Prognostic importance of neutrophil / lymphocyte and lymphocyte / crp ratio in cases with malignant bowel obstruction

Daldal, Emin; Akbaş, Ahmet; Dasiran, Fatih; Dagmura, Hasan; Bakir, Huseyin; Okan, İsmail

doi:10.5455/medscience.2019.08.9114

Cited by 2 publications

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“…11 In the second study, he deduced that the combination of lymphocyte count along with C-reactive protein levels was more correlated with recurrence, overall survival (OS), and disease-free survival (DFS) than other biomarkers in CRC patients. 11 Also, Daldal et al 21 concluded that low LCR values could be used as poor prognosis predictors in malignant bowel obstruction cases. The only CLR-cancer relation investigated study was about the prognosis of hepatocellular carcinoma after surgical resection.…”

Section: Discussionmentioning

confidence: 99%

The predictive power of C‐reactive protein‐ lymphocyte ratio for in‐hospital mortality after colorectal cancer surgery

et al. 2021

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Background The relation between immunity, inflammation, and tumor development and progression has been emphasized in colorectal cancer widely and the prognosis is linked to the inflammatory reaction of the host as well as the biological behavior of the tumor. Aim In this study, we aimed to find out the predictive power of C‐reactive protein‐ lymphocyte ratio (CLR) for in‐hospital mortality after colorectal surgery. Methods and Results A series of 388 CRC patients were enrolled in the present retrospective study which was conducted in a tertiary state Hospital in Ankara, Turkey. In‐hospital mortality was the main outcome to evaluate the predictive power of inflammatory markers, while the other outcomes that would be evaluated as separate variables were LOS in hospital and LOS in ICU. In this study, there were 260 males and 128 females, and the mean age was 60.9. The in‐hospital mortality rate was 3.4% (n = 13) and age, APACHE II score and Charlson comorbidity index score were related to in‐hospital mortality statistically. The mean LOS in the hospital was 13.9 days and LOS in ICU was 4.5 days. The CRP levels and the CLR levels were higher both in the preoperative and postoperative periods in the mortality (+) group and the difference was significant statistically (P = .008/ .002 and .004/ <.001, respectively). CLR in the postoperative period had the best predictive power with AUC: 0.876. Conclusion In conclusion, within the context of our study there appears to be a relationship between CLR, as measured on day 2 postoperatively, and in‐hospital mortality. It is observed to be more effective than NLR, ALC, and CRP.

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Section: Discussionmentioning

confidence: 99%

The predictive power of C‐reactive protein‐ lymphocyte ratio for in‐hospital mortality after colorectal cancer surgery

et al. 2021

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“…[7] There have been recent reports about using the ratios of these inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-C-reactive protein ratio (LCR), for early inflammation markers in AA diagnosis. [4,8] AA causes the initiation of an inflammatory process secondary to bacterial infection in the body, resulting in the formation of an acute phase response by the body against the pathological agent. Proteins whose serum or plasma levels increase or decrease during this period are called acute phase proteins (APP).…”

Section: Introductionmentioning

confidence: 99%

The value of inflammatory markers in diagnosing acute appendicitis in pregnant patients

Akbaş

Kasap

Hacım

et al. 2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute appendicitis (AA) is the most common extra-obstetric condition requiring surgery during pregnancy. AA diagnosis is made by laboratory tests along with anamnesis and physical examination findings. Due to the physiological and anatomical changes during the pregnancy, AA diagnosis is more challenging in pregnant women compared to non-pregnant patients. The present study evaluated the significance of white blood cell counts (WBC), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CAR) and lymphocyte-to-C-reactive protein ratio (LCR) to diagnose acute appendicitis during pregnancy. METHODS:Pregnant patients admitted to General Surgery Inpatient Clinic with AA pre-diagnosis in September 2015-December 2019 period were screened using International Statistical Classification of Diseases and Related Health Problems-10 (ICD-10) diagnosis code (K35= acute appendicitis, Z33= pregnancy), and AA patients were identified retrospectively. The patients were divided into two groups. The Group I included the patients who had appendectomy due to AA and had a suppurative appendicitis diagnosis based on the pathological evaluation. On the other hand, Group II had the patients admitted as an inpatient with AA pre-diagnosis, but discharged from the hospital with full recovery without operation. Group III, i.e., the control group, on the other hand, was constituted by 32 randomly and prospectively recruited healthy pregnant women who were willing to participate in the study and who had matching study criteria among the patients followed in Obstetrics and Gynecology outpatient clinic of our hospital. RESULTS:This study included 96 pregnant women with an average age of 29.20±4.47 years (32 healthy pregnant women, 32 pregnant women followed for acute abdominal observation and 32 pregnant women who underwent appendectomy). Of these patients, three cases who turned out not to have suppurative appendicitis (negative appendectomy) and two cases found to have perforated appendicitis based on intraoperative and histopathological evaluations were excluded from this study. The results showed that Group I patients had significantly higher WBC (p=0.001), CAR (p=0.001) and NLR (p=0.001), but significantly lower LCR values (p=0.001) compared to the Groups II and III. Besides, based on logistic regression analysis, it was revealed that higher WBC, CAR and NLR values and lower LCR values were independent variables that could be used for the diagnosis of AA in pregnant women. CONCLUSION:Considering WBC, NLR, CAR and LCR parameters in addition to medical history, physical examination and imaging techniques could help clinicians diagnose acute appendicitis in pregnant women.

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Prognostic importance of neutrophil / lymphocyte and lymphocyte / crp ratio in cases with malignant bowel obstruction

Cited by 2 publications

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The predictive power of C‐reactive protein‐ lymphocyte ratio for in‐hospital mortality after colorectal cancer surgery

The predictive power of C‐reactive protein‐ lymphocyte ratio for in‐hospital mortality after colorectal cancer surgery

The value of inflammatory markers in diagnosing acute appendicitis in pregnant patients

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