Prognostic role of neutrophil to lymphocyte ratio in advanced melanoma treated with anti‐programmed death‐1 therapy

Minowa, Tomoyuki; Kato, Junji; Hida, Tokimasa; Sato, Sayuri; Sawada, Masahide; Uhara, Hisashi

doi:10.1111/1346-8138.14297

Cited by 7 publications

(24 citation statements)

References 4 publications

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“…Subsequently, four studies were eliminated owing to the following reasons: two articles had insufficient data, one was a duplicate study with overlapping patients, and one did not focus on melanoma. Finally, nine studies (15)(16)(17)(18)(19)(20)(21)(22)(23) were included in this meta-analysis. 1) (20).…”

Section: Search Results and The Description Of The Studiesmentioning

confidence: 99%

“…Seven studies were published in English (15, 16, 18-20, 22, 23), and two were in Chinese (17,21). Eight studies with 2,341 patients (15)(16)(17)(18)(19)(20)(21)(22) provided the data for OS, and five studies with 1,892 patients (15,16,20,22,23) presented the prognostic value of the PLR considering PFS. The cutoff values of the PLR ranged from 99 to 206; the median value was 120.…”

Section: Search Results and The Description Of The Studiesmentioning

confidence: 99%

“…The association between the PLR and OS was reported in eight studies including 2,341 patients (15)(16)(17)(18)(19)(20)(21)(22). The HRs and 95% CIs were extracted and combined by using a random-effects model because of significant heterogeneity (I 2 = 97.2%, p < 0.001; Figure 2A; Table 2).…”

Section: The Association Between the Platelet-to-lymphocyte Ratio Andmentioning

confidence: 99%

“…Many studies have confirmed that the PLR is an independent prognostic factor for gastric cancer (10), bladder cancer (11), esophageal cancer (12), breast cancer (13), and non-small-cell lung cancer (14). A number of studies have also explored the prognostic significance of the PLR in patients with melanoma, although the results remain controversial (15)(16)(17)(18)(19)(20)(21)(22)(23). For example, some researchers reported that higher pretreatment PLR was a poor prognostic marker for patients with melanoma (16,17,19); whereas some other investigators found that there was a non-significant association between PLR and survival outcomes in melanoma (18,23).…”

Section: Introductionmentioning

confidence: 99%

“…A number of studies have also explored the prognostic significance of the PLR in patients with melanoma, although the results remain controversial (15)(16)(17)(18)(19)(20)(21)(22)(23). For example, some researchers reported that higher pretreatment PLR was a poor prognostic marker for patients with melanoma (16,17,19); whereas some other investigators found that there was a non-significant association between PLR and survival outcomes in melanoma (18,23). Therefore, we performed a meta-analysis to systematically analyze the prognostic value of the PLR in patients with melanoma by using the currently available clinical evidence.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Melanoma: A Meta-Analysis

Zhang

Gong

2020

Front. Oncol.

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Background: The prognostic role of the platelet-to-lymphocyte ratio (PLR) is controversial in patients with melanoma. Therefore, we performed a meta-analysis to assess the prognostic value of the PLR in patients with melanoma. Methods: PubMed, Web of Science, Embase, Cochrane library, WanFang, and China National Knowledge Infrastructure were searched for eligible studies. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the association between the PLR and overall survival (OS) and progression-free survival (PFS). Results: Nine studies with 2,396 patients were included in this meta-analysis. A high PLR was a predictor of shorter OS (HR = 1.67, 95% CI = 1.18-2.38, p = 0.004), but not PFS (HR = 1.53, 95% CI = 0.96-2.44, p = 0.075) in patients with melanoma. Subgroup analysis revealed that the PLR remained a significant prognostic indicator of both OS and PFS in patients with non-metastatic disease; the PLR cutoff value of <120 had a consistent prognostic value. Conclusions: An increased PLR was associated with poor OS of patients with melanoma. Hence, we suggest that the preoperative PLR could be used to identify high-risk patients and provide information regarding the prognosis of patients with melanoma.

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Section: Search Results and The Description Of The Studiesmentioning

confidence: 99%

Section: Search Results and The Description Of The Studiesmentioning

confidence: 99%

Section: The Association Between the Platelet-to-lymphocyte Ratio Andmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Melanoma: A Meta-Analysis

Zhang

Gong

2020

Front. Oncol.

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Prognostic and clinicopathological significance of the platelet‐to‐lymphocyte ratio in melanoma: A meta‐analysis involving 2099 patients

Han

Feng

Liu

2020

The Kaohsiung J of Med Scie

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To investigate the prognostic role of the platelet‐to‐lymphocyte ratio (PLR) in melanoma through a meta‐analytical method. The literature was searched using the PubMed, Embase, Web of Science, Cochrane Library, and Scopus electronic platforms. Hazard ratios (HRs) for overall survival (OS) and progression‐free survival (PFS) and their corresponding 95% confidence intervals (CIs) were calculated. Begg's test and Egger's test were used to assess potential publication bias. A total of eight retrospective cohort studies involving 2099 patients were included in the meta‐analysis. No significant association between the PLR and OS was found (HR = 1.39; 95% CI = 0.97‐1.99; P = .075). There was also a nonsignificant correlation between the PLR and PFS (HR = 1.49; 95% CI = 0.98‐2.27; P = .065). In addition, there was no significant association between the PLR and sex (odds ratio [OR] = 1.14; 95% CI = 0.23‐5.66; P = .869) or age (OR = 0.81; 95% CI = 0.41‐1.59; P = .539). No significant publication bias was found in this meta‐analysis. The pooled analysis suggests that the PLR may not be a significant prognostic marker in patients with melanoma.

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The Prognostic Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Melanoma Patients Receiving Immunotherapy

Sun

et al. 2021

Journal of Immunotherapy

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Prognostic role of neutrophil to lymphocyte ratio in advanced melanoma treated with anti‐programmed death‐1 therapy

Cited by 7 publications

References 4 publications

Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Melanoma: A Meta-Analysis

Prognostic Value of the Platelet-to-Lymphocyte Ratio in Patients With Melanoma: A Meta-Analysis

Prognostic and clinicopathological significance of the platelet‐to‐lymphocyte ratio in melanoma: A meta‐analysis involving 2099 patients

The Prognostic Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Melanoma Patients Receiving Immunotherapy

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