Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjögren's syndrome

Chung, Jung Kee; Kim, Mee Kum; Wee, Won Ryang

doi:10.1136/bjo.2011.202812

Cited by 36 publications

(25 citation statements)

References 23 publications

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“…One small study found excess pulmonary disease among patients with rheumatoid factor (70), while IgA rheumatoid factor was associated with renal disease in another cohort (71). The presence of rheumatoid factor was a marker of more severe exocrine gland manifestations (keratoconjunctivitis sicca) among 121 Sjögren’s patients followed at least one year (72). Thus, rheumatoid factor is a prognostic finding in Sjögren’s but may not be useful for clinical diagnosis or research classification purposes because this antibody is found commonly in other diseases.…”

Section: Rheumatoid Factormentioning

confidence: 99%

Autoantibodies in Sjögren’s Syndrome

Fayyaz

Kurien

Scofield

2016

Rheumatic Disease Clinics of North America

172

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Our purpose was to compile information on antibodies in Sjögren’s syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. During our search of the English-language MEDLINE sources, we did not place a date-of-publication constraint. Hence, we have reviewed previous as well as most recent studies with the subject heading Sjogren’s in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren’s. We have discussed studies concerning the presence of antibodies predating clinical manifestations of disease. We have considered, in addition to anti-Ro/SSA and anti-La/SSB, anti-centromere antibody (ACA), anti-mitochondrial antibody (AMA) and many novel autoantibodies that have been analyzed in the literature. Studies in the future are required to ascertain the pathogenic mechanisms associated with these antibodies and the specific clinical manifestation related to new autoantibodies.

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Section: Rheumatoid Factormentioning

confidence: 99%

Autoantibodies in Sjögren’s Syndrome

Fayyaz

Kurien

Scofield

2016

Rheumatic Disease Clinics of North America

172

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“…High titers of anti-Ro and anti-La antibodies also have been shown to be associated with a greater incidence of extraglandular manifestations, especially purpura, leukopenia, and lymphopenia [23, 24]. …”

Section: Anti-ro Antibodies and Autoimmune Diseasesmentioning

confidence: 99%

Clinical and Pathological Roles of Ro/SSA Autoantibody System

Yoshimi

Ueda

Ozato³

et al. 2012

Clinical and Developmental Immunology

114

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Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

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“…12,14 Because ocular surface epithelial damage could affect visual disturbance and indicates the presence of ocular surface in ammation, the OSS parameter is important for determining treatment for DED patients with pSS. 13,16,31 Previous studies have reported that an association between dry eye and systemic parameters, or extraocular variables. 11,16,32−35 They used the symptoms of ocular dryness, tear osmolarity, or severe DED severity, as indicators of DED.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to our study, few studies used the OSS as the main outcome variable, but only reported correlations with laboratory ndings, such as positive serologic ndings. 15,16 Therefore, we focused on the OSS as the main outcome and analyzed its independent association with systemic parameters, laboratory ndings, oral parameters, and other ocular surface parameters after adjusting other variables.…”

Section: Discussionmentioning

confidence: 99%

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Factors Associated with Ocular Surface Epithelial Damage in Patients with Primary Sjögren's syndrome

Kim

Chin

et al. 2020

Preprint

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Background: The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren's syndrome (pSS).Methods: A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5M were performed, and the Ocular Surface Disease Index was determined. Results: In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 for and β = 0.040, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049).Conclusions: Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.

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Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjögren's syndrome

Abstract: Serum anti-La/SSB antibody, serum anti-Ro/SSA antibody and tear IL-17 are likely to be strongly involved in the clinical severity of KCS in patients with primary SS.

Cited by 36 publications

References 23 publications

Autoantibodies in Sjögren’s Syndrome

Autoantibodies in Sjögren’s Syndrome

Clinical and Pathological Roles of Ro/SSA Autoantibody System

Factors Associated with Ocular Surface Epithelial Damage in Patients with Primary Sjögren's syndrome

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