Prognostic Importance of Vascular Invasion in Papillary Thyroid Carcinoma

Gardner, Raymond E.; Tuttle, R. Michael; Burman, Kenneth D.; Haddady, Shirin; Truman, Catherine; Sparling, Yvonne; Wartofsky, Léonard; Sessions, Roy B.; Ringel, Matthew D.

doi:10.1001/archotol.126.3.309

Cited by 102 publications

(74 citation statements)

References 17 publications

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“…On the contrary, more than 4 foci of vascular invasion are associated with a poor prognosis, mainly in follicular carcinomas (30)(31)(32). This situation seems to be uncommon in papillary carcinomas, even more in micro PTC, with a prevalence of less than 4% (25,26,28,(33)(34)(35). In fact, none of the 63 patients from our cohort had vascular invasion in more than 4 foci in the pathological review.…”

Section: Resultsmentioning

confidence: 59%

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Impact of historic histopathologic sample review on the risk of recurrence in patients with differentiated thyroid cancer

Pitoia¹,

Jerkovich²,

Urciuoli³

et al. 2018

Archives of Endocrinology and Metabolism

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Objective: To compare the historic risk of recurrence (RR) and response to therapy to risk stratification estimated with historical pathology reports (HPRs) and contemporary re-review of the pathological slides in patients with differentiated thyroid cancer (DTC). Subjects and methods: Out of 210 DTC patients with low and intermediate RR who underwent total thyroidectomy and remnant ablation in our hospital, 63 available historic pathologic samples (HPS) were reviewed. The RR and the response to therapy were evaluated considering historical histological features (histological type, tumor size, capsular invasion, number of lymph node metastases) and then, reassessed after observing additional histological features (vascular invasion, extrathyroidal extension, size of lymph node metastases, presence of extranodal extension, and/or status of the resection margins).

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Section: Resultsmentioning

confidence: 59%

“…The presence of vascular invasion is recognized as a variable that has a negative impact on the RR (25)(26)(27), and it should be informed in the pathological report. It is diagnosed as a direct tumor extension into the blood vessel lumen typically attached to the wall and covered by a fibrin thrombus (27).…”

Section: Resultsmentioning

confidence: 99%

Impact of historic histopathologic sample review on the risk of recurrence in patients with differentiated thyroid cancer

Pitoia¹,

Jerkovich²,

Urciuoli³

et al. 2018

Archives of Endocrinology and Metabolism

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“…29,30 In our study, higher MVD, as an indicator of the extent of angiogenesis, was strongly associated with the presence of vascular invasion. Histologically determined vascular invasion may be considered a sign of a greater tendency toward hematogenous spread of tumor cells and could result in increased formation of metastases.…”

Section: 7supporting

confidence: 54%

Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Skuletic¹,

Radosavljević²,

Pantic³

et al. 2017

Polish Archives of Internal Medicine

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“…[10][11][12][13][31][32][33] Nishida et al 33 reported vascular invasion in 46.9% of papillary thyroid carcinomas and distant metastases in only 8% of angioinvasive papillary thyroid carcinomas, suggesting that the criteria applied were not specific enough to identify high risk patients. Our review identified rigid criteria of vascular invasion in only 3% of thyroid carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation

2011

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There are many controversies involving the diagnostic criteria and treatment of well-differentiated thyroid carcinoma. Vascular invasion has been identified as an important and independent prognosticator in many cancers. The majority of pathologists recognize the importance of vascular invasion as a diagnostic marker of malignancy in follicular lesions of thyroid; however, several reports have suggested that angioinvasion is not a predictor of bad prognosis in thyroid carcinomas. We suggest that the criteria for diagnosing angioinvasion in thyroid carcinomas as well as in other endocrine tumors are inconsistent and the controversy may be attributed to application of inappropriate criteria. We carried out a study of a potential cause of artefactual vascular invasion in a series of autopsy thyroids and established the morphology of mimics of angioinvasion. We then reviewed retrospectively the clinicopathological features of a series of 4000 thyroid carcinomas of follicular epithelial derivation to identify the features and significance of the most rigid criteria of vascular invasion: tumor cells invading through a vessel wall and thrombus adherent to intravascular tumor. These features were identified in 118 (3%) lesions. Follow-up information was available for 98 patients. Of these, 35% developed distant metastases. When using the rigid criteria, B1/3 of angioinvasive well-differentiated thyroid carcinomas and 1/2 of angioinvasive poorly differentiated thyroid carcinomas developed distant metastases at a mean 5.3 years of follow-up. Our results indicate that the application of rigid criteria for vascular invasion provide a clinically relevant prediction of distant metastasis in patients with thyroid carcinomas, especially in well-differentiated thyroid carcinomas.

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Prognostic Importance of Vascular Invasion in Papillary Thyroid Carcinoma

Cited by 102 publications

References 17 publications

Impact of historic histopathologic sample review on the risk of recurrence in patients with differentiated thyroid cancer

Impact of historic histopathologic sample review on the risk of recurrence in patients with differentiated thyroid cancer

Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation

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