Prognostic Factors for Relapse and Pelvic Lymph Node Metastases in Early Stage I Adenocarcinoma of the Cervix

Covens, Al; Kirby, JA; Shaw, Patricia; Chapman, William; Franseen, E.

doi:10.1006/gyno.1999.5466

Cited by 31 publications

(12 citation statements)

References 9 publications

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“…Until now the United States and European researches have stated that early stage adenocarcinoma of cervix has metastasis, recurrence, and survival rates comparable to those of SCCA. Hence, surgical procedures in each stage of these two types of cervical cancer are similar (Covens et al, 1999;Poynor et al, 2006;Bisseling et al, 2007;Gien et al, 2010;Spoozak et al, 2012). These are consistent with the present study that the rate of residual diseases between SCCA and non-SCCA is not significantly different.…”

Section: Discussionsupporting

confidence: 91%

Residual Disease Following Conization of Women with Stage IA-IB1 Cervical Carcinoma in a High Incidence Region

Chatchotikawong

Ruengkhachorn²,

Leelaphatanadit³

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 91%

Residual Disease Following Conization of Women with Stage IA-IB1 Cervical Carcinoma in a High Incidence Region

Chatchotikawong

Ruengkhachorn²,

Leelaphatanadit³

2014

Asian Pacific Journal of Cancer Prevention

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“…Comparison of the two groups was made by Wilcoxon's signed rank test. Statistically significant differences were not observed in this study, but when our data were combined with previously reported results [6-8,12], statistically significant differences were observed between tumor volume and frequency of pelvic lymph node metastasis (p<0.0001) and between tumor volume and rate of recurrence (p<0.0001), using a tumor volume of ≤500 mm 3 as a cut-off (Table 2). LVSI was present in 11 cases, and three of these 11 cases were positive for pelvic lymph node metastasis.…”

Section: Resultssupporting

confidence: 63%

“…Many studies have evaluated FIGO stages IA1 and IA2 adenocarcinoma of the cervix. However, only four papers [6-8,12] compared tumor volume of early invasive adenocarcinoma of the cervix and lymph node metastasis or recurrence. Moreover, tumor volume was calculated using the Burghardt method in all four reports: depth×horizontal spread×1.5 the greater value for either depth or horizontal spread.…”

Section: Discussionmentioning

confidence: 99%

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Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix

et al. 2012

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ObjectiveThe aim of this study was to investigate the risk and recurrence of early invasive adenocarcinoma of the cervix, and to determine whether non-radical methods of management could be performed.MethodsThe medical and histopathological records of 50 patients with early invasive adenocarcinoma of the cervix treated at Keio University Hospital between 1993 and 2005 were reviewed, and compared with the literature.ResultsThe median follow-up period was 64.3 months. The depth of stromal invasion was ≤3 mm in 33 cases and >3 mm, but ≤5 mm in 17 cases. The horizontal spread was ≤7 mm in 25 cases and >7 mm in 25 cases. One of the 33 cases that had tumor volumes of ≤500 mm3, and three of the 17 cases with tumor volumes of >500 mm3 were positive for lymph node metastasis. When our data were combined with previously reported results, statistically significant differences were observed between the tumor volume and the frequency of pelvic lymph node metastasis/the rate of recurrence (p<0.0001). The frequency of pelvic lymph node metastases was significantly higher in the lymphovascular space invasion (LVSI)-positive group than in the LVSI-negative group (p=0.02). No adnexal metastasis or parametrial involvement was noted.ConclusionAssessment of the depth of stromal invasion, tumor volume, and LVSI is critical for selecting an appropriate therapeutic modality. Non-radical methods of management are considered suitable for patients with LVSI-negative adenocarcinoma of the cervix exhibiting a stromal invasion depth of ≤5 mm and a tumor volume of ≤500 mm3.

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“…Tumorvolumen Ein Tumorvolumen von 600 mm 3 und mehr ist mit einer hohen Progressions-, Metastasierungs-und Rezidivgefahr verbunden [9].…”

Section: Tab 1 Risikofaktoren Für Die Progression Und Das Rezidivierunclassified

Das Plattenepithelkarzinom des kleinen Beckens nach zurückliegender Hysterektomie bei Benignität des Uterus - Kasuistiken und differenzialdiagnostische Darstellung

Siggelkow¹,

Faridi²,

Rudlowski³

et al. 2001

Geburtsh u Frauenheilk

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ZusammenfassungFragestellung: Wir berichten von zwei Patientinnen, die in unserer Klinik an einem Plattenepithelkarzinom des kleinen Beckens operiert wurden. Die Hysterektomie der Patientinnen lag 14 bzw. 22 Jahre zurück, durch die damalige histologische Aufarbeitung der Uteruspräparate wurde sowohl ein Zervix-als auch ein Endometriumkarzinom ausgeschlossen. Jetzt entsprach das Ausbreitungsmuster der Karzinome am ehesten einem Zervixkarzinom. Beide Patientinnen wurden makroskopisch tumorfrei operiert und erhielten anschlieûend eine kombinierte Radiochemotherapie. Die HPV-Diagnostik wurde in beiden Fällen mit der PCR-Sequenzierung vorgenommen. Material und Methode: Diese Kasuistiken führen zu der Frage, welche Möglichkeiten der primären und der rezidivierenden Entstehung eines squamös differenzierten Karzinoms im kleinen Becken bei bereits entferntem Uterus bestehen. Schlussfolgerungen: Die Wahrscheinlichkeit eines Tumorrezidivs nach einem primär nicht erkannten frühinvasiven Zervixkarzinom liegt in Abhängigkeit von der Invasionstiefe zwischen 1 % bei einer Invasion von weniger als 3 mm und 5 % für Invasionstiefen von 3 ± 5 mm. Plattenepithelkarzinome betreffen 90 % der Malignome der Scheide. Wenn auch viel seltener als ein Zervixkarzinom, treten diese Tumoren zu 50 % nach vorheriger Hysterektomie auf. Seltene Entstehungsorte für Plattenepithelkarzinome des kleinen Beckens sind das Endometrium und die Ovarien. Plattenepitheliale Metaplasien der ableitenden Harnwege können in 25 ± 33 % der Fälle zu einem Plattenepithelkarzinom führen, die des Peritoneums sind als Raritäten bekannt, jedoch nie als Malignome beschrieben worden. Eine weitere Differenzierungsmöglichkeit des Tumorursprungs ist die HPVDiagnostik am Tumorgewebe. SummaryWe describe two patients with disseminated squamous cell carcinoma in the pelvis 14 and 22 years after hysterectomy for benign reasons. Tumor spread was consistent with squamous cell carcinoma of the cervix. Both patients underwent complete surgical removal of all gross tumor and received postoperative radiochemotherapy. The differential diagnosis of squamous cell carcinoma in the pelvis after remote hysterectomy for benign indications includes recurrent cancer of the cervix or endometrium, vaginal cancer, squamous cell carcinoma of the ovary, and carcinoma arising from squamous metaplasia of the urogenital tract.

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Prognostic Factors for Relapse and Pelvic Lymph Node Metastases in Early Stage I Adenocarcinoma of the Cervix

Cited by 31 publications

References 9 publications

Residual Disease Following Conization of Women with Stage IA-IB1 Cervical Carcinoma in a High Incidence Region

Residual Disease Following Conization of Women with Stage IA-IB1 Cervical Carcinoma in a High Incidence Region

Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix

Das Plattenepithelkarzinom des kleinen Beckens nach zurückliegender Hysterektomie bei Benignität des Uterus - Kasuistiken und differenzialdiagnostische Darstellung

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