Prognostic indicators estimated by Tc-GSA in acute liver damage

Living donor liver transplantation for fulminant hepatic failure

“…ASSESSMENT OF THE likelihood of spontaneous recovery of an injured native liver is critical in the decision to perform transplantation, given that transplantation commits the patients to a life‐long need for immunosuppression to prevent graft rejection. To judge the ability for spontaneous recovery, a number of prognostic criteria were recently proposed, including serum lactate level, 36 serum phosphate level, 37 alpha‐fetoprotein (AFP), 38 systematic inflammatory response (SIRS), 39 Apache II score 40 and 99mTc‐GSA 41 …”

Separate analysis of asialoglycoprotein receptors in the right and left hepatic lobes using 99mTc-GSA SPECT in patients with acute hepatic damage

“…To date, the indices that have been used when assessing hepatic function by 99m Tc-GSA are: [R] 0 , which reflects the receptor concentration; HH15, which reflects the ratio of disappearance of 99m Tc-GSA from the blood; LHL15, which reflects the hepatic uptake ratio of 99m Tc-GSA; GSA-Rmax, which reflects the maximal receptor binding rate of 99m Tc-GSA; and Ro, which reflects the amount of ASGPRs present [ [18][19][20][21][22][23]. These indices are obtained by measuring of the isotope count, with the region of interest set over the heart, the whole liver and the right and middle lung areas.…”

Acute liver failure and living donor liver transplantation

“…Among the factors listed in Table 1, the most important factors for predicting survival from ALF are the degree of encephalopathy, patient age, and the cause of ALF. Other factors associated with the prognosis of ALF include severity of systemic inflammatory response syndrome, 43,44,57 serum alpha fetoprotein levels, 58 serum phosphate levels, 59,60 findings from computed tomography scans of the liver, 61,62 99mTc‐GSA, 63 cytokine levels, 64 and serum lactate levels 65,66 …”