Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Rao, Roopa S; K, Lizbeth Raju; Augustine, Dominic; Patil, Shankargouda

doi:10.1177/1073274820904959

Cited by 16 publications

(21 citation statements)

References 68 publications

(107 reference statements)

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“…A possible reason for the same seems to be that the prognosis of HNSCC is not entirely changed by the mRNA expression of only a single gene, because the cancer is caused by the accumulation of multiple mutations in various pathways. However, these four genes have shown clinically significant association with the expression of corresponding CSC biomarker proteins in HNSCC over the past 10 years [5,8,[22][23][24][25][26][27][28]. Thus, we analyzed and confirmed the actual association between mRNA expression of these genes and prognosis in TCGA HNSCC cohort, by referring to these ROC curves.…”

Section: Discussionmentioning

confidence: 83%

“…ALDH1 appears to have protective properties against HNSCC [ 22 ]. In another study, the positive expression of ALDH1 showed significant correlation with lymph node metastasis and poor prognosis [ 25 ]. The positivity of ALDH1 was also found to be correlated with the number of cells undergoing epithelial-mesenchymal transition and metastasis in early stage oral squamous cell carcinoma (OSCC) [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…BMI-1 is important for the self-renewal ability of stem cells and is related to epithelial-mesenchymal transition [ 39 ]. Rao et al found a significant positive correlation between ALDH1 and BMI-1 expression in OSCC tissue samples, although the underlying pathways have not yet been elucidated [ 25 ]. High expression of BMI-1 was associated with poor prognosis in advanced-stage HNSCC treated with primary chemoradiotherapy [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among the 28 CSC genes encoding CSC biomarker proteins that have been validated in HNSCC [10], we selected seven CSC genes that satisfied the following criteria, CD44, MET, ALDH1A1, BMI1, PROM1, SOX2, and POU5F1 from a literature search: (a) showing clinical significance associated with the expression of corresponding CSC biomarker proteins in HNSCC and (b) studied more than twice over the past 10 years [5,8,9,[22][23][24][25][26][27][28][29][30]. In TCGA cohort, high expression of four CSC genes (CD44, MET, ALDH1A1, and BMI1) was significantly associated with patient prognosis (p = 0.0069, 0.0051, 0.028, and 0.021, respectively; Fig.…”

Section: Development Of Csc Gene Expression-associated Signatures In ...mentioning

confidence: 99%

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Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

et al. 2022

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Background Various cancer stem cell (CSC) biomarkers and the genes encoding them in head and neck squamous cell carcinoma (HNSCC) have been identified and evaluated. However, the validity of these factors in the prognosis of HNSCC has been questioned and remains unclear. In this study, we examined the clinical significance of CSC biomarker genes in HNSCC, using five publicly available HNSCC cohorts. Methods To predict the prognosis of patients with HNSCC, we developed and validated the expression signatures of CSC biomarker genes whose mRNA expression levels correlated with at least one of the four CSC genes (CD44, MET, ALDH1A1, and BMI1). Results Patients in The Cancer Genome Atlas (TCGA) HNSCC cohort were classified into CSC gene expression-associated high-risk (CSC-HR; n = 285) and CSC gene expression-associated low-risk (CSC-LR; n = 281) subgroups. The 5-year overall survival and recurrence-free survival rates were significantly lower in the CSC-HR subgroup than in the CSC-LR subgroup (p = 0.04 and 0.02, respectively). The clinical significance of the CSC gene expression signature was validated using four independent cohorts. Analysis using Cox proportional hazards models showed that the CSC gene expression signature was an independent prognostic factor of non-oropharyngeal HNSCC which mostly indicates HPV (–) status. Furthermore, the CSC gene expression signature was associated with the prognosis of HNSCC patients who received radiotherapy. Conclusion The CSC gene expression signature is associated with the prognosis of HNSCC and may help in personalized treatments for patients with HNSCC, especially in cases with HPV (–) status who were classified in more detail.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Development Of Csc Gene Expression-associated Signatures In ...mentioning

confidence: 99%

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Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

et al. 2022

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“…Studies have shown that in HNCs, ALDH1 is mainly regulated by retinoic acid compounds and other oncogenic pathways such as MUC1-C/ERK and WNT/β-catenin ( 191 ), but also by the AKT signaling pathway ( 192 , 193 ). ALDH1A1 increases TUBB3 expression, which down-regulates PTEN and promotes cell proliferation, migration, and invasion ( 194 ).…”

Section: Aldh1 and Various Solid Tumorsmentioning

confidence: 99%

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Wei

Chen

et al. 2022

Front. Oncol.

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Solid tumors can be divided into benign solid tumors and solid malignant tumors in the academic community, among which malignant solid tumors are called cancers. Cancer is the second leading cause of death in the world, and the global incidence of cancer is increasing yearly New cancer patients in China are always the first. After the concept of stem cells was introduced in the tumor community, the CSC markers represented by ALDH1 have been widely studied due to their strong CSC cell characteristics and potential to be the driving force of tumor metastasis. In the research results in the past five years, it has been found that ALDH1 is highly expressed in various solid cancers such as breast cancer, lung cancer, colorectal cancer, liver cancer, gastric cancer, cervical cancer, esophageal cancer, ovarian cancer, head,and neck cancer. ALDH1 can activate and transform various pathways (such as the USP28/MYC signaling pathway, ALDH1A1/HIF-1α/VEGF axis, wnt/β-catenin signaling pathway), as well as change the intracellular pH value to promote formation and maintenance, resulting in drug resistance in tumors. By targeting and inhibiting ALDH1 in tumor stem cells, it can enhance the sensitivity of drugs and inhibit the proliferation, differentiation, and metastasis of solid tumor stem cells to some extent. This review discusses the relationship and pathway of ALDH1 with various solid tumors. It proposes that ALDH1 may serve as a diagnosis and therapeutic target for CSC, providing new insights and new strategies for reliable tumor treatment.

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Biomarkers in Oral Submucous Fibrosis

Ranganathan

Kavitha

2023

Textbooks in Contemporary Dentistry

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Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Cited by 16 publications

References 68 publications

Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

Association between cancer stem cell gene expression signatures and prognosis in head and neck squamous cell carcinoma

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Biomarkers in Oral Submucous Fibrosis

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