Prognostic significance of age in patients with acute ischaemic stroke treated with intravenous thrombolysis

Wnuk, Marcin; Drabik, Leszek; Derbisz, Justyna; Słowik, Agnieszka

doi:10.5603/pjnns.a2022.0010

Cited by 3 publications

(2 citation statements)

References 30 publications

(99 reference statements)

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“…Patients with stroke in old age have shown a higher risk of functional dependence and poorer functional recovery. This would affect their eating ability, in addition to the natural changes of aging [25,26]. Our study also revealed that age was a significantly associated factor for malnutrition in both acute and subacute stroke phases.…”

Section: Discussionsupporting

confidence: 51%

Malnutrition and Associated Factors in Acute and Subacute Stroke Patients with Dysphagia

Yoon,

Baek,

Jang

et al. 2023

Nutrients

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Most patients with stroke suffer from complications and these include dysphagia. Dysphagia can cause malnutrition, and malnutrition affects prognosis and recovery. However, there is a lack of accurate studies on the nutritional status of stroke patients with dysphagia and its associated factors in different phases of stroke. This study retrospectively investigated 620 stroke patients who underwent a videofluoroscopic swallowing study (VFSS) due to dysphagia, from March 2018 to February 2021. The study aimed to evaluate the nutritional state and associated factors of malnutrition in acute and subacute stroke patients with dysphagia. Serum albumin and percentage of current weight to ideal weight were used to determine nutritional status. Malnutrition was observed in 58.9 and 78.9% of acute and subacute stroke patients. Exact logistic regression analysis revealed that old age and high penetration–aspiration scale score were significantly associated factors for malnutrition in patients with acute stroke. Old age, stroke history, bilateral hemiplegia, high modified Rankin score, low Korean Mini-Mental State Examination, pneumonia, and high functional dysphagia score were significantly associated factors for malnutrition in patients with subacute stroke. Patients with these associated factors in each phase of stroke require active nutritional assessment and care to decrease the risk of malnutrition.

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Section: Discussionsupporting

confidence: 51%

Malnutrition and Associated Factors in Acute and Subacute Stroke Patients with Dysphagia

Yoon,

Baek,

Jang

et al. 2023

Nutrients

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“…The inclusion criteria for the study were admission within 12 h after AIS onset, a previous Barthel score ≥ 85 (as signs of disability before stroke are independent risk factors for worse prognosis, especially in elderly AIS patients treated with intravenous thrombolysis [20]), and the absence of stupor or coma.…”

Section: Data Collectionmentioning

confidence: 99%

Association between nocturnal oxygen desaturation and ischaemic stroke outcomes

Wojtasz¹,

Tomski

Kaźmierski

2022

Neurol Neurochir Pol.

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Clinical rationale for the study. This study aimed to assess the association between nocturnal hypoxemia and early acute ischaemic stroke (AIS) outcomes in patients without oxygen supplementation.Material and methods. One hundred and six AIS patients consecutively admitted to the stroke unit were included in this study. Baseline demographic and medical data and arterial blood saturation (SpO 2 ) measurements during night-sleep (from 10pm to 6am) were examined for their association with stroke outcomes, including the National Institutes of Health Stroke Scale (NIHSS) score on the 7th day or differences between the NIHSS score on the 1st day and the 7th day after stroke onset.Measurements of SpO 2 were made using a pulse oximeter of the Spacelabs Medical Inc. (USA) monitoring system, and the number of apnoea episodes and their duration were recorded by ECG Holter with respiration monitoring (CardioMem®, Getamed, GE).Results. The study showed that age (Spearman's r = 0.207, p = 0.033) and parameters attributable to anaemia (RBC r = -0.205, p = 0.035, Hb r = -0.225, p = 0.02 and HCT r = -0.196, p = 0.044), atrial fibrillation and ischaemic changes in both brain hemispheres (p = 0.023 and 0.01, respectively) were correlated with the study outcomes.In terms of saturation parameters, we demonstrated that the 'total desaturation burden' (i.e. [100% minus actual measured SpO 2 %] x apnoea duration) and multiple apnoeas of longer than 20 seconds were correlated with worse functional outcomes. Measures of shorter desaturation episodes (i.e. SpO 2 oxygen desaturation index (ODI) at 3% and 4%, and time-weighted desaturations below the determined thresholds (SpO 2 from 95% to 85%) demonstrated non-significant associations with the study outcomes. Conclusions and clinical implications.This study demonstrated that long-lasting desaturation episodes during the night, depicted by the 'total desaturation burden' , were correlated with worse functional outcomes in AIS, while measures of shorter desaturation episodes were not correlated. In future clinical trials, indications for oxygen supplementation should include the methodology of personalised medicine and introduce individual approaches based on specially formulated, novel multifactorial algorithms.

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ASTRAL scale for predicting prognosis following intravenous thrombolysis with anterior versus posterior circulation acute ischemic stroke

Fan,

Shi,

et al. 2024

J Thromb Thrombolysis

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Prognostic significance of age in patients with acute ischaemic stroke treated with intravenous thrombolysis

Cited by 3 publications

References 30 publications

Malnutrition and Associated Factors in Acute and Subacute Stroke Patients with Dysphagia

Malnutrition and Associated Factors in Acute and Subacute Stroke Patients with Dysphagia

Association between nocturnal oxygen desaturation and ischaemic stroke outcomes

ASTRAL scale for predicting prognosis following intravenous thrombolysis with anterior versus posterior circulation acute ischemic stroke

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