Prognostic factors in follicular carcinoma of the thyroid: A study of 198 cases

Rao, Renuka; Parikh, Hemen K.; Deshmane, Vinay; Parikh, Deepak M.; Shrikhande, Sumati S.; Havaldar, Rohini

doi:10.1002/(sici)1097-0347(199603/04)18:2<118::aid-hed2>3.0.co;2-4

Cited by 28 publications

(24 citation statements)

References 5 publications

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“…There may be some geographical differences in the behaviour of FTC. In the recent studies from Europe and Asia, the number of patients with lymph-node involvement ranged between 5% and 15% [5,18,21], whereas it was found in 20-25% of the American population [6,11]. However, distant metastases seem to be reported much more frequently for the former groups (20-40%) [5,18,21] than in the extensive studies from the United States (7-12%) [6,11].…”

Section: Follicular Carcinomamentioning

confidence: 93%

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Lymph node dissection in patients with differentiated thyroid carcinoma - who benefits?

Mann

Buhr

1998

Langenbeck's Archives of Surgery

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Section: Follicular Carcinomamentioning

confidence: 93%

“…The incidence of lymph-node metastases in follicular carcinoma (FTC) varies between 5% and 25% [5,6,11,18,21]. There may be some geographical differences in the behaviour of FTC.…”

Section: Follicular Carcinomamentioning

confidence: 99%

Lymph node dissection in patients with differentiated thyroid carcinoma - who benefits?

Mann

Buhr

1998

Langenbeck's Archives of Surgery

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“…This could be a result of fewer patients in most studies, which means that small variations in the variables analyzed can lead to a prognostic factor being significant or not. As a general rule, the following prognostic factors have been reported for this type of carcinoma: age, tumor differentiation, vascular invasion, distant metastasis, nodular affectation, capsular invasion, and tumor extension (13,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37), although, as we have already mentioned, there is a great amount of variability between studies.…”

Section: Discussionmentioning

confidence: 83%

Are prognostic scoring systems of value in patients with follicular thyroid carcinoma?

Rı́os¹,

Rodrı́guez²,

Ferri

et al. 2013

European Journal of Endocrinology

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Purpose: Most prognostic systems for differentiated carcinoma have been designed for papillary carcinoma. Objective: To analyze the value of the existing prognostic systems for evaluating follicular carcinoma and to determine whether any of them have a better predictive effect. Methods: A total of 66 follicular carcinomas were analyzed. The following prognostic systems were studied: EORTC, AGES, AMES, MACIS, TNM, and NTCTCS. Results: The AGES and AMES systems did not demonstrate a good prognostic correlation. In the EORTC system, the rate of disease-free patients was 89% in group 1, 75% in group 2, 69% in group 3, and 0% in group 4. The MACIS system showed 83, 60, 67, and 0% of disease-free patients respectively. The TNM system showed 81, 71, 50, and 0% of disease-free patients respectively. Finally, the NTCTCS system demonstrated 100, 84, 53, and 0% of disease-free patients respectively. Cox's regression analysis was used to calculate the proportion of variation in survival time explained (PVE). The prognostic classification system with the greatest survival prediction was EORTC at 67.64% of PVE, followed by TNM at 62.5% of PVE, and MACIS at 57.82% of PVE. Conclusions: MACIS and TNM are good prognostic systems for evaluating follicular thyroid carcinoma, although the one with the most prognostic value was the EORTC system.

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“…Die Angaben schwanken zwischen 5 und 15 % in Europa und Asien [13,53,61] und 20±25 % in Amerika [18,27,40]. In der NCI-Studie fand sich bei den 2.660 Patienten mit folliculärem Carcinom eine starke Korrelation zwischen Lymphknotenmetastasen und ungünstiger Prognose (5-und 10-Jahres-Überleben: N0 = 100 bzw.…”

Section: Folliculäres Schilddrüsencarcinomunclassified

“…87 %) [18]. Diese Befunde wurden von anderen Autoren bestätigt [53,61]. Die Indikation zur Ausräumung des cervicozentralen Kompartiments im Rahmen des Ersteingriffs läût sich aus denselben Überlegungen wie beim papillären Carcinom ableiten, aber ebenfalls kaum mit Daten belegen.…”

Section: Folliculäres Schilddrüsencarcinomunclassified

Thyreoidektomie und Lymphadenektomie

Buhr

Mann

1999

Chirurg

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In benign goiter, thyroidectomy is only indicated in patients with nodular alterations of the complete thyroid gland. There is no evidence indicating that total thyroidectomy could improve the postoperative results in patients with Graves' disease. In Germany, thyroidectomy with cervicocentral lymph node dissection is the standard procedure for all differentiated thyroid carcinomas. However, there are no data to prove that this approach is superior to less radical procedures. Avoidance of reoperations and optimal conditions for effective postoperative radioiodine therapy are arguments for this aggressive strategy. In patients with medullary carcinoma or with detected ret-proto-oncogene mutations, thyroidectomy with cervicocentral lymphadenectomy should be the initial operation. The cervicolateral and mediastinal compartments should be dissected when clinically obvious lymph node metastases are present in patients with differentiated carcinomas. In patients with medullary carcinomas, persistently increased calcitonin levels after the initial operation are sufficient indication for this procedure. Thyroidectomy is an important part of the multimodal approach in patients with anaplastic carcinomas. The operative technique of thyroidectomy is presented as well as the technique of cervical lymphadenectomy in consideration of the lymphatic drainage of the thyroid gland.

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Prognostic factors in follicular carcinoma of the thyroid: A study of 198 cases

Cited by 28 publications

References 5 publications

Lymph node dissection in patients with differentiated thyroid carcinoma - who benefits?

Lymph node dissection in patients with differentiated thyroid carcinoma - who benefits?

Are prognostic scoring systems of value in patients with follicular thyroid carcinoma?

Thyreoidektomie und Lymphadenektomie

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