Prognostic Factors in Adult Granulosa Cell Tumor: A Long Follow-Up at a Single Center

Karalök, Alper; Turan, Taner; Üreyen, Işın; Taşçı, Tolga; Başaran, Derman; Koç, Sevgi; Boran, Nurettin; Köse, Mehmet; Tulunay, Gökhan

doi:10.1097/igc.0000000000000659

Cited by 29 publications

(44 citation statements)

References 27 publications

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“…FIGO stage is the most widely accepted risk factor for recurrence in patients with AGCT, and several studies have shown correlations between higher disease stage and increased recurrence. 4 , 5 The 5-year survival was reported to be 75%–95% in patients with early-stage disease, and this fell to 25%–50% in patients with advanced-stage disease. In the present study, >95% of patients presented with stage I disease, and we therefore analyzed the risk factors for recurrence in stage I disease.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported incidences of retroperitoneal lymph involvement during initial surgery of 0%–12.5%. 6 , 13 A total of eight papers each reported more than 50 cases of AGCT, 1 , 2 , 4 , 6 , 11 , 13 – 15 and the summarized results indicate that the incidence of lymph node metastasis was only 3.9% ( Table 5 ). In accord with previous reports, we found no cases of lymph node metastasis among 52 patients with nodal tissue evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…In accord with previous reports, we found no cases of lymph node metastasis among 52 patients with nodal tissue evaluation. Karalok et al 4 reported the highest rate of lymph node dissection in patients with AGCT to date, and showed that among 121 of 158 (76.6%) patients with systematic lymph node dissection, only three had lymph node metastasis. In addition, lymphadenectomy was not associated with recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological characteristics and prognosis of adult ovarian granulosa cell tumor: a single-institution experience in China

Wang¹,

Xiang²,

Wu³

et al. 2018

OTT

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ObjectivesWe aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China.Patients and methodsWe reviewed 141 patients with AGCT in Peking Union Medical College Hospital between January 1983 and September 2015.ResultsThe mean patient age was 45.1 years (16–78 years), and the mean tumor size was 8.8 cm (1–40 cm). The most common symptom was irregular menstruation (31.9%, n=45). The disease distribution was stage I in 136 patients, stage II in three patients, and stage III in two patients. Eighty-seven patients (61.7%) underwent radical surgery, while 54 (38.3%) underwent fertility-sparing surgery, of whom five subsequently had a total of five pregnancies. Fifty-two patients underwent pelvic and/or paraaortic lymphadenectomy, and none of them showed lymph node metastasis. The median follow-up period was 72.7 months (8.9–344 months). Twenty-six patients (18.4%) developed recurrence during the study period, with a median time to recurrence of 68 months (7–312 months). Initial stage (stage IC vs IA) and nonstaging surgery were independent risk factors for recurrence in both univariate and multivariate analyses for stage I AGCT patients.ConclusionTumor stage is an independent risk factor for recurrence in patients with AGCT. Staging surgery is recommended for patients with AGCT, though lymphadenectomy may be omitted. Complete tumor resection is important for patient survival in patients with AGCT recurrence. Long-term follow-up is required, even in early-stage AGCT patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinicopathological characteristics and prognosis of adult ovarian granulosa cell tumor: a single-institution experience in China

Wang¹,

Xiang²,

Wu³

et al. 2018

OTT

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“…Adult ovarian granulosa cell tumour is a slowly progressive rare ovarian tumour, with a better prognosis when compared to epithelial tumours, though 20-30% of them may recur late. (1,5,22) Ovarian granulosa cell tumour has different clinical behavior and biology compared to epithelial ovarian tumors, with the sustained ability for Estrogen production, which Explains the prevalence of hormone dysfunction related symptoms. In our study Approximately half of the patients presented with either; vaginal bleeding (43%), or Amenorrhea (7%), which may explain the early diagnosis of the disease as 74% were diagnosed in stage I.…”

Section: Discussionmentioning

confidence: 99%

“…However, certain common factors published in the literature had an impact on local failure rate and overall survival, among them; Stage which was shown to be a prognostic factor for survival in many reports. (1,5,27) Five-year overall survival was reported to range between 75-95% in patients with stage I disease and 22-50% in higher stages. (28)(29)(30) Similarly, in the present study, stage was important factor predicting survival with 5-year OS was 100% in stage I disease, whereas it was 64% in stage II -III.…”

Section: Discussionmentioning

confidence: 99%

Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

Badran

Elshenawy

Soudy

et al. 2019

Preprint

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Background: Ovarian granulosa cell tumour is rare. This study aim is to report the clinical characteristics and long-term outcomes of adult-type OGCT (AOGCT) at King Faisal Specialist Hospital and Research Centre ( KFSH&RC) and to determine the prognostic factors affecting relapse and survival. we retrospectively reviewed patients with AOGCT, from 1988 to 2014, who were treated at our institution. Baseline characteristics, pathological findings, and outcomes were analysed, and reported. RESULTS: Sixty-one patients with AOGCT were identified with a median age of 49 years. Median follow-up was 5.0 years (range 2.1 -8.2 years). 74% of patients were FIGO stage I, whereas 7% stage II, 5% stage III and unknown in 14%. The most common presenting symptoms included abdominal pain (43%) and vaginal bleeding (43%). The majority of patients (38 patients, 62%) were treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. Five (8%) patients received adjuvant chemotherapy. Sixteen patients (26%) relapsed with a median time to relapse of 5.5 years (0.7-8.1 years). Half of the recurrences (8 patients, 50%) occurred after 5 years of diagnosis. Five-year overall survival and disease-free survival were 93% and 84%, respectively. Factors associated with high risk of recurrence were presence of ascites (p=0.000) and elevated preoperative CA 125 level (p=0.048). The overall survival was significantly influenced by the menopausal status (premenopausal 100% vs. postmenopausal 84%; p=0.02), preoperative CA 125 (normal 100% vs. elevated 64%; p=0.005), Ascites (present 33% vs. absent 100%; p=0.000), and age (<55 years 100% vs. ≥ 55 years 77%; p= 0.002). CONCLUSION: This study confirms a good outcome of patients with AOGCT. They require long-term follow-up because the recurrence can occur many years post the definitive therapy. The presence of ascites and elevated preoperative CA 125 levels were associated with a higher risk of recurrence and poor prognosis. The outcome seems not to be affected by fertility-sparing surgery and/or adjuvant chemotherapy.

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Identification of prognostic factors and construction of nomogram to predict cancer‐specific survival for patients with ovarian granulosa cell tumors

Zhang,

Ding

et al. 2024

Cancer Reports

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BackgroundOvarian granulosa cell tumors (OGCTs) feature low incidence, indolent growth and late recurrence. Treatment for recurrent OGCTs is challenging.MethodsThe present study was designed to explore the prognostic factors and establish a nomogram to predict cancer‐specific survival (CSS) for OGCTs patients. Enrolled in the study were 1459 eligible patients in the Surveillance, Epidemiology, and End Results (SEER) database, who were randomized to the training (n = 1021) or testing set (n = 438) at a ratio of 7:3. Univariate and multivariate Cox regression analyses were employed to screen the prognostic factors. The predictors were determined by using the Least absolute shrinkage and selection operator (LASSO) regression analysis. The model was constructed via the Cox proportional hazards risk regression analysis. The performance and clinical value of the nomograms was assessed with C‐index, calibration plots, and decision curve analysis.ResultsAge, pTNM stage, tumor size, surgery of the primary tumor, surgery of regional lymph nodes (LNs), residual disease after surgery, and chemotherapy were considered as significant predictive factors for CSS in OGCTs patients. After screening, the prognostic factors except surgery of regional LNs and chemotherapy were employed to build the nomogram. With desirable discrimination and calibration, the nomogram was more powerful in predicting CSS than the American Joint Committee on Cancer staging system in clinical use.ConclusionThis novel prognostic nomogram, which comprises a stationary nomogram and a web‐based calculator, offers convenience for clinicians in personalized decision‐making including optimal treatment plans and prognosis assessments for OGCTs patients.

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Prognostic Factors in Adult Granulosa Cell Tumor: A Long Follow-Up at a Single Center

Cited by 29 publications

References 27 publications

Clinicopathological characteristics and prognosis of adult ovarian granulosa cell tumor: a single-institution experience in China

Clinicopathological characteristics and prognosis of adult ovarian granulosa cell tumor: a single-institution experience in China

Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

Identification of prognostic factors and construction of nomogram to predict cancer‐specific survival for patients with ovarian granulosa cell tumors

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