Prognostic impact of the level of nodal involvement: retrospective analysis of patients with advanced oral squamous cell carcinoma

Murakami, Ryuji; Nakayama, Hideki; Semba, Akiko; Hiraki, Akimitsu; Nagata, Masashi; Kawahara, Katsunobu; Shiraishi, Shinya; Hirai, Toshinori; Uozumi, Hideaki; Yamashita, Yasuyuki

doi:10.1016/j.bjoms.2016.08.026

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…97 Similar findings have been demonstrated by several others. [98][99][100][101] In another interesting study, the impact of the involvement of facial lymph node on survival was assessed. Of 641 OSCC patients, 103 presented with metastasis to facial lymph nodes and were strongly associated with poor disease control and lower survival rates.…”

Section: Cellular Cannibalismmentioning

confidence: 99%

Clinico-pathological prognosticators in oral squamous cell carcinoma

Majumdar¹,

Patil

Sarode

et al. 2017

Translational Research in Oral Oncology

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Despite diagnostic and therapeutic advancements, mortality and morbidity rates in the patients diagnosed with oral cancer remain static. Hence, an understanding of the factors that predict the progression of oral cancer appears to be useful in deciding on the most appropriate therapy, thereby improving survival. To do so in practice, a critical knowledge of prognostic markers that have high sensitivity is essential. Though recent research has introduced newer molecular markers, challenging the conventional prognostic assessment methods their universal application is yet to be determined. In practice, clinical and histopathological parameters are widely used for the selection of treatment strategies and for the determination of prognosis in oral cancer patients. A literature search yielded a multitude of parameters to be involved in the determination of prognosis of a patient. Based on published evidence, factors of significance were pTNM, tumour volume, depth of invasion, surgical margin status, tumour budding, vascular and perineural invasion, medullary bone invasion, extracapsular spread and the presence of distant metastasis.

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Section: Cellular Cannibalismmentioning

confidence: 99%

Clinico-pathological prognosticators in oral squamous cell carcinoma

Majumdar¹,

Patil

Sarode

et al. 2017

Translational Research in Oral Oncology

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“…Our results are consistent with these findings. However, Murakami et al reported a lower incidence of lymph node metastasis in OSCC patients: 2.9% for level IV and 1.0% for level V . However, these findings may have been affected by the fact that the patients received preoperative CRT.…”

Section: Discussionmentioning

confidence: 98%

Multicenter retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with level IV/V metastasis

et al. 2019

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Background: The purpose of this study was to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma and level IV/V metastasis and to compare patients who underwent no postoperative therapy with those who underwent postoperative radiotherapy (RT) and concomitant chemoradiotherapy (CCRT). Methods: We evaluated 669 patients. Clinicopathological data, postoperative therapy, and clinical course were investigated. Results: Sixty-one patients (9.1%) developed level IV/V metastasis. The 3-year cumulative overall survival rates of patients with and without level IV/V metastasis were 47.3% and 64.3%, respectively. Tongue tumors, pN2 or N3 classification, and moderate or poor differentiation were significantly associated with the development of level IV/V metastasis. The surgery+RT/CCRT group was associated with better 3-year cumulative disease-specific survival and overall survival rates than the surgery only group. Conclusion: Adjuvant therapy (RT alone or CCRT) after surgery is recommended for patients with level IV/V metastasis. K E Y W O R D Slevel IV/V metastasis, lymph node metastasis, neck level, oral cancer, risk factor

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“…Such patients undergo only adjuvant radiation therapy [7,14]. Despite the fact that the statistically significant negative effects of intermediate risk factors have been confirmed in many studies, only the positive resection margins and extracapsular nodal tumor extension remain independent factors [8,9,[14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma

et al. 2023

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Summary. The aim of the work was to study clinical and pathological factors affecting the prognosis of the disease in patients with stage III–IVA-B oral squamous cell carcinoma (OSCC). Materials and Methods: A retrospective review of medical records of 234 patients with stage III–IVA-B OSCC was performed in order to study the impact of clinical and pathological factors on disease-free survival (DFS) and overall survival (OS). Results: Multivariable analysis of clinical factors revealed a statistically significant effect of stage IVA-B and the presence of surgical complications on DFS (hazard ratio (HR) = 4.9 (95% confidence interval (CI) 2.9–8.3), p < 0.001; HR = 1.6 (95% CI 1.0–2.6), p = 0.047), respectively. Stage IVA-B, the presence of surgical complications and the retromolar trigone subsite were found to have a statistically significant impact on OS (HR = 4.0 (95% CI 2.5–6.5), p < 0.001; HR = 1.8 (95% CI 1.1–2.8), p = 0.01; HR = 1.9 (95% CI 1.1–3.2), p = 0.02), respectively. Multivariable analysis of pathological factors showed a statistically significant effect of positive resection margins, the multiple lymph node involvement and high-grade tumor on DFS (HR = 3.7 (95% CI 2.0–6.6), p < 0.001; HR = 4.3 (95% CI 2.8–6.7), p < 0.001; HR = 1.6 (95% CI 1.1–2.2), p = 0.01), respectively. Besides, positive resection margins and multiple lymph node involvement were found to cause a statistically significant impact on the OS (HR = 3.6 (95% CI 2.0–6.5), p < 0.001; HR = 3.7 (95% CI 2 5–5.6), p < 0.001), respectively. A tumor grade tended to worsen OS (HR = 1.4 (95% CI 1.0–1.9), p = 0.053). Conclusion: Stage IVA, B, the presence of surgical complications, the retromolar trigone subsite, positive resection margins, multiple lymph node involvements and high-grade tumor were found to be significant clinical and pathological prognostic factors in patients with stage III–IVA-B OSCC.

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Prognostic impact of the level of nodal involvement: retrospective analysis of patients with advanced oral squamous cell carcinoma

Cited by 10 publications

References 22 publications

Clinico-pathological prognosticators in oral squamous cell carcinoma

Clinico-pathological prognosticators in oral squamous cell carcinoma

Multicenter retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with level IV/V metastasis

Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma

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