Tumoral CD10 expression correlates with high-grade histology and increases risk of recurrence in patients with stage I lung adenocarcinoma

Abstract

Objective CD10 (neutral endopeptidase) is expressed in various normal and tumor cells, and its biological function can be controlled through enzymatic activity and signaling pathways. We investigated whether CD10 expression predicted disease recurrence and whether it correlated with histologic subtypes of stage I lung adenocarcinoma. Material and Methods We reviewed tumor slides of resected pathologic stage I lung adenocarcinomas (1995–2009). Tumors were classified according to the IASLC/ATS/ERS classification. CD10 immunohistochemistry was performed using tissue microarrays (n = 915). We combined the intensity (0–3) and distribution scores (0–2) for CD10 to create a total score (0–5). Risk of recurrence was estimated using competing risks methods. Results In the training cohort (n = 313), risk of recurrence of patients with high tumoral CD10 (score > 1, n = 57) was significantly higher (5-year cumulative incidence of recurrence [CIR], 37%) than in those with low CD10 (score ≤ 1; n = 256; 5-year CIR, 16%; P < 0.001); this finding was confirmed in the validation cohort (n = 602, P = 0.036). High tumoral CD10 was associated with higher risk of recurrence in acinar (P = 0.007) and papillary predominant tumors (P = 0.022). High tumoral CD10 was most frequently identified in micropapillary predominant (41%) and solid predominant tumors (34%). On multivariate analysis of intermediate-grade tumors, high tumoral CD10 remained a significant independent risk factor of recurrence (hazard ratio, 1.88; P = 0.025). Conclusion In stage I lung adenocarcinoma, tumoral CD10 correlated with high-grade histology and was an independent predictor of recurrence in intermediate-grade tumors.

Clinical impacts of a micropapillary pattern in lung adenocarcinoma: a review

“…Apart from the aforementioned reports, there are other biomarkers associated with MPP that have been reported, such as higher expression of cytoplasmic maspin, 64 Notch-1, 65 and tumoral CD10. 66 However, there is a lack of additional literature to validate the correlations between these biomarkers and the presence of MPP, so we will not clarify them in detail here. MPPAC also has molecular markers specifically related to ADC, for example, TTF-1.…”

High expression of CD10 in anaplastic thyroid carcinomas

“…Several reports have indicated that many human epithelial tumours express stromal CD10 . These reports demonstrated that a high level of CD10 expression in neoplasms tended to be associated with poor clinical outcomes.…”

“…Both neoplastic cells (mostly of epithelial cell origin) and non‐neoplastic intratumoral stromal cells express CD10. Although non‐neoplastic cells from some organs express CD10, and the tumours arising from these organs may also express CD10, it is notable that CD10 can also be expressed in neoplastic cells arising from organs with normal cells that do not express CD10 …”

Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non‐Small Cell Lung Cancer

“…Second, some differentially expressed proteins that did not overlap in the serum and cell lines have great diagnostic potential. Of the 50 differentially expressed proteins in the advanced NSCLC group versus the early NSCLC group, neprilysin, CD44, and basigin were obviously increased in patients with advanced NSCLC. These proteins are widely reported to be closely associated with cancer progression and metastasis in cell line and tissues.…”