Prognostic significance of annexin II expression in non-small cell lung cancer

Luo, Chonglin; Liu, Q.-Q.; Zhang, P.-F.; Li, M.-Y.; Chen, Z.-C.; Liu, Y.-F.

doi:10.1007/s12094-013-1028-y

Cited by 16 publications

(22 citation statements)

References 30 publications

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“…Increased ANXA2 is correlated with poor prognosis of HCC patients. Previous research has shown that ANXA2 over-expression is correlated with poor prognosis of human gastric carcinoma [39], conventional renal cell carcinoma [40], nonsmall cell lung cancer [11,41], esophageal squamous cell carcinoma [42], urothelial carcinoma [43], multiple myeloma [44], and colorectal cancer [12] and predicts rapid recurrence after surgery of endometrial cancer [45] and in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy [46]. ANXA2 down-regulation is associated with recurrence and poor prognosis of prostate cancer [47] and oral squamous cell carcinoma [48].…”

Section: Discussionmentioning

confidence: 99%

“…ANXA2 staining score was the product of the intensity and percentage scores. The cutoff point for a statistically significant ANXA2 expression score in terms of survival was set using the X-tile software program and defined as follows: negative (−): (0-4), weakly positive (+): (4-6), moderately positive (++): (6-9), and strongly positive (9)(10)(11)(12). The staining in HCC and benign liver diseases tissues was scored independently by the two individuals who were blinded to each other's findings and the clinical characteristics of these sections (left panel, ×40, bar 500 μm; right panel, ×400, bar 50 μm) (χ 2 =46.305, P<0.001), single tumor node (χ 2 =7.707, P= 0.005), and early TNM stage (χ 2 =44.188, P<0.001), without intrahepatic metastasis (χ 2 =8.534, P=0.003) and portal vein tumor thrombus (χ 2 =19.988, P<0.001) had a significantly better prognosis (Fig.…”

Section: Univariate and Multivariate Analyses Of Prognostic Variablesmentioning

confidence: 99%

“…One of these prognostic factors recently described is annexin A2 (ANXA2), a calcium-dependent phospholipidbinding member of the annexin family [11,12]. ANXA2 is first identified as a phosphorylation substrate of v-Src [13] and involved in diverse biological functions including vesicle trafficking, differentiation, apoptosis, calcium-dependent signaling transduction, actin rearrangement, cell motility, and growth regulation [14,15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Up-regulation of annexin A2 expression predicates advanced clinicopathological features and poor prognosis in hepatocellular carcinoma

Zhang

Yao

et al. 2015

Tumor Biol.

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Hepatic annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical symptoms and plays a key role in development, metastasis, and drug resistance of lethal hepatocellular carcinoma (HCC). However, the prognostic significance of ANXA2 for HCC has not been elucidated up to now. In this study, ANXA2 was frequently found to be up-regulated in HCC tissues compared with benign liver disease (BLD) tissues, which was consistent with the results in serum samples and tissue specimens of patients with HCC. Furthermore, ANXA2 expression was significantly correlated with differentiated degree, intrahepatic metastasis, portal vein thrombus, and tumor node metastasis (TNM) staging. More importantly, increased ANXA2 level was first confirmed to be closely associated with shortened overall survival of HCC (χ (2) = 12.872, P = 0.005) and identified as an independent prognostic factor (hazard ratio 1.338, 95 % confidence interval (CI) 1.013 ~ 1.766, P = 0.040), suggesting that ANXA2 up-regulation might represent an acquired metastasis phenotype of HCC, help to screen out high-risk population for HCC, or more effectively treat a subset of postsurgical HCC patients positive for ANXA2.

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Section: Discussionmentioning

confidence: 99%

Section: Univariate and Multivariate Analyses Of Prognostic Variablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Up-regulation of annexin A2 expression predicates advanced clinicopathological features and poor prognosis in hepatocellular carcinoma

Zhang

Yao

et al. 2015

Tumor Biol.

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“…Accumulated evidence supported the pivotal role of Anxa2 in carcinogenesis and cancer progression [3,27,48,60]. Anxa2 overexpression has been observed in many human malignancy tumors, including breast cancer [41], colorectal cancer [8,10], pancreatic cancer [11,45], renal cell carcinoma [32], hepatocellular carcinoma [29,53], glioma [13], gastric cancer [9], and lung cancer [28]. The increased expression levels of Anxa2 in cancer tissues are associated with rapid recurrence [21,45], metastasis [32,52], poor response to chemotherapy [6,20], and poor prognosis [32,45].…”

Section: Introductionmentioning

confidence: 99%

RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway

Zhang

Wang

Yuan

et al. 2015

Breast Cancer Res Treat

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Although the upregulated expression of Anxa2 has been implicated in carcinogenesis, cancer progression, and poor prognosis of cancer patients, the detailed molecular mechanisms involved in these processes remain unclear. In this study, we investigated the effect of Anxa2 downregulation with small interference RNA on breast cancer proliferation. To explore molecular mechanisms underlying Anxa2-mediated cancer cell proliferation. We analyzed cell cycle distribution and signaling pathways using semi-quantitative real-time PCR and Western blotting. Anxa2 depletion in breast cancer cells significantly inhibited cell proliferation by decelerating cell cycle progression. The retarded G1-to-S phase transition in Anxa2-silenced cells was attributed to the decreased levels of cyclin D1, which is a crucial promoting factor for cell proliferation because it regulates G1-to-S phase transition during cell cycle progression. We provided evidence that Anxa2 regulates epidermal growth factor-induced phosphorylation of STAT3. The reduced expression of phosphorylated STAT3 is the main factor responsible for decreased cyclin D1 levels in Anxa2-silenced breast cancer cells. Our results revealed the direct relationship between Anxa2 and activation of STAT3, a key transcription factor that plays a pivotal role in regulating breast cancer proliferation and survival. This study provides novel insights into the functions of Anxa2 as a critical molecule in cellular signal transduction and significantly improves our understanding of the mechanism through which Anxa2 regulates cell cycle and cancer cell proliferation.

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“…Analogously, the elevated expression of annexin A2 was also detected in lymph node metastatic tissues of lung cancers. 12 In addition, annexin A2 also participates in vascular endothelial growth factor (VEGF)-mediated neovascularization. 13 It has been reported that several immunosuppressive cytokines, including VEGF are detected in the tumor microenvironment.…”

mentioning

confidence: 99%

Modulation of Vascular Endothelial Growth Factor and Annexin A2 in Response to 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone -Induced Inflammation via Swimming Training

Barzegari

Mirdar

Ranayi

2018

IJAAI

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The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; nicotine derived nitrosamine ketone) is one of the strongest carcinogens in tobacco which is involved in induction of lung cancer by changing the stimulation of vascular endothelial growth factor (VEGF) and annexin A2 expression. The aim of this study was to investigate the changes in resting levels of annexin A2 and VEGF in lung tissues of rats exposed NNK after 12 weeks of aerobic submaximal swimming training. For this purpose, 46 Wistar rats were randomly divided into five groups consist of training, training + NNK, NNK, saline and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12/5 mg per kg body weight and the training groups performed submaximal swimming training for 12 weeks. The levels of VEGF and annexin A2 in lung tissue were measured respectively by ELISA and immunohistochemistry. To analyze the data; ANOVA and Tukey's test were used at a significance level of p<0.05. Findings indicated that 12 weeks submaximal swimming training decreased the levels of VEGF and annexin A2 in lung tissue significantly when compared to NNK group (p<0.001). There was no significant correlation between VEGF and annexin A2 levels in all study groups (p≥0.05). Generally, it could be confirmed that regular submaximal aerobic training plays an important role in inhibition of the effects of lung inflammation induced by NNK via decreased levels of VEGF and annexin A2.

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Prognostic significance of annexin II expression in non-small cell lung cancer

Abstract: Annexin II was identified as a common prognostic factor in both LSC and AdC.

Cited by 16 publications

References 30 publications

Up-regulation of annexin A2 expression predicates advanced clinicopathological features and poor prognosis in hepatocellular carcinoma

Up-regulation of annexin A2 expression predicates advanced clinicopathological features and poor prognosis in hepatocellular carcinoma

RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway

Modulation of Vascular Endothelial Growth Factor and Annexin A2 in Response to 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone -Induced Inflammation via Swimming Training

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