Prognostic Factors and Survival in Node-Positive (N1) Prostate Cancer—A Prospective Study Based on Data from a Swedish Population-Based Cohort

Aus, Gunnar; Nordenskjöld, Kerstin; Robinson, David; Rosell, Johan; Varenhorst, Eberhard

doi:10.1016/s0302-2838(03)00156-8

Cited by 26 publications

(13 citation statements)

References 15 publications

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“…[1][2][3][4][5] However, both surgeon-and patient-related factors may affect the outcomes of PLND. In particular, surgical experience plays a crucial role.…”

Section: Discussionmentioning

confidence: 99%

“…1 In addition, PLND has been shown to be curative, or at least beneficial, in patients with limited lymph node metastases. [2][3][4][5] Concerning the surgical approach, a recent systematic review of the literature clearly demonstrated that the PLND during robot-assisted radical prostatectomy(RARP) can be performed effectively and safely, providing similar outcomes compared to pure laparoscopic and open procedures. [6][7][8][9] Moreover, several factors, including prior experience in open and/or laparoscopic surgery, type of training and surgical volume, may affect the results of PLND.…”

Section: Introductionmentioning

confidence: 99%

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Extended pelvic lymph node dissection at the time of robot-assisted radical prostatectomy: impact of surgical volume on efficacy and complications in a single-surgeon series.

Pierro¹,

Grande²,

Wirth³

et al. 2015

CUAJ

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Introduction:We assessed the impact of surgical volume on perioperative outcomes and complications of robotic extended pelvic lymph node dissection (ePLND). 16 [range: 8-42] in Groups 1 to 4, respectively, p = 0.001). Tumour lymph node involvement was 12% in Groups 1 and 2, 7% in Group 3 and 9% in Group 4 (p = 0.075). Overall, 115 complications were reported in 98/233 patients (42%), with a significant decrease after 175 cases (p = 0.028). In Group 4, 3 patients reported an ePLND-related bleeding requiring open revision. Lymphoceles were detected in 10/233 patients (4.2%) and 1 patient (1.7%) in each of the Groups 2 to 4 required a percutaneous drainage. Conclusions: A surgeon with extensive experience is expected to achieve a safe learning curve for ePLND during RARP. A learning curve of 60 cases is suggested for optimal lymph node yield.

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“…[1][2][3][4][5] However, both surgeon-and patient-related factors may affect the outcomes of PLND. In particular, surgical experience plays a crucial role.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extended pelvic lymph node dissection at the time of robot-assisted radical prostatectomy: impact of surgical volume on efficacy and complications in a single-surgeon series.

Pierro¹,

Grande²,

Wirth³

et al. 2015

CUAJ

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show abstract

“…Tenyear cause-specific survival was 45%, 14 with a 10-year biochemical failure-free survival rate of 25%. 13 Our results were similar with a 37% 10-year survival and 49% 10-year biochemical failure-free survival for AA alone.…”

Section: Discussionmentioning

confidence: 99%

“…The two largest studies 13,14 with primary AA reported 10-year survival rates of 30 and 46%, respectively. Tenyear cause-specific survival was 45%, 14 with a 10-year biochemical failure-free survival rate of 25%.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcome for lymph node-positive prostate cancer

Swanson

Riggs

Herman

2007

Prostate Cancer Prostatic Dis

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Although the number of men with lymph node-positive prostate cancer has declined, it is still significant and the challenge remains on how best to treat these patients. Only long-term follow-up can give a true indication of the outcome in prostate cancer. We evaluated our experience in treating lymph node-positive prostate cancer with a median follow-up of 10.2 years. The overall 5-year survival was 78% and the 10-year survival was 56%. Length of tumor control depends on the type of treatment given. Adding androgen ablation improves the duration of control dramatically, although optimal timing is still uncertain.

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“…Das Gesamtüberle-ben nach 5 und 10 Jahren betrug 84% und 64% für die Prostatektomiegruppe im Vergleich zu nur 60% und 28% für die Gruppe der alleinigen Lymphadenektomie. In einer schwedischen Populationsstudie an 181 Männern mit lymphknotenpositivem PCA vertreten Aus et al [9] die Meinung, dass eine alleinige endokrine Therapie bei einem mittleren tumorspezifischen Überleben von knapp 8 Jahren die Behandlung der Wahl darstellen sollte. Die Autoren fanden keinen signifikanten Überlebensbenefit in Abhängig-keit vom Alter oder dem PSA-Wert.…”

Section: > Fehlender Therapeutischer Effekt Einer Alleinigen Androgenunclassified

Nodal-positives Prostatakarzinom

Heidenreich

Schrader²

2010

Urologe

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The current review article critically discusses the potential advantages and disadvantages of radical prostatectomy in patients with locally advanced lymph node-positive prostate cancer. It is the purpose of the manuscript to develop a therapeutic algorithm for management of these patients to achieve optimal oncological and functional results. Based on the data in the literature radical prostatectomy as part of a multimodality approach seems to be indicated in the following clinical scenario: limited intrapelvic lymph node metastasis without bulky disease; complete resectability of the primary cancer and metastases by extended radical prostatectomy and extended pelvic lymphadenectomy; inclusion of the patient in a multimodality approach; life expectancy > 10 years. In patients with extensive locally advanced PCA or large pelvic metastases, radical prostatectomy might be indicated to improve local cancer control and to prevent significant local and supravesical complications. In these cases, the indication for extensive surgery includes radical cystoprostatectomy and should be discussed in an interdisciplinary tumour board.

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Prognostic Factors and Survival in Node-Positive (N1) Prostate Cancer—A Prospective Study Based on Data from a Swedish Population-Based Cohort

Cited by 26 publications

References 15 publications

Extended pelvic lymph node dissection at the time of robot-assisted radical prostatectomy: impact of surgical volume on efficacy and complications in a single-surgeon series.

Extended pelvic lymph node dissection at the time of robot-assisted radical prostatectomy: impact of surgical volume on efficacy and complications in a single-surgeon series.

Long-term outcome for lymph node-positive prostate cancer

Nodal-positives Prostatakarzinom

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