery [3]: neck dissection is to be performed only if necessary, in case of clinical or radiological adenopathy.…”

Section: Treatmentmentioning

confidence: 97%

“…Finally, the low incidence of sarcoma means that most large series covered cases arising over several decades, with the consequent changes in treatment modalities. Table 1 Five-year overall and specific survival in the main HNSTS series [3,[11][12][13][15][16][17][18][19]26,[28][29][30][31][32][33]. Margin status is the most commonly reported predictive factor for local control.…”

Section: Survival and Prognostic Factorsmentioning

confidence: 99%

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Head and neck soft-tissue sarcoma in adults

Galy-Bernadoy

Garrel

2016

European Annals of Otorhinolaryngology, Head and Neck Diseases

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Adult soft-tissue sarcoma is rare but aggressive, with incidence around 5 per 100,000 per year. Head and neck locations are infrequent. Genetic disease and irradiation are risk factors. The diagnosis needs to be known in order to avoid treatment delay. There are about 50 histologic subtypes, with different patterns and prognoses. Pathologic review and the development of molecular techniques are therefore essential. Prognosis in adult head and neck soft-tissue sarcoma (HNSTS) is poor: 5-year overall survival, about 60%. Recurrence is most often local. Prognostic factors are: tumor size and local extension, histologic grade and margin status. There are few targeted management guidelines. Surgical resection with negative margins is the primary treatment. Postoperative radiation therapy can improve prognosis. The role of chemotherapy is not well established. HNSTS should be treated in a reference center, with multidisciplinary staff following national network guidelines. Several factors are still unknown. The purpose of this article is to summarize the state of knowledge in adult HNSTS.

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Section: Survival and Prognostic Factorsmentioning

confidence: 91%

Section: Treatmentmentioning

confidence: 97%

Section: Survival and Prognostic Factorsmentioning

confidence: 99%

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Head and neck soft-tissue sarcoma in adults

Galy-Bernadoy

Garrel

2016

European Annals of Otorhinolaryngology, Head and Neck Diseases

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“…Staging is performed according to the American Joint Committee on Cancer (AJCC) staging, which defines four clinical stages (I-IV), 8,9 and a second classification system proposed by Memorial Sloan-Kettering Cancer Center (MSKCC). 10 The evolution of disease in head and neck soft tissue sarcomas (HNSTS) frequently involves metastases, most commonly lung metastases. As such, initial management includes a chest X-ray or computed tomography scan.…”

mentioning

confidence: 99%