Prognostic role of pretreatment serum ferritin concentration in lung cancer patients: A meta-analysis

Gao, Yang; Ge, Jin-Tong

doi:10.12998/wjcc.v10.i33.12230

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Zhou et al observed higher levels of serum ferritin and CRP in patients with lung cancer, and regarding the non-small cell lung cancer (NSCLC) subtype, they measured higher values of these parameters in patients with adenocarcinoma compared to those with squamous cell carcinoma [ 38 ]. Additionally, a meta-analysis showed that increased serum ferritin concentration was significantly associated with worse overall survival [ 39 ]. Some studies have shown elevated levels of ferritin in other types of cancer than lung cancer.…”

Section: Discussionmentioning

confidence: 99%

The Association of IFN-γ, TNF-α, and Interleukins in Bronchoalveolar Lavage Fluid with Lung Cancer: A Prospective Analysis

Hogea

Manolescu

Fira-Mlădinescu

et al. 2023

JPM

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Lung cancer is a leading cause of cancer-related mortality worldwide. Identifying novel diagnostic and prognostic biomarkers is essential for improving patient outcomes. This study aimed to investigate the predictive role of cytokines from bronchoalveolar lavage fluid (BALF) in lung cancer diagnosis and prognosis. A prospective study was conducted on 33 patients with suspected lung cancer, divided into inflammatory and non-inflammatory BALF groups. Inflammatory markers in BALF were assessed, and their association with lung cancer risk was analyzed using receiver operating characteristic (ROC) plot analysis, sensitivity and specificity percentages, and regression analysis. Statistically significant differences were observed between the inflammatory and non-inflammatory groups for several inflammatory markers, including IFN-gamma, IL-1b, IL-2, IL-6, IL-10, and IL-12p70. In the follow-up analysis, significant differences persisted for IFN-gamma, IL-1b, IL-2, IL-4, and IL-6. ROC plot analysis revealed that IL-12p70 had the highest area under the curve (AUC) value (0.702), followed by IL-2 (0.682), IL-6 (0.620), IL-4 (0.611), TNF-alpha (0.609), IL-10 (0.604), IL-1b (0.635), and IFN-gamma (0.521). IL-6 showed the highest sensitivity (73%), and IL-1b had the highest specificity (69%). Regression analysis demonstrated that IL-6 (cut-off = 25 pg/mL) and IL-12p70 (cut-off = 30 pg/mL) had the highest odds ratios for lung cancer risk, at 5.09 (95% CI: 2.38–9.24, p < 0.001) and 4.31 (95% CI: 1.85–8.16, p < 0.001), respectively. Cytokines from BALF, particularly IL-6 and IL-12p70, show potential as diagnostic and prognostic biomarkers for lung cancer. Further studies with larger cohorts are warranted to confirm these findings and elucidate the clinical implications of these markers in lung cancer management.

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Section: Discussionmentioning

confidence: 99%

The Association of IFN-γ, TNF-α, and Interleukins in Bronchoalveolar Lavage Fluid with Lung Cancer: A Prospective Analysis

Hogea

Manolescu

Fira-Mlădinescu

et al. 2023

JPM

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“…Moreover, sFT has also been associated with sarcopenia in patients with gastric cancer [92]. Serum ferritin concentration has been described as a reliable prognostic indicator in other oncologic pathologies, such as multiple myeloma [93], lung cancer [94], and Hodgkin lymphoma [95].…”

Section: Role Of Circulating Ferritin In Health and Diseasementioning

confidence: 99%

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Fonseca,

Ramos,

Gomes

et al. 2023

Molecules

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The diagnosis of iron disturbances usually includes the evaluation of serum parameters. Serum iron is assumed to be entirely bound to transferrin, and transferrin saturation—the ratio between the serum iron concentration and serum transferrin—usually reflects iron availability. Additionally, serum ferritin is commonly used as a surrogate of tissue iron levels. Low serum ferritin values are interpreted as a sign of iron deficiency, and high values are the main indicator of pathological iron overload. However, in situations of inflammation, serum ferritin levels may be very high, independently of tissue iron levels. This presents a particularly puzzling challenge for the clinician evaluating the overall iron status of the patient in the presence of an inflammatory condition. The increase in serum ferritin during inflammation is one of the enigmas regarding iron metabolism. Neither the origin, the mechanism of release, nor the effects of serum ferritin are known. The use of serum ferritin as a biomarker of disease has been rising, and it has become increasingly diverse, but whether or not it contributes to controlling the disease or host pathology, and how it would do it, are important, open questions. These will be discussed here, where we spotlight circulating ferritin and revise the recent clinical and preclinical data regarding its role in health and disease.

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Prognostic role of pretreatment serum ferritin concentration in lung cancer patients: A meta-analysis

Cited by 2 publications

References 34 publications

The Association of IFN-γ, TNF-α, and Interleukins in Bronchoalveolar Lavage Fluid with Lung Cancer: A Prospective Analysis

The Association of IFN-γ, TNF-α, and Interleukins in Bronchoalveolar Lavage Fluid with Lung Cancer: A Prospective Analysis

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

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