Prognostic role of CD10⁺ myeloid cells in association with tumor budding at the invasion front of colorectal cancer

Abstract

The expression of CD10 in tumor cells has been reported to correlate with liver metastasis in colorectal cancer (CRC). However, fibroblasts and immune cells positive for CD10 at the tumor invasion front have not been comprehensively studied. We classified CD10 expression patterns into three types of cells, tumor cells (tCD10), stromal myofibroblasts (sCD10), and immune cells (iCD10), and investigated their correlation with the expression of transforming growth factor-b (TGF-b1) protein and tumor budding grade. Several cell surface markers were stained to detect the phenotype of iCD10 + cells, including CD3, CD20, CD11b, CD14, CD15, and CD163. Specimens and follow-up data of 206 CRC patients were examined. In multivariate analysis, iCD10 could be an independent prognostic factor for both recurrence-free survival and overall survival in stage I-III CRC (hazard ratio, 2.522 [1.299-4.896], P = 0.006; 2.890 [1.357-6.157], P = 0.006, respectively). The expression of sCD10 and iCD10 was strongly correlated with TGF-b1 expression in tumor cells and tumor budding grade. The phenotype of iCD10 + cells was CD11b + and CD15 + granulocytes. The infiltration of sCD10 + fibroblasts and iCD10 + granulocytes at the tumor invasion front might interact with TGF-b1 protein expression and enhance tumor budding grade. The expression level of iCD10 at the tumor invasion front represented an independent prognostic biomarker in stage I-III CRC and could be integrated into a new staging system. (Cancer Sci 2011; 102: 1724-1733

Tumoral CD10 expression correlates with high-grade histology and increases risk of recurrence in patients with stage I lung adenocarcinoma

“…14 Additionally, CD10 expression was observed in tumor-infiltrating granulocytes and was correlated with worse survival. 15 In prostate carcinoma, tumoral CD10 expression was used to identify subsets of patients with poor prognoses for survival, higher risk of lymph node metastases, and higher Gleason grades. 16,17 By contrast, in hematopoietic tumors such as malignant lymphoma, tumoral CD10 expression was correlated with better survival.…”

Epithelial–mesenchymal transition in colorectal cancer metastasis: A system review

“…It has been reported that TGF-␤ is an important cytokine involved in the crosstalk between tumor cells and stroma cells [2,59]. The infiltration of CD10 + myeloid cells at the invasion front interact with TGF-␤ and enhance the tumor-budding grade [167]. Selective and transient loss of the basement membrane (BM) at the invasive front is correlated with increased distant metastasis and poor patient survival in CRC.…”

Does CD10 Expression Predict Lymph Node Metastasis in Colorectal Cancer?

“…1 over the last decade, multiple studies have focused on CD10 as a potential marker for high-risk colorectal cancer. [1][2][3][4][5][6][7][8][9][10][11][12] CD10, a cell membrane metallopeptidase, was initially used in the diagnosis of acute lymphocytic leukemia; studies in the last decade, mostly from Japan, have repeatedly shown CD10 to be linked to colorectal cancer as well. 2 early work has demonstrated that CD10 expression is integral to colorectal cancer progression and invasion, [3][4][5] whereas more recent studies have shown CD10 presence as a significant predictor of liver metastasis.…”