Prognostic factors related to mortality in newborns with necrotising enterocolitis

Bracho-Blanchet, Eduardo; Torrecilla-Navarrete, María Esther; Zalles-Vidal, Cristian; Ibarra-Ríos, Daniel; Fernandez-Portilla, Emilio; Dávila-Pérez, Roberto

doi:10.1016/j.circen.2015.09.015

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…10,17,19 There have been reported studies about the delayed diagnosis of congenital anomalies such as anorectal malformations and jejunoileal atresia, but this is the first study that mentions the delay in diagnosis of OA. [20][21][22] The major limitation with this paper, is whether the patient population studied is sufficiently 'representative' for developed countries. Although delayed diagnosis in OA is a rare and inexcusable condition in developed countries, the situation in developing countries is entirely different and our new classification may be more relevent to these populations.…”

Section: Discussionmentioning

confidence: 98%

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Delayed diagnosis: An important prognostic factor for oesophageal atresia in developing countries

Karakuş

Özokutan

Bakal

et al. 2016

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 98%

“…There have been reported studies about the delayed diagnosis of congenital anomalies such as anorectal malformations and jejunoileal atresia, but this is the first study that mentions the delay in diagnosis of OA …”

Section: Discussionmentioning

confidence: 99%

Delayed diagnosis: An important prognostic factor for oesophageal atresia in developing countries

Karakuş

Özokutan

Bakal

et al. 2016

J Paediatrics Child Health

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“…We evaluated the following prognostic factors for the survival of neonates with NEC: sex, birth weight, NEC staging, platelet count, APGAR score, and type of treatment. Birth weight was classified into extremely low birth weight (<1,000 g), very low birth weight (<1,500 g), low birth weight (<2,500 g), and normal (≥2,500 g) according to World Health Organization classification, while the platelet count was defined as thrombocytosis (>350,000/mm 3 ), normal (≥150,000–350,000/mm 3 ), and thrombocytopenia (<150,000/mm 3 ) according to a previous study ( 6 ). The type of treatment is divided into conservative and surgical procedures, while the APGAR Score was classified as asphyxia (<8) and non-asphyxia (≥8).…”

Section: Methodsmentioning

confidence: 99%

“…Due to the continually improving survival of preterm neonates, the modifiable prognostic factors of NEC are essential to be investigated and considered in making a suitable treatment to decrease the prevalence and effect of NEC ( 4 ). Many prognostic factors have been associated with the survival of neonates with NEC; however, the studies show conflicting results ( 1 , 5 , 6 ). Moreover, the study from developing countries regarding NEC outcomes is minimal ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Outcomes and Prognostic Factors for Survival of Neonates With Necrotizing Enterocolitis

et al. 2021

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Background: Due to the survival of preterm neonates being continually improved, the modifiable prognostic factors of necrotizing enterocolitis (NEC) are essential to be investigated and considered in making a suitable treatment to decrease the prevalence and effect of NEC. Many prognostic factors have been associated with the survival of neonates with NEC; however, the studies show conflicting results. Moreover, the study from developing countries regarding NEC outcomes is minimal. Here, we aimed to determine the survival of neonates with NEC and associate it with the prognostic factors.Methods: A retrospective study was conducted using medical records of neonates with NEC at our institution from January 2014 to December 2019.Results: Fifty-two neonates with NEC were involved with the overall survival of 44.2%. Log-rank analysis showed that NEC staging and birth weight were significantly associated with the survival of neonates with NEC with a p-value of 0.010 and 0.002, respectively, while sex, APGAR score, platelet count, and type of treatment were not (p = 0.068, 0.752, 0.087, and 0.343, respectively). Multivariate analysis revealed that sex and NEC staging were strongly associated with the survival of neonates with NEC with a p-value of 0.018 [HR = 3.10 (95% CI = 1.21–7.93)] and 0.019 [HR = 0.44 (0.22–0.87)], respectively.Conclusions: Our study shows that sex and NEC staging might affect the survival of neonates with NEC. It implies that NEC staging should be closely monitored and intervened as early as necessary to prevent further morbidity and mortality.

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“…Тип атрезии в данном случае не являлся предиктором неблагоприятного исхода. Авторы заключили, что основным аспектом снижения смертности может быть только своевременная диагностика атрезии [62].…”

Section: способы и методики хирургического лечения атрезии тонкой кишкиunclassified

Surgical treatment of newborns with small bowel atresia (literature review)

Batchenko¹,

Mokrushina²,

Gogichaeva³

2020

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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Intestinal atresia is a congenital obstruction of the lumen of the jejunum or ileum and is one of the most common causes of congenital obstruction in newborns. This literature review is devoted to the surgical treatment of newborns with various types intestinal atresia. Causes of intestinal atresia are considered, where a special role is assigned to the genetic theory, the expression of the nucleotide sequences ITGA2 873G/A and NPPA 2238T/C and antenatal circulatory disorders of the developing intestine. Topographical-anatomical and morphological characteristics of the intestine in newborns with intestinal atresia are studied in detail in articles. A table of revealed histomorphological features of the small intestine in children with atresia was compiled. In addition, processes occurring in the mucosa, submucosa, muscle, and serous membranes are described in detail. A relationship was found related to the size of the atresia site and duration of ischemia. The theory of neuromuscular regulation of the intestine is considered, in which an important role is assigned to interstitial pacemaker cells of Cajal. Variants of anastomosis depending on the difference in diameters of the adductor and excretory parts of the intestine are analyzed, and results of treatment in patients with laparoscopic access are described. The postoperative course of disease, development of complications, recurrent operative interventions, duration of parenteral nutrition, and onset of enteral load was evaluated. Conclusion. The choice of surgical technologies used to restore the patency of the intestinal tube is determined by the degree of discrepancy between diameters of anastomosed segments. The prognosis is not determined by tactics of surgical treatment, type of atresia, time before treatment, and presence of associated anomalies.

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Prognostic factors related to mortality in newborns with necrotising enterocolitis

Cited by 8 publications

References 15 publications

Delayed diagnosis: An important prognostic factor for oesophageal atresia in developing countries

Delayed diagnosis: An important prognostic factor for oesophageal atresia in developing countries

Outcomes and Prognostic Factors for Survival of Neonates With Necrotizing Enterocolitis

Surgical treatment of newborns with small bowel atresia (literature review)

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