Prognostic Factors in Patients With Appendicular Myxofibrosarcoma

Abstract

ObjectiveMyxofibrosarcoma (MFS) is a common soft tissue sarcoma (STS) that affects the extremities in elderly patients. The objective was to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution.MethodsWe retrospectively reviewed the records of 75 patients with MFS. We compared age, sex, tumor size and location, grade and stage of the disease. Median age was 49.7 years (range, 1 to 88 y).Locationupper extremity (25.4%), lower extremity (66.6%) and pelvis (8%). Patients had high-grade tumors in 46.7% of the reports. Margins were negative in 76% of the cases. Bivariate Cox regression analysis was used to determine associations between clinical and treatment factors with local recurrence (LR).ResultsMedian follow-up time was 30.7 months (range, 1.8 to 383.8 m). We found 26.7% of LR. Distant metastasis (DM) was reported in 27 (36%) patients. Lung was the most common site of DM, reported in 92.6% of patients. Overall survival (OS) with metastasis was 21.2 months (range, 4.8 to 114.8 m). Predictors of OS were grade, LR (hazard ratio [HR] 5.13, 95% confidence interval, 2.15-12.24, P <0.001), and DM (HR 540.97, 95% confidence interval, 5.04-58112.03, P< 0.001).ConclusionsTumor grade, LR, positive margins and DM were significant predictors of poor OS prognosis. Level of Evidence IV, Case Series.

A combined, supraclavicular, infraclavicular, transaxillary, and posterior subscapular approaches for en bloc resection of giant myxofibrosarcoma

“…Zumarraga et al examined 75 patients with appendicular MFS and reported that overall survival was correlated with positive surgical margins, local recurrence, and distant metastasis. [16] In their series of 158 patients, Sanfilippo et al found that small tumor size and negative margins were the overall best predictors of survival. [12] Lin et al reported that patients with lower mitotic activity and negative margin status were more likely to have distant metastasis-free survival after MFS resection.…”

“…examined 75 patients with appendicular MFS and reported that overall survival was correlated with positive surgical margins, local recurrence, and distant metastasis. [ 16 ] In their series of 158 patients, Sanfilippo et al . found that small tumor size and negative margins were the overall best predictors of survival.…”

Mesenteric Myxofibrosarcoma: A Case Report

“…Fletcher et al reported that the overall five-year survival rate after surgery for myxofibrosarcoma was 60%-70% [2]. Zumarraga et al reported that any local recurrence increased the potential for distant metastasis, and overall survival was significantly correlated with positive surgical margins, local recurrence, and distant metastasis [13]. Lin et al reported that distant metastasis-free survival after myxofibrosarcoma resection was associated with mitotic activity and margin status [14].…”

Sarcomas de partes moles nos membros, mais comuns e tão graves quanto os sarcomas ósseos

“…A recidiva local não influenciou na sobrevida. Já Zumárraga et al 33 relataram que nos pacientes com mixofibrossarcoma um pior prognóstico da sobrevida global estava relacionado com o grau histológico do tumor, margens comprometidas, recidiva local e metástases à distância. Wu et al 34 relatam que nos lipossarcomas mixóides a idade (> 30 anos), sexo masculino, grau do tumor (alto grau) e tamanho do tumor (> 10 cm) eram fatores prognósticos independentes para sobrevida global e na doença específica em pacientes com SPM das extremidades.…”