Prognostic factors of neck node metastasis

Snow, Gordon B.; Annyas, A. A.; Slooten, E. A. van; Bartelink, H.; Hart, A. A. M.

doi:10.1111/j.1365-2273.1982.tb01581.x

Cited by 437 publications

(210 citation statements)

References 10 publications

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“…[1][2][3][4] However, the current study is the first study of patients with SCCOT to compare clinical outcomes with respect to clinical and pathologic lymph node stages. Statistically significant differences in survival were found for both cN0 -N2 and pN0 -pN2 stages, although the differences in pathologic staging reached a higher level of statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…This finding has also been recognized in previous large reviews of patients with SCCHN who underwent neck dissection. 4,[47][48][49][50] The presence of ECS is another poor prognosticator. [5][6][7][8][9][10][11][12] ECS may be detected radiographically, 51 but neck dissection remains the only definitive method to identify the presence of ECS.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Survival decreases by 50% with the presence of regional lymphadenopathy. 1 Myers et al 5 demonstrated significantly worse survival rates and higher recurrence rates in SCCOT patients with advanced lymph node disease.…”

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confidence: 99%

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Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

Greenberg

Naggar

et al. 2003

Cancer

167

116

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At present, storage capacities of single tank and tank farm have been greatly increasing. This change poses a real challenge for the applicability of current design standards. This article focuses on the applicability of safety spacing between tanks, which is one of the most important parameters of tank farm safety design. Taking PHAST and FDS as main research tools, the consequences of representative accidental scenarios were evaluated for different sizes of oil tanks to study the safety performance change caused by the increase of capability. The research results show that, when current standards are used to design the safety spacing between tanks, the safety performance increases as the capability increases. Considering the high property density, it is suggested that a higher safety performance objective has to be chosen when designing the safety spacing for ultra‐large oil tanks. © 2012 American Institute of Chemical Engineers Process Saf Prog, 2012.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

Greenberg

Naggar

et al. 2003

Cancer

167

116

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“…Identification of those who are at greatest risk for developing distant metastasis and mortality from prostate cancer will help stratify patients into prognostically distinct groups. Previous studies demonstrated that assessment of extranodal extension (ENE) in patients who are node positive may provide prognostic information in certain human epithelial malignancies, including breast cancer (10,11), squamous cell carcinoma of the vulva (12,13), gastric carcinoma (14), and squamous carcinoma of the head and neck (15)(16)(17)(18)(19)(20)(21). Others refuted the significance of ENE (22)(23)(24)(25)(26).…”

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confidence: 99%

Extranodal Extension in Lymph Node–Positive Prostate Cancer

et al. 2000

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Evaluation of extranodal tumor extension may provide prognostic information for patients with epithelial malignancies. However, its importance for the patient who has prostate cancer with regional lymph node metastasis requires further investigation and clarification. This study was performed to evaluate the prognostic significance of extranodal extension (ENE) in a large series of node-positive patients. The study group included 212 nodepositive patients who were treated by bilateral pelvic lymphadenectomy, radical retropubic prostatectomy, and androgen deprivation between 1987 and 1992 at the Mayo Clinic. ENE was defined as cancer perforating through the lymph node capsule into perinodal tissue. Nodal cancer volume was measured by the grid method. Univariate and multivariate risk ratios (RR) for distant metastasis-free and cancer-specific survival were estimated using the Cox proportional model. The mean follow-up was 6.3 years (median, 6.1 years). Distant metastasisfree and cancer-specific survival at 5 years for all patients was 91% and 95%, respectively. ENE was found in 126 of 212 patients (59%). The presence of ENE was not significantly associated with distant metastasis-free (RR ‫؍‬ 1.6; 95% confidence interval [CI], 0.7 to 3.9) or cancer-specific survival (RR ‫؍‬ 2.2; 95% CI, 0.7 to 6.8). Among 98 patients with a single positive node, there was no significant difference in distant metastasis or cancer-specific survival according to the presence of ENE (P ‫؍‬ .88 and P ‫؍‬ .36, respectively). After adjusting for Gleason score, DNA ploidy, and ENE, only nodal cancer volume was significantly associated with adverse distant metastasis-free (RR ‫؍‬ 1.9; 95% CI, 1.5 to 2.8) and cancer-specific survival (RR ‫؍‬ 1.4; 95% CI, 1.1 to 1.9). Our data indicate that the presence of ENE is not associated with unfavorable survival in patients with node-positive prostate cancer treated by radical retropubic prostatectomy, bilateral pelvic lymphadenectomy, and androgen deprivation therapy. In contrast, nodal cancer volume was predictive of distant metastasis-free survival and cancerspecific survival.

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“…But study carried out by G.B Snow and his team showed enlarged lymph node <3 cm in 85% and > 3 cm in size in 15% only. 13 …”

Section: Introductionmentioning

confidence: 99%

Metastatic neck node with unknown primary

Karim

Siddiquee

Masud

et al. 2014

Bangladesh J of Otorhinolaryngology

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Objective: To find out the clinical presentation of metastatic neck node with unknown primary. Methods:A cross-sectional study done on the admitted patient from four tertiary level hospitals in Dhaka city from January 2010 to September 2010. Results: Most of the cases were squamous cell carcinoma (68.75%). the next common was adenocarcinoma (15.62%) and undifferentiated carcinoma (12.5%). Melanoma was a rare condition (3.13%). The commonest age group was 6 th decade (40.63%) which was followed by 5 th decade (28%). None of the case was found bellow the age of 30 years. The male to female ratio was 2:1. Commonest metastatic group of lymph node was Level II (50%), followed by Level-III (22%) Level-IV (19%), Level-V (6%) and Level-I (3%). Staging of lymph nodes were

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Prognostic factors of neck node metastasis

Cited by 437 publications

References 10 publications

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma

Extranodal Extension in Lymph Node–Positive Prostate Cancer

Metastatic neck node with unknown primary

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