Prognostic Role of microRNA-205 in Human Gynecological Cancer: A Meta-Analysis of Fourteen Studies

Wu, Zhixi; Tang, Hong; Xiong, Qian; Liu, Dong; Xia, Tingting; Liang, Huihong; Ye, Qingjian

doi:10.1089/dna.2019.5316

Cited by 9 publications

(5 citation statements)

References 45 publications

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“…For example, an upregulation of miR-486-5p has been detected in both tissues and serum samples from patients with EC [ 17 ]. Similarly, a meta-analysis identified that a high level of miR-205 might lead to poor disease-specific survival in patients with EC [ 18 ]. High expression of miR-21-5p or miR-940 has also been related to shorter overall survival [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study

Yang

Guo

et al. 2021

Bioengineered

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The clinicopathological value of microRNA-141-3p (miR-141-3p) and its prospective target genes in endometrial carcinoma (EC) remains unclear. The present study determined the expression level of miR-141-3p in EC via quantitative real-time PCR (RT-qPCR). RT-qPCR showed a markedly higher expression level of miR-141-3p in EC tissues than in non-EC endometrium tissues (P < 0.0001). The microarray and miRNA-seq data revealed upregulation of miR-141-3p. Integrated analysis based on 675 cases of EC and 63 controls gave a standardized mean difference of 1.737, confirmed the upregulation of miR-141-3p. The Kaplan-Meier survival curve showed that a higher expression of miR-141-3p positively corelated with a poorer prognosis. Combining the predicted targets and downregulated genes in EC, we obtained 271 target genes for miR-141-3p in EC. Two potential targets, PPP1R12A and PPP1R12B, were downregulated at both the mRNA and protein levels. This study indicates that the overexpression of miR-141-3p may play an important part in the carcinogenesis of EC. The overexpression of miR-141-3p may be a risk factor for the prognosis of patients with EC.

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Section: Introductionmentioning

confidence: 99%

Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study

Yang

Guo

et al. 2021

Bioengineered

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“…Because ROS-mediated activation of STAT3 signaling aggravates endothelial dysfunction in diabetes [ 42 ], and because disturbance in redox homeostasis provokes genome-wide changes in transcriptional landscape and chromatin accessibility [ 43 ], we reason that SMARCA5 may function as an important converging point linking oxidative stress, transcriptional reprogramming, and endothelial dysfunction in diabetes. Moreover, miR-205 and miR-151-5p have been shown previously to inhibit SMARCA5 expression and negatively regulates its function in different cell types [ 44 , 45 ]. There is increasing evidence that miRNAs are responsible for fine-tuning the gene expression of important targets in the metabolic syndrome and T2DM [ 46 ], and deregulation of miRNA function (e.g., up-regulation of miR-205 or miR-151-5p) precedes and predicts endothelial dysfunction, thus contributing essentially to pathogenesis or progression of diabetes [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes

Wang¹,

Zhou²,

Shao³

et al. 2023

Diabetes Metab J

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Background: Dysfunction of vascular endothelial cells (ECs) plays a central role in the pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMAR-CA5) is a key regulator of chromatin structure and DNA repair, but its role in ECs remains surprisingly unexplored. The current study was designed to elucidate the regulated expression and function of SMARCA5 in diabetic ECs. Methods: SMARCA5 expression was evaluated in ECs from diabetic mouse and human circulating CD34 + cells using quantitative reverse transcription polymerase chain reaction and Western blot. Effects of SMARCA5 manipulation on ECs function were evaluated using cell migration, in vitro tube formation and in vivo wound healing assays. Interaction among oxidative stress, SMARCA5 and transcriptional reprogramming was elucidated using luciferase reporter assay, electrophoretic mobility shift assay and chromatin immunoprecipitation. Results: Endothelial SMARCA5 expression was significantly decreased in diabetic rodents and humans. Hyperglycemia-suppressed SMARCA5 impaired EC migration and tube formation in vitro, and blunted vasculogenesis in vivo. Contrarily, overexpression of SMARCA5 in situ by a SMARCA5 adenovirus-incorporated hydrogel effectively promoted the rate of wound healing in a dorsal skin punch injury model of diabetic mice. Mechanistically, hyperglycemia-elicited oxidative stress suppressed SMAR-CA5 transactivation in a signal transducer and activator of transcription 3 (STAT3)-dependent manner. Moreover, SMARCA5 maintained transcriptional homeostasis of several pro-angiogenic factors through both direct and indirect chromatin-remodeling mechanisms. In contrast, depletion of SMARCA5 disrupted transcriptional homeostasis to render ECs unresponsive to established angiogenic factors, which ultimately resulted in endothelial dysfunction in diabetes. Conclusion: Suppression of endothelial SMARCA5 contributes to, at least in part, multiple aspects of endothelial dysfunction, which may thereby exacerbate cardiovascular complications in diabetes.

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“…Gynecological malignancies are the leading cause of female mortality in the United States (1). Despite advancements in the identification and treatment of gynecological malignancies, the survival rate has remained constant for decades (2). Gynecological cancers predominately comprise cervical, endometrial and ovarian cancers (3).…”

Section: Introductionmentioning

confidence: 99%

Application of robotic surgery and traditional laparoscopic surgery in lymph node dissection for gynecological cancer: A meta‑analysis

Chen

Wei

et al. 2023

Oncol Lett

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Since the advantages of robotic surgery and laparoscopic surgery in the number of lymph node resections are not well understood, this meta-analysis used evidence-based medicine to assess the difference in the number of lymph nodes retrieved in gynecological cancer between the two surgical methods to guide clinical treatment. In the present meta-analysis, the Pubmed, Embase, Cochrane, China National Knowledge Infrastructure and Wanfang libraries were searched for articles that were published from the time of the database's inception to January 2021, including cohort studies and randomized controlled trials, where the observation group underwent robotic surgery to treat gynecological cancers and the control group underwent laparoscopic surgery to treat gynecological cancers, including cervical and ovarian cancers and endometrial cancers. Duplicate publications, studies with no full text, incomplete information or where the authors were unable to perform data extraction, animal experiments, reviews and systematic reviews were excluded. STATA 15.1 was used to analyze the data. Robotic surgery resulted in a significant increase in the number of lymph nodes retrieved from the pelvis [standard mean difference (SMD)=0.24; 95% CI, 0.04-0.45; P=0.007] and para-aortic (SMD=0.41; 95% CI, 0.13-0.69; P=0.004) regions compared with the number retrieved by laparoscopic surgery. Furthermore, there was no significant difference in operating time between robotic and laparoscopic surgery, despite the use of different instruments (SMD=0.12; 95% CI, -0.35-0.58; P=0.616). The amount of blood lost during robotic surgery was significantly less compared with that lost during laparoscopic surgery [SMD=-0.40; 95% CI, -0.58-(-0.22); P<0.001]. The present study evaluated cancer recurrence and death in further detail, and no statistically significant difference was demonstrated between robotic surgery and laparoscopic surgery in terms of recurrence rate [odds ratio (OR)=0.59; 95% CI, 0.21-1.65; P=0.318] and mortality rate (OR=0.31; 95% CI, 0.08-1.30; P=0.109). The present study demonstrated that robotic surgery was able to retrieve more pelvic and para-aortic lymph nodes than traditional laparoscopic surgery, which was consistent with previous reports. With regards to blood loss, The difference in operation time between the two surgical methods was not statistically significant, whereas the estimated blood loss of robotic surgery was significantly lower than that of traditional laparoscopic surgery. There was no statistically significant difference in the recurrence rate and mortality rate of the two surgical modality.

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Prognostic Role of microRNA-205 in Human Gynecological Cancer: A Meta-Analysis of Fourteen Studies

Cited by 9 publications

References 45 publications

Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study

Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study

Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes

Application of robotic surgery and traditional laparoscopic surgery in lymph node dissection for gynecological cancer: A meta‑analysis

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