Prognostic role of heart rate variability in patients with a recent acute myocardial infarction

Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

“…Many studies have also shown that even an alteration of cardiac ANS activity towards a predominance of adrenergic tone is associated with an increased risk of cardiac events in several disease settings [9][10][11][12], including diabetes [34].…”

“…Moreover, markers of inflammation predict cardiovascular events in several disease states [4][5][6]. Increased platelet activation [7,8] and sympathovagal imbalance of cardiac autonomic nervous system (ANS) activity [9][10][11][12] are also well-known predictors of acute coronary events.…”

Particle Effects on Heart-Rate Regulation in Senescent Mice

“…In contrast, a third study demonstrated increased high-frequency HRV in the short term, while low-frequency HRV decreased. Because changes in HRV forecast susceptibility to cardiac morbidity and mortality (Bigger et al, 1995;Fei et al, 1994;Tsuji et al, 1994Tsuji et al, , 1996Lanza et al, 1998;Algra et al, 1993;Ponikowski et al, 1997), some resolution to this controversy is critical. Reduced HRV, for example, has been used to predict increased risk of adverse cardiac events including sustained ventricular tachycardia (Fei et al, 1994).…”

Markers of Endothelial Activation and Impaired Autonomic Function in Patients with Acute Coronary Syndromes – Potential Prognostic and Therapeutic Implication

“…Decreased values of HRV variables, including LF, may reflect reduced vagal tone or predominant sympathetic influence to the heart. The presence of frequent or complex non-sustained VA in the context of sympathovagal imbalance can increase the susceptibility to fatal VA, in particular during myocardial ischaemia [Kent et al, 1973;Lanza et al, 1998Schwartz et al,1988]. On the other hand, VA and depressed HRV are unlikely to be associated with the triggers of acute MI, as they were not predictive of non-fatal MI in hospital or at six-month follow up.…”

“…Nonetheless, the pathologic role of different soluble adhesion molecules in various stages of coronary artery disease is not fully defined. Two electrocardiographic markers -ventricular arrhythmias (VA), [Bigger et al, 1981;Farrell et al, 1991;Kostis et al, 1987] and impaired cardiac autonomic function, as indicated by depressed heart rate variability (HRV), [Bigger at al., 1992;Farrell et all, 1991;Hartikainen et al, 1996;Kleiger et al, 1987;Lanza et al, 1998La Rovere et al, 1998] have been shown to predict mortality among patients recovering from acute myocardial infarction (MI). However there are only limited data about the prognostic value of depressed HRV in the whole spectrum of patients with ACS and few attempts to quantify the exact value of soluble adhesion molecules and HRV in the cumulative risk assessment of patients with ACS [Kennon et al, 2008;.…”