Prognostic impact of atrial fibrillation progression in a community study: AFBAR Study (Atrial Fibrillation in the Barbanza Area Study)

New-generation atrial antitachycardia pacing (Reactive ATP) is associated with reduced risk of persistent or permanent atrial fibrillation in patients with bradycardia: Results from the MINERVA randomized multicenter international trial

“…These results have clinical importance because evolution toward permanent AF is an important prognostic marker for death, stroke, or hospital admissions in primary care. [16][17][18] The Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial 16 evaluated 18,201 patients with AF and found that the risk of stroke or systemic embolism was significantly higher in patients with persistent or permanent AF than in those with paroxysmal AF. The Atrial Fibrillation in the Barbanza Area Study 17,18 identified progression to permanent AF as a predictor of mortality or hospitalizations in an unselected population with AF.…”

“…The new results reported here of the MINERVA trial for the first time convincingly indicate that Reactive ATP is an effective means of preventing AF disease progression. Reducing the risk of persistent and permanent AF have clinical and economic relevance in terms of improved patient care, by lowering the risk of stroke and heart failure, [16][17][18][19][20] and of reduced health care resources and costs. 15,21 Indeed, the importance of new therapies for AF is confirmed by the fact that AF accounts for approximately one-third of hospitalizations for cardiac rhythm disturbances and is displaying a clear upward trend worldwide.…”

Cost Effectiveness of Radiofrequency Catheter Ablation vs. Medical Treatment for Atrial Fibrillation in Japan - Cost Performance for Atrial Fibrillation -

“…A study conducted in Europe reported an overall mortality rate at 7 months of 2.6% (4.5% yearly) and rates of 0.8% (1.4% yearly) for cerebral embolism and 2.9% (5.0% yearly) for heart failure. 12 Although the rate of cerebral embolism is almost identical (≈1.5% yearly) between Japanese and European patients, the rates of heart failure and mortality are thought to increase according to the duration of AF as well as age. These substantial differences in results may be related to differences in the target population, including the rate of AF, and therefore the epidemiology of complications of AF is considered extremely difficult to elucidate.…”

Modulation of Autonomic Nervous Activity in the Termination of Paroxysmal Atrial Fibrillation

“…Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia requiring medical care . Autonomic nervous activity plays a critical role in the genesis, maintenance, and termination of paroxysmal AF (PAF) .…”

“…Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia requiring medical care. 1,2 Autonomic nervous activity plays a critical role in the genesis, maintenance, and termination of paroxysmal AF (PAF). [3][4][5] Enhanced adrenergic activity with increased atrial or pulmonary vein (PV) arrhythmogenesis is common in the initiation of PAF, 6,7 and increased vagal activity facilitates the occurrences of AF at night due to a shortening of atrial refractoriness caused by activation of an acetylcholine-sensitive potassium current.…”