Prognostic importance of various clinicopathological features in papillary thyroid carcinoma

Akslen, Lars A.; Myking, Andreas O.; Salvesen, Helga B.; Varhaug, Jan Erik

doi:10.1016/0959-8049(93)90574-y

Cited by 85 publications

(54 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Future studies should be conducted prospectively with a large number of patients from different centres, to enable effective generalization. A number of studies have observed that males have poorer clinical outcomes than females, however, the current study found no significant difference between genders with regard to clinical outcome or prognosis (6,(18)(19)(20). At the beginning of the study, involvement of nodes was more common among males compared with females (0.045), however, this difference was not significant based on multivariate analysis.…”

Section: Discussioncontrasting

confidence: 48%

Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

Lei

Ding

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

Abstract. Differentiated thyroid carcinoma (DTC) is one of the most common metabolic disorders and accounts for 98% of all cases of thyroid cancer. Previously, a number of studies have investigated the prognostic factors associated with well-differentiated thyroid carcinoma (WDTC); however, these studies yielded conflicting results. The current study used a retrospective study design to collect data from WDTC patients who had received the same treatment regimen from the same institute, with a minimum follow-up of 10 years. The De Groot staging system was used to classify WDTC in a total of 320 patients (240 females and 80 males). Among the subjects, the pathological subtypes identified were as follows: Papillary carcinoma (240 cases, 75%), follicular carcinoma (67 cases, 21%) and Hürthle cell carcinoma (13 cases, 4%). Prognostic factors that significantly affected the clinical outcome of the disease were advanced age (P=0.001), tumor size (P=0.03), presence of thyroglobulin (P=0.001) and De Groot stage (P=0.005). The 10-year follow-up study revealed that WDTC is associated with a high survival rate of 96% (307/320 patients survived) and a low mortality rate (4%).

show abstract

Section: Discussioncontrasting

confidence: 48%

Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

Lei

Ding

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…On the contrary, more than 4 foci of vascular invasion are associated with a poor prognosis, mainly in follicular carcinomas (30)(31)(32). This situation seems to be uncommon in papillary carcinomas, even more in micro PTC, with a prevalence of less than 4% (25,26,28,(33)(34)(35). In fact, none of the 63 patients from our cohort had vascular invasion in more than 4 foci in the pathological review.…”

Section: Resultsmentioning

confidence: 77%

Impact of historic histopathologic sample review on the risk of recurrence in patients with differentiated thyroid cancer

Pitoia¹,

Jerkovich²,

Urciuoli³

et al. 2018

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

Objective: To compare the historic risk of recurrence (RR) and response to therapy to risk stratification estimated with historical pathology reports (HPRs) and contemporary re-review of the pathological slides in patients with differentiated thyroid cancer (DTC). Subjects and methods: Out of 210 DTC patients with low and intermediate RR who underwent total thyroidectomy and remnant ablation in our hospital, 63 available historic pathologic samples (HPS) were reviewed. The RR and the response to therapy were evaluated considering historical histological features (histological type, tumor size, capsular invasion, number of lymph node metastases) and then, reassessed after observing additional histological features (vascular invasion, extrathyroidal extension, size of lymph node metastases, presence of extranodal extension, and/or status of the resection margins).

show abstract

“…In addition, certain pathological features such as marked nuclear atypia, necrosis or vascular invasion are also important (Tennvall et al, 1985;Schindler et al, 1991;Akslen et al, 1993). This information may improve the risk estimation for individual patients.…”

mentioning

confidence: 99%

Prognostic impact of EGF-receptor in papillary thyroid carcinoma

Akslen¹,

Myking²,

Salvesen³

et al. 1993

Br J Cancer

View full text Add to dashboard Cite

Summary In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGFreceptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas.The prognosis of patients with papillary thyroid carcinoma has previously been described in several reports (Byar et al., 1979; Tubiana et al., 1985;Carcangiu et al., 1985;Akslen et al., 1991), and the influence of sex, age and tumour stage has been discussed. In addition, certain pathological features such as marked nuclear atypia, necrosis or vascular invasion are also important (Tennvall et al., 1985;Schindler et al., 1991;Akslen et al., 1993). This information may improve the risk estimation for individual patients.In recent years, alterations in various growth factors and their receptors have been established as important features of the neoplastic process (Wynford-Thomas, 1991), among them epidermal growth factor (EGF) and its receptor (EGF-R). EGF is known to induce cell proliferation in several tissues, and its effect is mediated via a tyrosine kinase type of receptor (Carpenter & Cohen, 1979). It has previously been shown by different methods that EGF-receptors are expressed in papillary thyroid carcinomas (Duh et al., 1985;Lemoine et al., 1991;Mizukami et al., 1991; Mizukami et al., 1992), but the biological significance of this finding in terms of patient prognosis is not known. The purpose of the present study was therefore to perform a retrospective immunohistochemical study of EGF-R expression in a series of papillary thyroid carcinomas with special reference to its prognostic importance. Material and methodsPatients This material has been described previously . Briefly, all 263 patients who were surgically treated for thyroid cancer at the Department of Surgery, Haukeland Hospital, University of Bergen in the period 1971-1985 have been studied retrospectively. After histological revision and subtyping of the carcinomas according to the WHO criteria (Hedinger, 1988), 173 cases were found to be papillary carcinomas with a known primary tumour. One of the main results from our previous study was that very few events were observed in tumours with a diameter of 10 mm or below (microcarcinomas according to the WHO criteria). These were therefore excluded, thereby concentrating on clinically significant papillary carcinomas. Sufficient materia...

show abstract

Prognostic importance of various clinicopathological features in papillary thyroid carcinoma

Cited by 85 publications

References 18 publications

Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

Impact of historic histopathologic sample review on the risk of recurrence in patients with differentiated thyroid cancer

Prognostic impact of EGF-receptor in papillary thyroid carcinoma

Contact Info

Product

Resources

About