Prognostic Interest in Discriminating Muscularis Mucosa Invasion (T1a vs T1b) in Nonmuscle Invasive Bladder Carcinoma: French National Multicenter Study with Central Pathology Review

Rouprêt, Morgan; Seisen, Thomas; Compérat, Éva; Larré, S.; Mazerolles, Catherine; Gobet, Françoise; Fetissof, F; Fromont, Gaëlle; Safsaf, A.; d’Arcier, B. Faivre; Celhay, O.; Validire, Pierre; Rozet, François; Irani, Jacques; Soulié, M.; Pfister, Christian; d'Urologie, Comité de Cancérologie de l'Association Française

doi:10.1016/j.juro.2012.11.120

Cited by 62 publications

(50 citation statements)

References 26 publications

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“…1,2 In 2004, a two-tiered new classification system for grade (low vs high grade) was accepted by the WHO to improve reproducibility and prognosis compared with the "old" WHO 1973 classification system. 3,19 Looking at the results of the present study and many other reports, the WHO 3,6,9,[19][20][21] This is the main reason why the EAU still holds onto WHO 1973 in their NMIBC guidelines. 3,19 Looking at the results of the present study and many other reports, the WHO 3,6,9,[19][20][21] This is the main reason why the EAU still holds onto WHO 1973 in their NMIBC guidelines.…”

Section: Discussionsupporting

confidence: 51%

“…3,19 Looking at the results of the present study and many other reports, the WHO 3,6,9,[19][20][21] This is the main reason why the EAU still holds onto WHO 1973 in their NMIBC guidelines. [1][2][3]5,6,9,16,20,21 Traditionally, T1 BC has been substaged according to invasion above (T1a) and in/beyond (T1b/c) the muscularis mucosae, a thin layer of smooth muscle fibers within the lamina propria. Stage T1 substage has been shown to be highly prognostic in many studies.…”

Section: Discussionsupporting

confidence: 51%

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Infiltrative lamina propria invasion pattern as an independent predictor for cancer‐specific and overall survival of instillation treatment‐naïve stage T1 high‐grade urothelial bladder cancer

Otto¹,

Breyer²,

Bertz

et al. 2018

Int J of Urology

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Section: Discussionsupporting

confidence: 51%

Section: Discussionsupporting

confidence: 51%

Infiltrative lamina propria invasion pattern as an independent predictor for cancer‐specific and overall survival of instillation treatment‐naïve stage T1 high‐grade urothelial bladder cancer

Otto¹,

Breyer²,

Bertz

et al. 2018

Int J of Urology

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“…Conversely, in the largest of these studies, involving 587 pT1 patients from six hospitals and median follow‐up of 35 months, Rouprêt et al . identified significantly worse recurrence‐free survival, progression‐free survival and cancer‐specific survival in patients with invasion beyond the muscularis mucosae . Furthermore, in the only prospective study of the group, Orsola et al .…”

Section: Stage Pt1 Carcinomamentioning

confidence: 98%

Staging of bladder cancer

et al. 2018

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Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging Manual, 8th edition, should be the basis for staging of urinary bladder tumours. It is unfortunate that the International Union Against Cancer (UICC) 8th edition failed to incorporate new data which is considered in the AJCC 8th edition. Thus, the AJCC 8th edition is the focus of this review. Several critical changes and clarifications are made by the AJCC 8th edition relative to the 7th edition. Although the most obvious changes in the 8th edition are in the N (i.e. perivesical lymph node involvement now classified as N1) and M (i.e. M1 is subdivided into M1a and M1b) categories, several points are clarified in the T category (e.g. substaging of pT1 should be attempted). Further optimisation, however, is required. No particular method of substaging pT1 is formally recommended. In this review, these modifications are discussed, as well as points, which require further study and optimisation.

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“…In a multivariate analysis, pT1b tumour stage was significantly associated with recurrence‐free ( P = 0.03), progression‐free ( P = 0.0002) and cancer‐specific ( P = 0.02) survival. The authors considered MM invasion to be highly predictive of tumour behaviour …”

Section: Substaging Of Pt1 Tumoursmentioning

confidence: 99%

Immunochemical and molecular assessment of urothelial neoplasms and aspects of the 2016 World Health Organization classification

Compérat

Varinot

2016

Histopathology

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The new World Health Organization classification of tumours of the urinary system and male genital organs (4th edn) has several changes from previous versions, and was published in January 2016. New pathways have been discovered in the development of bladder cancer, and were included in this new classification. Guidance from the International Collaboration on Cancer Reporting (ICCR) helped to clarify open questions, in conjunction with the new classification. The histological groups of urothelial carcinoma evolved. Grading remained the same, despite controversy among European urologists. Substaging of pT1 tumours is recommended for the first time, and the ICCR has made recommendations on how to report this. Furthermore, worldwide advice has been published on the use of immunohistochemistry, and recommendations have been made to try to standardize the handling of bladder cancer from a histopathological point of view. At a molecular level, bladder cancer groups have been stratified, and an upcoming molecular classification permits a novel view of this malignancy. This review will try to summarize the most important changes.

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Prognostic Interest in Discriminating Muscularis Mucosa Invasion (T1a vs T1b) in Nonmuscle Invasive Bladder Carcinoma: French National Multicenter Study with Central Pathology Review

Cited by 62 publications

References 26 publications

Infiltrative lamina propria invasion pattern as an independent predictor for cancer‐specific and overall survival of instillation treatment‐naïve stage T1 high‐grade urothelial bladder cancer

Infiltrative lamina propria invasion pattern as an independent predictor for cancer‐specific and overall survival of instillation treatment‐naïve stage T1 high‐grade urothelial bladder cancer

Staging of bladder cancer

Immunochemical and molecular assessment of urothelial neoplasms and aspects of the 2016 World Health Organization classification

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