Prognostic scoring models in parotid gland carcinoma

Abstract

Background The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma. Methods All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index. Results The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence‐free survival. The prognostic model that agreed best with actual outcomes had a C‐index of 0.76. Conclusion Prognostic scoring models may improve individualized follow‐up strategies after curatively intended treatment for patients with parotid gland carcinoma.

Long‐Term Facial Nerve Outcome in Primary Parotid Cancer Surgery: A Population‐Based Analysis

“…The mean incidence of parotid cancer in Thuringia was 0.94/100.000/year. This lies in the range reported for other countries like Denmark, Finland, the Netherlands, and the U.S.A. 17,[37][38][39] The mean incidence of patients with parotic cancer and preoperative and/or permanent postoperative facial nerve dysfunction was 0.27/100.000/ year. This means for Germany, a country with 83 million habitants, that about 219 new cases per year of treated parotid cancer with permanent facial nerve dysfunction have to be expected.…”

“…Population‐based data on parotid cancer are sparse. Based on cancer registry data, there are a few actual studies all focusing on oncological outcome 14–17 . The present study is, to our knowledge, the first to present data on facial function outcome in a population‐based setting.…”

“…Based on cancer registry data, there are a few actual studies all focusing on oncological outcome. [14][15][16][17] The present study is, to our knowledge, the first to present data on facial function outcome in a population-based setting. This is important because long-term quality of life in patients with parotid cancer is mainly influenced by facial nerve function.…”

“…2,3,5 Clinical cancer registries allow to explore the oncological outcome from a population-based perspective but do not allow to evaluate the long-term facial nerve outcome. [14][15][16][17] Therefore, the present retrospective observational cohort study combined a population-based analysis on cancer registry data from all Thuringian patients treated for primary parotid cancer between 1996 and 2019 with a hospital-based approach. We went back to the charts of all registered patients to evaluate in addition facial nerve management and facial function outcome.…”

“…Most knowledge results from larger monocentric series and retrospective studies and therefore has methodological limitations 2,3,5 . Clinical cancer registries allow to explore the oncological outcome from a population‐based perspective but do not allow to evaluate the long‐term facial nerve outcome 14–17 …”