Prognostic factors of patients with mycosis fungoides

Bahalı, Anıl Gülsel; Su, Özlem; Cengiz, Fatma Pelin; Emiroğlu, Nazan; Özkaya, Dilek Bıyık; Onsun, Nahide

doi:10.5114/ada.2020.100491

Cited by 19 publications

(10 citation statements)

References 17 publications

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“…In the study, there was no statistically significant correlation between the number of eosinophils and the stage of the disease, nor between the number of cells and the treatment response [147]. Other authors did not find significant correlations between the number of infiltrating eosinophils and the disease stage in MF [148]. However, many studies proposed an active role for eosinophils within the infiltrate in CTCL [149,150].…”

Section: Eosinophils' Role In Mf and Ssmentioning

confidence: 70%

The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

Pileri

Guglielmo

Grandi

et al. 2021

Cells

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Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.

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Section: Eosinophils' Role In Mf and Ssmentioning

confidence: 70%

The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

Pileri

Guglielmo

Grandi

et al. 2021

Cells

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“…The increased total IgE measured in our patient occurs mainly in the advanced stage of the disease. It is also discussed in the literature as a prognostic marker for further progression in primary cutaneous T-cell lymphomas such as mycosis fungoides [5]. A possible explanation for the elevated IgE levels in lymphomas is the increased release of Th2 cytokines such as interleukin-4 [6].…”

Section: Discussionmentioning

confidence: 99%

Persistent facial swelling

Mengoni

Lenz

Braun

et al. 2022

J Deutsche Derma Gesell

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We report on an 84-year-old female patient who presented to the emergency service of our clinic owing to marked swelling of the face (Figure 1). The complaints had first appeared five months earlier. Suspecting angioedema, systemic steroids (prednisolone up to a maximum of 250 mg/d) and antihistamines (cetirizine 40 mg/d) were repeatedly administered by the general practitioner. Under this therapy, however, there was only short-term improvement of the symptoms. At no time were there wheals, a globus sensation or dyspnea, nor were there gastrointestinal or cardiovascular symptoms. Known underlying diseases were diabetes mellitus type 2, hypothyroidism and arterial hypertension. Physical exami-nation revealed asymmetric indolent swelling of the face with diffuse erythema and telangiectasia. The cervical lymph nodes were bilaterally palpably enlarged.

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“…16 Additionally, higher levels of β2microglobulin, lactate dehydrogenase, and total IgE are associated with a more advanced disease stage. 20 Scarisbrick (University Hospital Birmingham and the University of Birmingham, UK) reported the results of an analysis of the PROspective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study, which aimed to identify prognostic factors in MF and SS (n=698). 21 In early-stage CTCL, the presence of plaques and large cell transformation (LCT) in the skin were associated with disease progression.…”

Section: Julia Scarisbrick and Vanessa Gargallo Monevamentioning

confidence: 99%

An Overview of the EORTC-CLTG 2022 Congress

Humphry¹

2022

EMJ Oncol

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This year's European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Tumours Group (CLTG) Annual Meeting was held in Madrid, Spain. Presentations covered a broad range of topics in the field of cutaneous lymphomas, from molecular mechanisms, through diagnostics and prediction of prognosis, to skin-directed and targeted therapies, combination therapies, and patient-reported outcomes.There was an overall feeling at the EORTC-CLTG meeting that further research is needed to better define the molecular basis for the different forms of cutaneous T cell lymphoma (CTCL), which will facilitate the development of novel treatments and therapeutic drug combinations. However, it was clear that significant progress had been made in understanding the biology behind CTCL, and that a broad range of therapies are available that provide symptomatic control in many patients.

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Prognostic factors of patients with mycosis fungoides

Cited by 19 publications

References 17 publications

The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

Persistent facial swelling

An Overview of the EORTC-CLTG 2022 Congress

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