Prognostic factors of quality of life after transoral laser microsurgery for laryngeal cancer

Abstract

We aimed to evaluate factors influencing quality of life (QOL) after transoral laser microsurgery (TLM) of laryngeal cancer. Four hundred and one consecutive disease-free patients were evaluated 1 year after treatment using the University of Washington-QOL v4, the SF-12 (short form of SF-36), and a questionnaire about self-rated health status. The importance of age, gender, tumor location, tumor size, tumor stage, neck dissection and adjuvant treatment were evaluated. One year after TLM patients had a good QOL, with only 6 % of patients reporting a worsening in their health status. Radiation therapy (p = 0.000) and neck dissection (p = 0.000) were negative factors for disease-specific QOL, whereas age ≥ 70 (p = 0.01) was a positive independent factor for mental score of SF-12. Speech was negatively influenced by tumor size (p = 0.001) as was swallowing by age (p = 0.001) and postoperative radiation (p = 0.000). Patients treated with TLM present a good QOL 1 year after surgery. Radiation and neck dissection negatively impact QOL. Elderly patients cope better with their disabilities.

Transoral laser microsurgery for locally advanced (T3-T4a) supraglottic squamous cell carcinoma: Sixteen years of experience

“…On one side, neck status is recognized as the most important independent factor for survival . On the other side, neck dissection adds morbidity to the process and has been reported as an independent factor of quality of life after TLM . Classically, prophylactic neck dissection was recommended for potential occult metastasis above 20% .…”

Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision‐tree analysis

“…2 However, other authors have expressed contrary opinions. 38 Moreover, paraglottic infiltration was the most important factor of reduced LC-TLM according to CHAID decision tree, and only 56.8% of the patients could be cured with laser alone. In our series, half of the patients with AC involvement that recurred locally, were finally salvaged with TLM, suggesting that surgical experience could have played a role in the outcome.…”

Long-term quality of life after transoral laser microsurgery for laryngeal carcinoma

“…In previous studies, we reported good QOL 1 year after TLM in both early and advanced laryngeal tumors . The purpose of the present study was to assess long‐term QOL among disease‐free patients treated with TLM for laryngeal cancer, using the Spanish‐validated versions of the UW‐QOL v4, the SF‐12 v2, and the VHI‐10.…”