2023
DOI: 10.1002/cpt.2977
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Prognostic Factors of COVID‐19: An Umbrella Review Endorsed by the International Society for Pharmacoepidemiology

Abstract: During the coronavirus disease 2019 (COVID‐19) pandemic, the urgency for updated evidence to inform public health and clinical care placed systematic literature reviews (SLRs) at the cornerstone of research. We aimed to summarize evidence on prognostic factors for COVID‐19 outcomes through published SLRs and to critically assess quality elements in the findings' interpretation. An umbrella review was conducted via electronic databases from January 2020 to April 2022. All SLRs (and meta‐analyses) in English wer… Show more

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Cited by 5 publications
(2 citation statements)
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“…Given the complexity of the condition, a diverse range of potential predictors warrant consideration. Older age, female sex, pre-existing conditions (e.g., high BMI, asthma, and diabetes), and severity of acute illness, have frequently been proposed as risk factors for postacute sequelae [3,4,15,[18][19][20]. Additionally, a number of biomarkers have been investigated but currently, there is no consensus as to whether any characterize PCC [14,16,17].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Given the complexity of the condition, a diverse range of potential predictors warrant consideration. Older age, female sex, pre-existing conditions (e.g., high BMI, asthma, and diabetes), and severity of acute illness, have frequently been proposed as risk factors for postacute sequelae [3,4,15,[18][19][20]. Additionally, a number of biomarkers have been investigated but currently, there is no consensus as to whether any characterize PCC [14,16,17].…”
Section: Discussionmentioning
confidence: 99%
“…The etiology of PCC remains uncertain, though several underlying pathophysiological mechanisms, such as cellular damage, inflammatory cytokines, and a hypercoagulable state, are thought to contribute to PCC inception and trajectory [7,[14][15][16][17].Given the complexity of the condition, a diverse range of potential predictors warrant consideration. Older age, female sex, pre-existing conditions (e.g., high BMI, asthma, and diabetes), and severity of acute illness, have frequently been proposed as risk factors for postacute sequelae [3,4,15,[18][19][20]. Additionally, a number of biomarkers have been investigated but currently, there is no consensus as to whether any characterize PCC [14,16,17].Investigation of potential serological markers of PCC, accounting for clinical covariates, may yield pathophysiological insights.…”
mentioning
confidence: 99%