2013
DOI: 10.4274/tjh.2011.0034
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Prognostic Significance of Bcl-2 and p53 Protein Expressions and Ki67 Proliferative Index in Diffuse Large B-cell Lymphoma

Abstract: Objective: Diffuse large B-cell lymphoma (DLBCL) is a high-grade neoplasm that has heterogeneous properties in clinical, morphological, and immunophenotypic aspects. In the present study the effects of p53, Bcl-2, and Ki67 on prognosis and their relationships with clinical parameters were examined. 
 Materials and Methods: Thirty-five patients who had been diagnosed with nodally located DLBCL at İzmir Atatürk Training and Research Hospital between January 1999 and June 2006 were included in the study. The Ann … Show more

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Cited by 9 publications
(12 citation statements)
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“…The clinical characteristics of the previous reports are summarised in Table I. Morphologically, tumour necroses were identified in two patients in the Dadmanesh series as well as in five more cases [5,10,15,19,24]. A lobular variant of LELC-B has been reported by some authors [3,4,7,9] associated with LCIS [3,4,7], pagetoid spread [4], or with atypical lobular hyperplasia [9].…”
Section: Discussionmentioning
confidence: 97%
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“…The clinical characteristics of the previous reports are summarised in Table I. Morphologically, tumour necroses were identified in two patients in the Dadmanesh series as well as in five more cases [5,10,15,19,24]. A lobular variant of LELC-B has been reported by some authors [3,4,7,9] associated with LCIS [3,4,7], pagetoid spread [4], or with atypical lobular hyperplasia [9].…”
Section: Discussionmentioning
confidence: 97%
“…Lymphoepithelioma-like carcinoma (LELC) is a poorly differentiated carcinoma occurring outside the nasopharynx, which displays identical histological features to its nasopharyngeal counterpart. It has been reported in several anatomic sites including breast [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25], colon [26], esophagus [27], kidney [28], lacrimal gland [29,30], larynx [31], hepatobiliary system [32,33], lungs [34], major and minor salivary glands [35,36,37,38], orbital adnexa [39], prostate [28], skin [40], stomach [41], thymus [42], thyroid [43], trachea [44], ureter [45], urinary bladder [46], uterine cervix [47], vagina [48], and vulva…”
Section: Introductionmentioning
confidence: 99%
“…[15][16] Although survival can be estimated based on clinical parameters (age, LDH levels in serum, extranodal site involvement, disease stage, and immunophenotype B), as well as molecular abnormalities (p53, BCL-2, BCL6, MUM.1 and Ki67), controversy exists regarding their utility as prognostic and survival markers. 17 As a result, it is of paramount importance to find new markers that could be incorporated to determine the prognosis of this disease.…”
Section: Discussionmentioning
confidence: 99%
“…The mRNA expression levels of the NY-ESO-1 (Hs00265824_m1) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH; Hs00985689) genes were measured using the TaqMan® gene expression assay (Applied Biosystems, Foster City, CA, USA). 19 The GAPDH gene was used as an endogenous control, and each sample was analyzed in triplicate. The relative gene expression levels were calculated by the 2 -ΔΔCt method using Testicular tissue as calibrator.…”
Section: Real-time Polymerase Chain Reaction (Qrt-pcr) Analysismentioning
confidence: 99%
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