Prognostic factors of pelvic MRI at the initial workflow in locally advanced rectal cancer: Focus on extra mural venous invasion and tumour deposits

Mayaud, Alexandre; Bousarsar, Amal; Soltani, Saïd; Sotton, Sandrine; Grange, Rémi; Roy, Bertrand Le; Phélip, Jean-Marc; Billen, Claire; Magné, Nicolas

doi:10.1016/j.bulcan.2022.03.003

Cited by 1 publication

(2 citation statements)

References 29 publications

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“…However, recent studies have shown that there are other prognostic factors for predicting 2yDFS, such as tumoral deposits, EMVI, MRF involvement and positive nodes [ 14 , 45 , 46 ], that are located in the mesorectum.…”

Section: Discussionmentioning

confidence: 99%

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Delta Radiomic Analysis of Mesorectum to Predict Treatment Response and Prognosis in Locally Advanced Rectal Cancer

Chiloiro

Cusumano

Romano

et al. 2023

Cancers

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Background: The aim of this study is to evaluate the delta radiomics approach based on mesorectal radiomic features to develop a model for predicting pathological complete response (pCR) and 2-year disease-free survival (2yDFS) in locally advanced rectal cancer (LARC) patients undergoing neoadjuvant chemoradiotherapy (nCRT). Methods: Pre- and post-nCRT MRIs of LARC patients treated at a single institution from May 2008 to November 2016 were retrospectively collected. Radiomic features were extracted from the GTV and mesorectum. The Wilcoxon–Mann–Whitney test and area under the receiver operating characteristic curve (AUC) were used to evaluate the performance of the features in predicting pCR and 2yDFS. Results: Out of 203 LARC patients, a total of 565 variables were evaluated. The best performing pCR prediction model was based on two GTV features with an AUC of 0.80 in the training set and 0.69 in the validation set. The best performing 2yDFS prediction model was based on one GTV and two mesorectal features with an AUC of 0.79 in the training set and 0.70 in the validation set. Conclusions: The results of this study suggest a possible role for delta radiomics based on mesorectal features in the prediction of 2yDFS in patients with LARC.

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Section: Discussionmentioning

confidence: 99%

“…Recently, several factors have been proposed to identify more aggressive biological tumour behaviour. These include extramural vascular invasion (EMVI), involvement of the mesorectal fascia (MRF), the presence of pathological extra-mesorectal lymph nodes and tumour deposits [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%