Prognostic factors for ovarian metastases in colorectal cancer patients

Abstract

Purpose: The aim of this study was to analyze prognostic factors for ovarian metastases (OM) in colorectal cancer (CRC) using data from a Chinese center. In addition, the study aimed at developing a new clinical scoring system for prognosis of OS of CRC patients after surgery. Patients and methods: Data of CRC patients with OM were collected from a single Chinese institution (n = 67). Kaplan-Meier analysis was used to evaluate cumulative survival of patients. Factors associated with prognosis of overall survival (OS) were explored using Cox’s proportional hazard regression models. A scoring system for determine effectiveness of prognosis was developed.Results: Median OS values for patients with or without surgery were 22 and 7 months, respectively. Size of OM, number of OM, Peritoneal Metastasis (PM), Peritoneal Cancer Index (PCI), completeness of cytoreduction (CC) were associated with OS of patients through univariate analysis. Multivariate analysis using a Cox regression model showed that only CC was an independent predictor for OS. Three variables, (the size of OM >15cm, PCI ≥ 10, and carcinoembryonic antigen (CEA) >40 ng/mL) assigned one point each were used to develop a risk score. The resulting score was used for prognosis of OS.Conclusion: Surgical treatment of metastatic sites is effective and safe for CRC patients with OM. CC-0 is recommended for improved prognosis. The scoring system developed in this study is effective for prediction of OS of patients after surgery.