Prognostic Role of Maternal Neutrophil Gelatinase-Associated Lipocalin in Women with Severe Early-Onset Preeclampsia

Scazzochio, Elena; Munmany, Meritxell; García, Laura Baena; Meler, E.; Crispi, F.; Gratacós, Eduard; Figueras, F.

doi:10.1159/000356499

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…In our study, serum NGAL levels had a range of 15.26 -26.03 ng/mL with a homogenous distribution. These mean values were far below the values reported by Scazzochio et al (9). We did not have any maternal complications such as HELLP or eclampsia.…”

Section: Discussioncontrasting

confidence: 63%

“…Stepan et al (19) have shown that serum NGAL was significantly higher in women with EOPE compared to uncompli-cated pregnancy. Scazzochio et al (9) have shown that serum NGAL was significantly higher in women with early-onset severe preeclampsia compared to uncomplicated pregnancy. Maternal complications such as HELLP were more common with serum NGAL levels above 100 ng/mL, although neonatal complications were comparable.…”

Section: Discussionmentioning

confidence: 99%

“…Kim et al (6) have detected that plasma NGAL levels were increased in women with preeclampsia compared to normotensive controls. Moreover, Scazzochio et al (9) have shown that the elevated plasma NGAL levels are associated with increased risk of maternal complications in women with severe EOPE.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Güralp

Tüten²,

Öncül

et al. 2020

Gynecol Obstet Reprod Med

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Objective: To evaluate the serum neutrophil gelatinase-associated lipocalin levels in pregnant women with and without preeclampsia, early-onset preeclampsia and late-onset preeclampsia, preeclampsia with and without severe features, and investigate the correlation with the neonatal outcomes.Study Design: A total of 79 pregnant women, 27 with uncomplicated pregnancies, 30 with early-onset preeclampsia, and 22 with late-onset preeclampsia were evaluated in a cross-sectional study. Neutrophil gelatinase-associated lipocalin was measured with a colorimetric Sandwich-ELISA method. Age; body mass index; systolic and diastolic blood pressure; umbilical-artery Doppler results; serum urea, bilirubin, uric acid, AST, ALT; 24-hour protein test; birth-weight; and Apgar-scores were recorded. Results: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia (p<0.001); in women with early-onset preeclampsia compared to those with late-onset preeclampsia (p<0.001); and in women with late-onset preeclampsia compared to those without preeclampsia (p=0.028). Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features (p=0.076). The correlation analysis showed that neutrophil gelatinase-associated lipocalin was not affected by age or body mass index. Neutrophil gelatinase-associated lipocalin had a positive correlation with systolic and diastolic blood pressure and the umbilical-artery PI and RI. Serum neutrophil gelatinase-associated lipocalin had a positive correlation with serum urea (r=0.416, p=0.031) however had no significant correlation with birth-weight, Apgar-scores, uric acid and amount of proteinuria in women with preeclampsia. Conclusion: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia; in women with early-onset preeclampsia compared to those with late-onset preeclampsia, and in women with late-onset preeclampsia compared to women without preeclampsia. Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Güralp

Tüten²,

Öncül

et al. 2020

Gynecol Obstet Reprod Med

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“…There is a plethora of publications showing the utility of NGAL for diagnosing and assessing the severity of preeclampsia. 17 – 23 The increase in NGAL due to preeclampsia is attributed to the presence of endothelium dysfunction and systemic inflammation. 24 The range of serum NGAL reported in these previous studies is very wide.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury in Severe Preeclamptic Patients Admitted to Intensive Care Unit: Epidemiology and Role of Serum Neutrophil Gelatinase-associated Lipocalcin

Tyagi¹,

Yadav²,

Salhotra³

et al. 2021

Indian Journal of Critical Care Medicine

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A bstract Background Patients with preeclampsia admitted to the intensive care unit (ICU) may have risk factors for acute kidney injury (AKI). Although the use of neutrophil gelatinase-associated lipocalcin (NGAL) to predict AKI is previously validated, we could locate only scanty data regarding the epidemiology of AKI and role of NGAL in preeclamptic patients admitted to ICU. Methods Patients with preeclampsia admitted to our ICU were included. The incidence and severity of AKI during the entire ICU stay were assessed using kidney disease improving global outcomes criteria, while the a priori risk factors and serum NGAL were also evaluated. Results A total of 52 preeclamptic patients admitted to ICU were included, among whom the majority had eclampsia (75%). AKI developed in 25 (48.1%) patients with stages 1, 2, and 3 in 56, 36, and 8%, respectively. The incidence of sepsis (16 vs 0%), shock (40 vs 7.4%), and anemia (84 vs 59.3%) was significantly greater in patients with AKI ( p < 0.05). ICU mortality (28 vs 3.7%), duration of ICU, and hospital stay were significantly higher in patients who developed AKI ( p < 0.05). There was no association of serum NGAL [274 (240–335) ng/mL] with AKI or the mortality ( p = 0.725, 0.861); there was, however, a significant discriminatory value for eclampsia [ p = 0.019; area under curve = 0.736 (95% confidence interval: 0.569–0.904)]. Conclusions Although AKI is common among patients with preeclampsia admitted to ICU, serum NGAL does not predict its occurrence. How to cite this article Tyagi A, Yadav P, Salhotra R, Das S, Singh PK, Garg D. Acute Kidney Injury in Severe Preeclamptic Patients Admitted to Intensive Care Unit: Epidemiology and Role of Serum Neutrophil Gelatinase-associated Lipocalcin. Indian J Crit Care Med 2021;25(9):1013–1019.

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“…It has been shown that circulating levels of NGAL correlate with the presence and severity of preeclampsia [26]. It might be involved in the pathophysiology of preeclampsia and could be a marker for this syndrome.…”

Section: Commentsmentioning

confidence: 99%

Does maternal hydronephrosis have an impact on urinary neutrophil gelatinase-associated lipocalin (uNGAL) levels?

Pabuçcu¹,

Çağlar²,

Kiseli³

et al. 2016

The Journal of Maternal-Fetal & Neonatal Medicine

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Prognostic Role of Maternal Neutrophil Gelatinase-Associated Lipocalin in Women with Severe Early-Onset Preeclampsia

Cited by 14 publications

References 33 publications

Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Acute Kidney Injury in Severe Preeclamptic Patients Admitted to Intensive Care Unit: Epidemiology and Role of Serum Neutrophil Gelatinase-associated Lipocalcin

Does maternal hydronephrosis have an impact on urinary neutrophil gelatinase-associated lipocalin (uNGAL) levels?

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