Prognostic role of HOTAIR in four estrogen-dependent malignant tumors: a meta-analysis

Li, Jing; Wen, Wen; Zhao, Shu; Wang, Jingxuan; Chen, Jingyu; Wang, Yanrong; Zhang, Qingyuan

doi:10.2147/ott.s84687

Cited by 23 publications

(17 citation statements)

References 34 publications

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“…The incidence of lymph node metastasis was illustrated to be higher in cancer patients with high HOTAIR expression compared to patients with low HOTAIR expression (23). Likewise, HOTAIR was indicated to be a potential predictor of poor relapse-free survival, metastasis-free survival and disease-free survival in cervical, ovarian, breast and endometrial cancer patients (24).…”

Section: Discussionmentioning

confidence: 96%

High expression of long non‑coding HOTAIR correlated with hepatocarcinogenesis and metastasis

Zhong

Luo

et al. 2017

Mol Med Report

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HOX transcript antisense RNA (HOTAIR), a newly discovered long noncoding RNA (lncRNA), has been reported to be a poor prognostic marker in many types of cancers. The current study attempted to investigate the biological roles and clinicopathlogical implications of HOTAIR in hepatocellular carcinoma (HCC), as well as understand the molecular mechanisms of HOTAIR in HCC progression. HOTAIR expression in 95 HCC patients with paired HCC tissues and adjacent non‑cancer tissues were investigated using quantitative reverse transcription‑polymerase chain reaction. The association between HOTAIR expression and clinicopathological features was assessed. The effects of HOTAIR were examined in vitro assays by silencing the lncRNA. Pathway analyses were performed to illustrate the biological functions of the HOTAIR and coexpression genes. The expression level of HOTAIR was observed significantly higher in the HCC tissue than the adjacent non‑tumor tissue. HOTAIR expression levels were significantly higher in tumor samples from patients with distant metastasis, advanced stage, portal vein tumor embolus, vasoinvasion, tumor capsular infiltration or positive nm23 expression than those from patients without these conditions, correspondingly. The silencing of HOTAIR in liver cancer cells induced the inhibition of cell proliferation and promotion of apoptosis. Several pathways such as extracellular matrix‑receptor interaction, focal adhesion, pathways in cancer were annotated with the HOTAIR and coexpression genes. In summary, the present analysis indicates that HOTAIR might be an oncogene in HCC. It functions though promoting tumor cell growth and inhibiting apoptosis. HOTAIR may potentially be involved in HCC metastatic progression by several pathways correlated to cell adhesion, and may be a therapeutic target in future.

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Section: Discussionmentioning

confidence: 96%

High expression of long non‑coding HOTAIR correlated with hepatocarcinogenesis and metastasis

Zhong

Luo

et al. 2017

Mol Med Report

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“…Predominantly, lncRNAs have been shown to regulate cancer cell viability, apoptosis, invasion and metastasis [ 28 - 34 ]. As is well-known, HOTAIR could regulate breast cancer proliferation and chemo-resistance as an oncogenic lncRNA [ 43 - 47 ]. Since the dysregulated lncRNAs between TNBC and adjacent normal tissues have been identified [ 35 , 36 ], there is still no information on the differentially expressed lncRNAs between TNBC and non-TNBC tissues.…”

Section: Discussionmentioning

confidence: 99%

LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer

et al. 2016

Oncotarget

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Triple negative breast cancer (TNBC) is an aggressive type of breast cancer with high heterogeneity. To date, there is no efficient therapy for TNBC patients and the prognosis is poor. It is urgent to find new biomarkers for the diagnosis of TNBC or efficient therapy targets. As an area of focus in the post-genome period, long non-coding RNAs (lncRNAs) have been found to play critical roles in many cancers, including TNBC. However, there is little information on differentially expressed lncRNAs between TNBC and non-TNBC. We detected the expression levels of lncRNAs in TNBC and non-TNBC tissues separately. Then we analyzed the lncRNA expression signature of TNBC relative to non-TNBC, and found dysregulated lncRNAs participated in important biological processes though Gene Ontology and Pathway analysis. Finally, we validated these lncRNA expression levels in breast cancer tissues and cells, and then confirmed that 4 lncRNAs (RP11-434D9.1, LINC00052, BC016831, and IGKV) were correlated with TNBC occurrence through receiver operating characteristic curve analysis. This study offers helpful information to understand the initiation and development mechanisms of TNBC comprehensively and suggests potential biomarkers for diagnosis or therapy targets for clinical treatment.

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“…The association between HOTAIR and cervical cancer has also demonstrated that upregulation of HOTAIR promoted cervical carcinoma cells proliferation, invasion and migration [ 27 , 43 ]. In addition, in a meta-analysis containing eight eligible studies, zhang et al [ 44 ] showed that HOTAIR may be an indicator of poor prognosis in four main estrogen-dependent tumors, including cervical, ovarian, breast and endometrial cancers. The study of HOTAIR expression in the sera of cervical cancer patients indicate that the level of circulating HOTAIR may serve as a promising predicting and therapeutic target in cervical cancer[ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Long Non-Coding RNA HOTAIR Polymorphisms with Cervical Cancer Risk in a Chinese Population

et al. 2016

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Long non-coding RNAs (lncRNAs), HOTAIR has been reported to be upregulated in cervical cancer development and progression. However, SNPs (single nucleotide polymorphisms) in the lncRNAs and their associations with cervical cancer susceptibility have not been reported. In the current study, we hypothesized that SNPs within the lncRNA HOTAIR may influence the risk of cervical cancer. We performed a case-control study including 510 cervical cancer patients (cases) and 713 cancer-free individuals (controls) to investigate the association between three haplotype-tagging SNPs (rs920778, rs1899663 and rs4759314) in the lncRNA HOTAIR and the risk of cervical cancer. We found a strong association between the SNP rs920778 in the intronic enhancer of the HOTAIR and cervical cancer (P<10−4). Moreover, the cervical cancer patients with homozygous TT genotype were significantly associated with tumor-node-metastasis (TNM) stage. In vitro assays with allele-specific reporter constructs indicated that the reporter constructs bearing rs920778T allele conferred elevated reporter gene transcriptional activity when compared to the reporter constructs containing rs920778C allele. Furthermore, HOTAIR expression was higher in cervical cancer tissues than that in corresponding normal tissues, and the high expression was associated with the risk-associated allele T. In summary, our studies provide strong functional evidence that functional SNP rs920778 regulates HOTAIR expression, and may ultimately influence the predisposition for cervical cancer.

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Prognostic role of HOTAIR in four estrogen-dependent malignant tumors: a meta-analysis

Cited by 23 publications

References 34 publications

High expression of long non‑coding HOTAIR correlated with hepatocarcinogenesis and metastasis

High expression of long non‑coding HOTAIR correlated with hepatocarcinogenesis and metastasis

LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer

Association of Long Non-Coding RNA HOTAIR Polymorphisms with Cervical Cancer Risk in a Chinese Population

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