Prognostic Role of the Pectoralis Musculature in Patients with COVID-19. A Multicenter Study

Surov, Alexey; Kardas, Hakan; Besutti, Giulia; Pellegrini, Massimo; Ottone, Marta; Onur, Mehmet Ruhi; Atak, Fırat; Erdemir, Ahmet Gürkan; Hocaoğlu, Elif; Yıldız, Ömer; İnci, Ercan; Cingöz, Eda; Cingoz, Mehmet; Dursun, Memduh; Korkmaz, İnan; Orhan, Çağrı; Strobel, Alexandra; Wienke, Andreas; Pech, Maciej

doi:10.1016/j.acra.2022.05.003

Cited by 22 publications

(26 citation statements)

References 36 publications

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“… 30 In a multicenter study evaluating 1138 patients, although the MI and MV values were higher in the survivor group, no muscle parameter obtained from CT was associated with negative outcomes related to COVID-19. 20 Similar negative results were found in other studies for both the whole sample and patients aged over 65 years. 31 , 32 There may be many reasons for these discrepancies.…”

Section: Discussionsupporting

confidence: 84%

“…In the literature, there are positive and negative views concerning the use of these parameters in predicting the prognosis of COVID-19. 13 , 18 – 21 Therefore, we considered that it was important to evaluate musculoskeletal parameters in the same population with largely similar etiological risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies included patients that presented to the outpatient clinic or emergency department, or critically ill patients as in our study. 19 , 20 , 32 In the literature, it is reported that the annual rate of skeletal muscle loss is approximately 0.1% to 0.5% per year from the age of 30 years, and this rate increases dramatically after the age of 65 years. 33 In previous research, the mean age of patients varies between 48 and 65 years.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of Diaphragm Diameter, Muscle Volume, and Bone Mineral Density in Critically Ill COVID-19 Patients

Emekli

Can

2023

J Intensive Care Med

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Objective We aimed to analyze the prognostic value of muscle volume (MV), bone mineral density (BMD), and diaphragm diameter (DD) in COVID-19. Method The study included 498 patients admitted to the intensive care unit (ICU) with a positive polymerase chain reaction test for COVID-19 from March 11, 2020, through August 31, 2022. The patients’ laboratory and demographic data of the patients at the time of ICU admission were recorded. MV, DD, and BMD measurements were performed using computed tomography examinations. Muscle index (MI) was calculated as MV/height2. Quartiles were determined for all 4 measurements. Patients in the lowest quartile were recorded as having low MV, MI, DD, and BMD values. The parameters were evaluated for the whole group and compared according to gender and mortality. The multiple regression analysis was performed for the prediction of mortality. Results In the mortality group, the male and female patients had significantly statistically lower values in MV ( P < .001 and P = .002, respectively), MI ( P < .001 and P = .005, respectively), DD ( P < .001 and P < .001, respectively), and BMD ( P = .002 and P < .001, respectively). In the multiple regression analysis, low MI (OR: 2.03, 95% CI: 1.14-3.61, P = .016) and DD (OR: 10.47, 95% CI: 5.59-19.59, P < .001) values remained significant for the prediction of mortality. Conclusion BMD is a risk factor for mortality in patients with severe COVID-19, but cannot be used as an independent predictor. However, MI and DD can be used as independent predictors of mortality even in severe cases.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic Value of Diaphragm Diameter, Muscle Volume, and Bone Mineral Density in Critically Ill COVID-19 Patients

Emekli

Can

2023

J Intensive Care Med

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“…The relationship between mortality and body composition abnormalities was investigated in 36 studies ( 4 , 37 , 40 , 42 , 43 , 46 , 47 , 48 , 50 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 70 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ) ( Figure 3 , Supplementary Table 4 ). Out of 24 of these studies, 12 showed that skeletal muscle mass assessed by either CT ( 43 , 47 , 50 , 56 , 61 , 77 , 78 , 80 , 86 , 88 ) or US ( 42 , 46 ) was negatively associated with in-hospital mortality and 30-day mortality ( 4 , 40 , 42 , 43 , 46 , 47 , 50 , 53 , 54 , 56 , 57 , 58 , 60 , 61 ,…”

Section: Resultsmentioning

confidence: 99%

Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review

Montes‐Ibarra

Orsso

Limon‐Miro

et al. 2023

The American Journal of Clinical Nutrition

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“…For example, a higher pneumonia severity score (PSS), which assesses the severity of lung involvement, as well as a lower pectoralis muscle area (PMA) are significant predictors of prolonged hospital stay, intubation and mortality in adult patients with COVID-19. 19 , 20 In fact, the pectoralis major and minor muscles are associated with breathing, assisting inspiration. 21 In addition, PMA has been used as an indicator of global muscle-wasting and the severity of various diseases.…”

Section: Introductionmentioning

confidence: 99%

30 s sit-to-stand power is positively associated with chest muscle thickness in COVID-19 survivors

et al. 2022

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Introduction After hospitalization, early detection of musculoskeletal sequelae might help healthcare professionals to improve and individualize treatment, accelerating recovery after COVID-19. The objective was to determine the association between the 30s sit-to-stand muscle power (30s-STS) and cross-sectional area of the chest muscles (pectoralis) in COVID-19 survivors. Method This cross-sectional study collected routine data from COVID-19 survivors one month after hospitalization: 1) a chest computed tomography (CT) scan and 2) a functional capacity test (30s-STS). The pectoralis muscle area (PMA) was measured from axial CT images. For each gender, patients were categorized into tertiles based on PMA. The 30s-STS was performed to determine the leg extension power. The allometric and relative STS power were calculated as absolute 30s-STS power normalized to height squared and body mass. The two-way ANOVA was used to compare the gender-stratified tertiles of 30s-STS power variants. Results Fifty-eight COVID-19 survivors were included (mean age 61.2 ± 12.9 years, 30/28 (51.7%/48.3%) men/women). The two-way ANOVA showed significant differences between the PMA tertiles in absolute STS power ( p = .002) and allometric STS power ( p = .001). There were no significant gender x PMA tertile interactions (all variables p > .05). The high tertile of PMA showed a higher allometric STS power compared to the low and middle tertile, p = .002 and p = .004, respectively. Absolute STS power and allometric STS power had a moderate correlation with the PMA, r = 0.519 ( p < .001) and r = 0.458 ( p < .001) respectively. Conclusion The 30s-STS power is associated with pectoralis muscle thickness in both male and female COVID-19 survivors. Thus, this test may indicate global muscle-wasting and may be used as a screening tool for lower extremity functional capacity in the early stages of rehabilitation planning in COVID-19 survivors.

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Prognostic Role of the Pectoralis Musculature in Patients with COVID-19. A Multicenter Study

Cited by 22 publications

References 36 publications

Prognostic Value of Diaphragm Diameter, Muscle Volume, and Bone Mineral Density in Critically Ill COVID-19 Patients

Prognostic Value of Diaphragm Diameter, Muscle Volume, and Bone Mineral Density in Critically Ill COVID-19 Patients

Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review

30 s sit-to-stand power is positively associated with chest muscle thickness in COVID-19 survivors

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