Prognostic Impact of pT3 Subclassification in a Multicentre Cohort of Patients with Urothelial Carcinoma of the Renal Pelvicalyceal System Undergoing Radical Nephroureterectomy: A Propensity Score-weighted Analysis After Central Pathology Review

Seisen, Thomas; Mari, Andrea; Campi, Riccardo; Peyronnet, B.; Bensalah, Karim; Rioux‐Leclercq, Nathalie; Pfister, Christian; Gobet, Françoise; Taille, Alexandre de la; Allory, Yves; Xylinas, Évanguelos; Radulescu, C.; Descotes, Jean‐Luc; Saada-Sebag, G.; Irani, Jacques; Delpech-Debiais, Céline; Bigot, Pierre; Eymerit, Caroline; Crouzet, Sébastien; Mège‐Lechevallier, Florence; Ruffion, A.; Decaussin‐Petrucci, Myriam; Droupy, S.; Roger, Pascal; Durand, Xavier; Camparo, Philippe; Cussenot, Olivier; Compérat, Éva; Rouprêt, Morgan

doi:10.1016/j.euf.2020.10.004

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…Both factors were the most frequent comorbidities and concerned more than 12% of patients included. This percentage is likely underestimated, as for other comorbidities, due to PMSI data availability limitations [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Population characteristics, management, and survival outcomes in muscle-invasive urothelial carcinoma undergoing radical resection: the MINOTAUR study

Rouprêt

Brouquet²,

Colrat

et al. 2023

World J Urol

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Purpose To describe the incidence, management, and survival outcomes of patients with muscle-invasive urothelial carcinoma (MIUC) undergoing radical surgery (RS) in France. Methods We relied on a non-interventional real-world retrospective study based on French National Hospitalization Database. Adults with MIUC with a first RS between 2015 and 2020 were selected. Subpopulations of patients with RS performed in 2015 and 2019 (pre-COVID-19) were extracted, according to cancer site: muscle-invasive bladder cancer (MIBC) or upper tract urothelial carcinoma (UTUC). Disease-free and overall survival (DFS, OS – Kaplan–Meier) were assessed on the 2015 subpopulation. Results Between 2015 and 2020, 21,295 MIUC patients underwent a first RS. Of them, 68.9% had MIBC, 28.9% UTUC, and 2.2% both cancers. Apart from fewer men among UTUC (70.2%) than MIBC patients (90.1%), patients’ demographic (mean age ~ 73 years) and clinical characteristics were similar whatever the cancer site or year of first RS. In 2019, RS alone was the most frequent treatment, occurring in 72.3% and 92.6% in MIBC and UTUC, respectively. Between 2015 and 2019, neoadjuvant use rate increased from 13.8% to 22.2% in MIBC, and adjuvant use rate increased from 3.7% to 6.3% in UTUC. Finally, median [95% confidence interval] DFS times were 16.0 [14.0–18.0] and 27.0 [23.0–32.0] months among MIBC and UTUC, respectively. Conclusion Among patients with resected MIUC annually, RS alone remained the main treatment. Neoadjuvant and adjuvant use increased between 2015 and 2019. Nonetheless, MIUC remains of poor prognosis, highlighting an unmet medical need, notably among patients at high risk of recurrence.

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Section: Discussionmentioning

confidence: 99%

Population characteristics, management, and survival outcomes in muscle-invasive urothelial carcinoma undergoing radical resection: the MINOTAUR study

Rouprêt

Brouquet²,

Colrat

et al. 2023

World J Urol

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“…Identifying prognostic factors specific to UTUC may help us better understand the prognostic differences between UTUC and BC. In this study, we focused on renal parenchymal invasion (RPI), which is considered to be a poor prognostic factor for localized renal pelvis cancer 8 as a prognosticator. We also retrospectively compared the prognoses of UTUC and BC to investigate the impact of RPI.…”

Section: Introductionmentioning

confidence: 99%

The poor antitumor effect of pembrolizumab in advanced upper urothelial carcinoma with renal parenchymal invasion

et al. 2023

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ObjectivesWe investigated poor prognosticators in advanced or unresectable urothelial carcinoma, focusing on renal parenchymal invasion (RPI).MethodsThis study included 48 bladder cancer (BC) and 67 upper tract urothelial carcinoma (UTUC) patients treated with pembrolizumab from December 2017 to September 2022 at Kobe University Hospital. Medical records were retrospectively reviewed for clinical characteristics, objective response rate (ORR), progression‐free survival (PFS), and overall survival (OS). Multivariate analyses were performed using the Cox proportional hazard regression model to identify parameters associated with either PFS or OS.ResultsOf 67 UTUC patients, 23 had RPI and 41 patients did not, while 3 cases could not be evaluated. Patients with RPI were predominantly elderly and had liver metastases. ORR for patients with RPI was 8.7%, while it was 19.5% for those without RPI. PFS was significantly shorter for patients with RPI compared with those without RPI. Patients with RPI had significantly shorter OS than those without RPI. On multivariate analysis, performance status (PS) ≥ 2, neutrophil‐lymphocyte ratio (NLR) ≥ 3, C‐reactive protein ≥0.3 mg/dL and RPI were independent prognostic factors for PFS. PS ≥ 2, NLR ≥ 3, visceral metastasis and RPI were independent prognostic factors for OS. UTUC patient OS was significantly shorter than BC patient OS, while no significant difference in PFS or OS was observed between BC patients and UTUC patients without RPI.ConclusionsRPI was a poor prognostic factor in advanced urothelial carcinoma treated with pembrolizumab, possibly resulting in a poorer prognosis for UTUC compared with BC.

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Subclassification of pT3 upper tract urothelial carcinoma: a multicenter retrospective study

Yamada

Nakagawa²,

Miyakawa³

et al. 2023

World J Urol

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Prognostic Impact of pT3 Subclassification in a Multicentre Cohort of Patients with Urothelial Carcinoma of the Renal Pelvicalyceal System Undergoing Radical Nephroureterectomy: A Propensity Score-weighted Analysis After Central Pathology Review

Cited by 6 publications

References 32 publications

Population characteristics, management, and survival outcomes in muscle-invasive urothelial carcinoma undergoing radical resection: the MINOTAUR study

Population characteristics, management, and survival outcomes in muscle-invasive urothelial carcinoma undergoing radical resection: the MINOTAUR study

The poor antitumor effect of pembrolizumab in advanced upper urothelial carcinoma with renal parenchymal invasion

Subclassification of pT3 upper tract urothelial carcinoma: a multicenter retrospective study

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